Protein Alignment Tie and Cad96Ca

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 175/628 - (27%)
• Similarity: 276/628 - (43%)
• Gaps: 153/628 - (24%)

  Fly   632 VTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIV 696
            |||.|..:.|.||..|     .|.||         |.:.:.:|...:..|...|.||..
  Fly   253 VTPTTPVRISSTTPKS-----RTKLT---------PITANNSTRVESAIPAETTTPSGG------ 297

  Fly   697 ESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRN--FVIRRRAKQ 759
            ..::|:||..|.|            ::...:..:|.|....:.:|.::.||.|.  ..|.|..|:
  Fly   298 HHNNSSSPITIFS------------LKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKK 350

  Fly   760 SEVFDVCITDQQPISPVKKVD----SKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPM 820
            ::       :::.::  ||.:    |....||..:.:..|..|......|............:..
  Fly   351 TK-------EKEELA--KKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIAT 406

  Fly   821 SQASQRDAN------------HNRYGNN--------------DDKTSLASEFH----DFERSNIR 855
            ||.|....|            ....|:|              ..:.:.|.|.:    :|.|..::
  Fly   407 SQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLK 471

  Fly   856 LKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVV 917
            ..::||||.|||||:.||.:::|:.|.| .|||||::..:.:|..||   |..:|:.|..|.|||
  Fly   472 FFNILGEGAFGQVWRCEATNINGNEGIT-TVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVV 535

  Fly   918 TLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIAC 982
            .|||.|.:.:|..:|:||..||:|.:.||::|:..:.  .:..|..::  |:...|..|...:|.
  Fly   536 HLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHY--GNTHGKSNV--LTSCDLTSFMYQVAK 596

  Fly   983 GMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFK 1047
            ||:|:..|.|:||||||||:|:..:..||:.|||.:.|:...::.
  Fly   597 GMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIY-------------------- 641

  Fly  1048 FDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFT 1112
                                            |:||.      ||   |||||||.|||..::|:
  Fly   642 --------------------------------ERKSE------GK---LPIRWMATESLYDNIFS 665

  Fly  1113 TETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHM 1177
            .::|||:|||::|||.|||||||..::..:|:|:|..|.|.:.|:..|.|.||:|..||..:|..
  Fly   666 VKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQE 730

  Fly  1178 RPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGVV 1220
            ||.||    ||.:.|.|.:..:   .||:::..|.:...:.:|
  Fly   731 RPLFA----EIIQMLDKLLHTE---MDYIELERFPDHNYYNIV 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	117/331 (35%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		PTKc	474..742	CDD:270623	120/337 (36%)