DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and NTRK2

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_006171.2 Gene:NTRK2 / 4915 HGNCID:8032 Length:838 Species:Homo sapiens


Alignment Length:764 Identity:187/764 - (24%)
Similarity:291/764 - (38%) Gaps:192/764 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   516 STTTTSTTTTTEKPSTTTSTSTTTTTPVPS--------TSKRTTTNAPLSTTNTPTTTTSSTTPS 572
            |....:...|.|:..:.|.:.:....|||:        .||..          ..|:.|..:...
Human   198 SANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM----------NETSHTQGSLRI 252

  Fly   573 TTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSD---C-GVT 633
            |..:|..|...|  :..|.:::.:|::.:         .:.:..|..:....:.|||   | ..|
Human   253 TNISSDDSGKQI--SCVAENLVGEDQDSV---------NLTVHFAPTITFLESPTSDHHWCIPFT 306

  Fly   634 PRTQTQPSHTTDSSPKILRTT--VLTSIRSTVH---------PRPTSTSTTTSTTTTAP------ 681
            .:...:|:.....:..||..:  :.|.|..|.|         ..||..:....|.....      
Human   307 VKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDE 371

  Fly   682 ----------PAVTAPSNEVYIGIVESSSSASPADISSTV-IANE---RDLNMEMRRMNL-VTLV 731
                      |.:...:|..|..::......:..||..|. .:||   .|:..:..|.:| |..|
Human   372 KQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAV 436

  Fly   732 LVAVGVIPLAAII-LYLVRNFVIRRRAKQSEVFDV---------CITDQQPISPVKKVDSKYQVD 786
            :|...|:....:: |:|::   :.|.:|    |.:         .:..:|.:.|..      .:.
Human   437 VVIASVVGFCLLVMLFLLK---LARHSK----FGMKDFSWFGFGKVKSRQGVGPAS------VIS 488

  Fly   787 DDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDA------------NHNRYGNNDDK 839
            :|:|.....||        ..|..|      .|.|.....||            |...:|..:.:
Human   489 NDDDSASPLHH--------ISNGSN------TPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQ 539

  Fly   840 TSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS--AQVSLKD 902
            ....:.....:|.||.||..||||.||:|:.||..:|....... :|||||::..|  |:.....
Human   540 LKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI-LVAVKTLKDASDNARKDFHR 603

  Fly   903 EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAP 967
            ||.::..| .|:::|...|.|||.:|.:::.||...|.|...|| |.....:|.|.   |.....
Human   604 EAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAE---GNPPTE 663

  Fly   968 LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEK 1032
            |:...:...|..||.||.|:|.:..||||||.||.|:..|.:.||.|||||.|:           
Human   664 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV----------- 717

  Fly  1033 NAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALP 1097
                                 |...:::                             :|....||
Human   718 ---------------------YSTDYYR-----------------------------VGGHTMLP 732

  Fly  1098 IRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHE 1162
            ||||.|||:.|..||||:|:|:.|:|||||.|.|..|:.||:..|||..:.||.....|:....|
Human   733 IRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQE 797

  Fly  1163 FYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASD-YMDVSG 1210
            .|.||..||.:|||||.:.        :.:|..:.:.:.||. |:|:.|
Human   798 VYELMLGCWQREPHMRKNI--------KGIHTLLQNLAKASPVYLDILG 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 112/330 (34%)
NTRK2NP_006171.2 LRR_8 92..150 CDD:404697
LRR 1 92..113
LRR 2 116..137
LRRCT_2 151..195 CDD:465313
Ig 205..283 CDD:472250 16/98 (16%)
Ig strand B 214..218 CDD:409353 1/3 (33%)
Ig strand C 227..230 CDD:409353 0/2 (0%)
Ig strand E 245..252 CDD:409353 1/6 (17%)
Ig strand F 262..268 CDD:409353 1/7 (14%)
Ig strand G 276..279 CDD:409353 0/2 (0%)
IgI_TrkB_d5 286..379 CDD:409441 16/92 (17%)
Ig strand A 286..294 CDD:409441 1/7 (14%)
Ig strand A' 295..298 CDD:409441 1/2 (50%)
Ig strand B 301..309 CDD:409441 2/7 (29%)
Ig strand C 312..319 CDD:409441 1/6 (17%)
Ig strand C' 322..325 CDD:409441 1/2 (50%)
Ig strand D 330..335 CDD:409441 1/4 (25%)
Ig strand E 341..349 CDD:409441 0/7 (0%)
Ig strand F 357..365 CDD:409441 1/7 (14%)
Ig strand G 368..376 CDD:409441 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..514 7/36 (19%)
PTKc_TrkB 548..835 CDD:270675 118/361 (33%)
Blue background indicates that the domain is not in the aligned region.

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