Protein Alignment Tie and kitb

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001137390.2
• Gene: kitb / 497629
• ZFINID: ZDB-GENE-050916-2
• Length: 957
• Species: Danio rerio
• Alignment Length: 921
• Identity: 197/921 - (21%)
• Similarity: 314/921 - (34%)
• Gaps: 300/921 - (32%)

  Fly   511 LPTDESTTTTSTTTTTEKPSTTTSTSTTT---------TTPVPSTSKRTTTN-----------AP 555
            |..||::......|.|:.....|..:|.|         ...:.|...|...|           .|
Zfish    69 LKDDEASVILLNITETQHMGNYTCENTETEEKSSIYIYVKDLGSAFVRRMVNDLQVRKGEEITLP 133

  Fly   556 LSTTNTPT------TTTSSTTPSTTT--TSSTSTTVIPTTTKA-------------NSIIEKDKE 599
            ...|:...      |...|..|:..|  |.......|...:||             ..:..::..
Zfish   134 CLVTDPAVSHLSLQTCNGSALPAALTFITHPQGGITIRNVSKAFEGCYFCAGQLDQKPVKSREYN 198

  Fly   600 LIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVH 664
            |:..|.|.....|::....|:|:..:.......:........|...:.|.  ..|.|.|.:|.:.
Zfish   199 LVVRLAPESVPAISLSRNENVILIQDQEFKLSCSAVNINHDFHLRWTIPS--EATALESHKSNIQ 261

  Fly   665 P--RPTSTSTT---------------TSTTTTAPPAVTAPSNEVY----IGI------------- 695
            |  |....|.|               .:.......::.|.:.|||    |.:
Zfish   262 PGSREYQRSITLWIQSVKINDTGSYRCNARNEKGVSMAAVNLEVYERGFINLTEGENRVVEVREG 326

  Fly   696 ------VESSSSASPADISSTVIANERDL-----------NMEMRRMNLVTLVLV---AVGVIPL 740
                  ||.:|...|.|:..|.  |.::|           |.:.|.::.:.||.|   ..|:...
Zfish   327 ESLTLSVEITSYPKPNDVYWTY--NNQELQNTSEHVITLHNQQYRYISELRLVRVHGSEGGIYTF 389

  Fly   741 AAIILY--LVRNFVIRRRAKQSEVFDVCITDQQPIS----------PVKKVDSKY---------- 783
            :|...|  :.::|.:....|     .|.::.:.|:.          ||.|:...|
Zfish   390 SANHKYESVNQSFTVHVICK-----PVIVSQEGPVDGQVRCVASGYPVPKISWYYCEPPHTRCSH 449

  Fly   784 -----QVDDD------------EDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHN 831
                 |.|::            ..||:.:.:.........:...:.|..||..:...|:|...|.
Zfish   450 LLNATQADEEFAVITVSGSEFGRSEVESRLNISKGKFHTLECVASAQGEQAYTLFSISERTVPHK 514

  Fly   832 RY------------------------------------------GNN---DDKTSLASE-FHDFE 850
            .:                                          |||   .|.|.|..: ..:|.
Zfish   515 LFTPLLSGVVSTSVLLSFILVVLLYKYMQKPKYEIHWKVIDSFDGNNYTYIDPTQLPYDPKWEFP 579

  Fly   851 RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQVSLKDEANIMRKLGS 912
            |..:|...:||.|.||:|..|.|..|......| .||||.::.   .:.:.:|..|..::..:|:
Zfish   580 RERLRFGKILGSGAFGKVVAATAYGLCSADTVT-TVAVKMLKPSAHSTEKEALMSELKVLSYIGN 643

  Fly   913 HQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA-----------TNILPASVPG----- 961
            |.|:|.|||||....|.::|.||...|.||:.||..|.|           .|:|..:.|.
Zfish   644 HINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDAFFSSKTGDGYYKNLLSQTQPSIEGTD 708

  Fly   962 -----GRSLAPLSPRT---------------LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDH 1006
                 .||....|.:|               |..|:..:|.||:::..:..:|||||||||||..
Zfish   709 NGYMPMRSYQKRSNQTEWCDDKDDLSLDTEDLLSFSYQVAKGMDFLTSKNCIHRDLAARNVLLTQ 773

  Fly  1007 NGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGH 1071
            ..:.||||||::.|:..:          :|.::|.||.
Zfish   774 GRVAKICDFGLARDITRD----------SNYVLRGNAR--------------------------- 801

  Fly  1072 CSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYS 1136
                                    ||::||:||||...::|.|:|:|::||:||||.:||:|||.
Zfish   802 ------------------------LPVKWMSPESLFACVYTFESDVWSYGILLWEIFSLGNTPYP 842

  Fly  1137 QL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQ--SRLEITRSLHKWVDD 1198
            .: .|....:.:..|.|...|:.:..|.|.:|..||..:|..||.|.:  .|.|:..|
Zfish   843 GIPVGSTFYKMIQDGYRMSEPEFAPSEIYEVMRWCWSADPLKRPPFKKLVERTELLLS------- 900

  Fly  1199 DSAASDYMDVS 1209
            ::...||:::|
Zfish   901 ETTKHDYLNLS 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	107/368 (29%)
kitb	NP_001137390.2	None