DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and NTRK3

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:XP_016877743.1 Gene:NTRK3 / 4916 HGNCID:8033 Length:850 Species:Homo sapiens


Alignment Length:609 Identity:158/609 - (25%)
Similarity:243/609 - (39%) Gaps:162/609 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   639 QPSHTTDSSPKILRTTVLTSIRSTVH------PRPTSTST---TTSTTTTAPPAVTAPSNEVYIG 694
            :|:|..:.:..::....|.:...|::      |.|.||..   ....:.|.|..||....|...|
Human   367 KPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFG 431

  Fly   695 IVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQ 759
                                                |.:|||:...|.::|.::  ||:..:..:
Human   432 ------------------------------------VSIAVGLAAFACVLLVVL--FVMINKYGR 458

  Fly   760 SEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQAS 824
            ...|.:    :.|::         .:..:||.....||.:              |....|.|..:
Human   459 RSKFGM----KGPVA---------VISGEEDSASPLHHIN--------------HGITTPSSLDA 496

  Fly   825 QRDA--------------NHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADD 875
            ..|.              .:.|.|:|..|..  :.....:|.:|.||..||||.||:|:.||..:
Human   497 GPDTVVIGMTRIPVIENPQYFRQGHNCHKPD--TYVQHIKRRDIVLKRELGEGAFGKVFLAECYN 559

  Fly   876 LSGHFGATR---IVAVKTIR--ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEY 935
            ||    .|:   :||||.::  ..:|:...:.||.::..| .|:::|...|.|.:.:|.:::.||
Human   560 LS----PTKDKMLVAVKALKDPTLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619

  Fly   936 AMRGRLLSLLRAARSATNIL----PASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRD 996
            ...|.|...|||......||    |....|...|:     .:...|..||.||.|:|.:..||||
Human   620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLS-----QMLHIASQIASGMVYLASQHFVHRD 679

  Fly   997 LAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQH 1061
            ||.||.|:..|.:.||.|||||.|:                                |...::: 
Human   680 LATRNCLVGANLLVKIGDFGMSRDV--------------------------------YSTDYYR- 711

  Fly  1062 TFGQGQGQGHCSKDQPHG-----EKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFG 1121
                   :|.|.|. |..     ::.:.....|:|....||||||.|||:.|..||||:|:|:||
Human   712 -------EGPCQKG-PFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFG 768

  Fly  1122 IVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRL 1186
            ::||||.|.|..|:.||:..|||..:.||...:.|:....|.|::|..||.:||..|.:..    
Human   769 VILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIK---- 829

  Fly  1187 EITRSLHKWVDDDSAASDYMDVSG 1210
            ||.:.||..   ..|...|:|:.|
Human   830 EIYKILHAL---GKATPIYLDILG 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 113/342 (33%)
NTRK3XP_016877743.1 LRR_8 103..160 CDD:404697
leucine-rich repeat 105..128 CDD:275378
leucine-rich repeat 129..151 CDD:275378
leucine-rich repeat 152..164 CDD:275378
LRRCT_2 163..208 CDD:465313
ig 214..299 CDD:395002
Ig strand B 227..231 CDD:409568
Ig strand C 240..244 CDD:409568
Ig strand E 266..270 CDD:409568
Ig strand F 281..286 CDD:409568
Ig strand G 294..297 CDD:409568
IgI_TrKABC_d5 304..396 CDD:409360 4/28 (14%)
Ig strand A 305..311 CDD:409360
Ig strand A' 313..316 CDD:409360
Ig strand B 319..327 CDD:409360
Ig strand C 330..337 CDD:409360
Ig strand C' 340..343 CDD:409360
Ig strand D 348..354 CDD:409360
Ig strand E 358..366 CDD:409360
Ig strand F 374..382 CDD:409360 0/7 (0%)
Ig strand G 385..393 CDD:409360 1/7 (14%)
PTKc_TrkC 532..843 CDD:270676 119/368 (32%)
Blue background indicates that the domain is not in the aligned region.

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