Protein Alignment Tie and Ret

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 130/405 - (32%)
• Similarity: 196/405 - (48%)
• Gaps: 94/405 - (23%)

  Fly   832 RYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSA 896
            |:.:.|.|       .:|.|..::|.::||||.||||.|..|.:::|..|.| .||||.::..|.
  Fly   756 RFESGDAK-------WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGIT-TVAVKMLKKGSN 812

  Fly   897 QV---SLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPAS 958
            .|   :|..|..::::: ||.||:.|||||..||..:||:|||..|.|.|.||.:|   .|..|.
  Fly   813 SVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR---KIECAG 873

  Fly   959 VPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDA 1023
            |.....:.|::.:.:..||..|..||.|::..::||||||||||||....:|||.|||::.|:
  Fly   874 VDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDV-- 936

  Fly  1024 ERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHD 1088
                  .|.:|                   |:                         |:|
  Fly   937 ------YEDDA-------------------YL-------------------------KRS----- 946

  Fly  1089 TIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRP 1153
                |..:|::|||||||..|::|:::|:|:||::.||:.|||::||..:..:.:...:..|.|.
  Fly   947 ----RDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRM 1007

  Fly  1154 DLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSL---HKWVD-------------DDSAA 1202
            |.|:......|:::..||..||:.||||.....|..:.|   .|::|             ||||.
  Fly  1008 DRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSAL 1072

  Fly  1203 SDYMDVSGFSEDLEH 1217
              .....|..|.|:|
  Fly  1073 --ITTELGEPESLQH 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	113/331 (34%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	115/344 (33%)