DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and KIT

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_001372213.1 Gene:KIT / 3815 HGNCID:6342 Length:977 Species:Homo sapiens


Alignment Length:1091 Identity:228/1091 - (20%)
Similarity:367/1091 - (33%) Gaps:361/1091 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   341 KPYVYFGAKLPP-IRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTS--------TTPAPVS 396
            :|.|..|...|| |.||...:....||:......:....:.|...:..|:        |..|..:
Human    26 QPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEAT 90

  Fly   397 ST-RPTASTRRPLTPVERSRSKY-------KYHMRERGLV-----PTAAPPPAAPP--------- 439
            :| :.|.:.:..|     |.|.|       |..:.:|.|.     .|....|...|         
Human    91 NTGKYTCTNKHGL-----SNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKG 150

  Fly   440 ---APPVSRTRYVGSGRPTAGLSDSIQDLKQ----------TESEVAKPVVRRVVQKVSPSSSTP 491
               .|.....|::..  |.||:  .|:.:|:          .:.|....:..:.:.||.|:....
Human   151 CQGKPLPKDLRFIPD--PKAGI--MIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAV 211

  Fly   492 LIITVLSAE------EETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRT 550
            .:::|..|.      ||.||                           |.|....::.|.||.||.
Human   212 PVVSVSKASYLLREGEEFTV---------------------------TCTIKDVSSSVYSTWKRE 249

  Fly   551 TT-------------NAPLSTTNTPTTTTSSTT----------PSTTTTSSTSTTVIPTTTKANS 592
            .:             :...:.....|.|.||..          .:.|..|:..||.:...     
Human   250 NSQQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVV----- 309

  Fly   593 IIEKDKELIRALGPALTREINIDDANN--LIV--------------FCNNTSDCGVTPRTQTQPS 641
                ||..|. :.|.:...:.::|..|  |||              :.|.|    .|.:.:..|.
Human   310 ----DKGFIN-IFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRT----FTDKWEDYPK 365

  Fly   642 HTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPAD 706
            ...:|:.:.:....||.::.|                         ....|..:|  |:|...|.
Human   366 SENESNIRYVSELHLTRLKGT-------------------------EGGTYTFLV--SNSDVNAA 403

  Fly   707 ISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQ 771
            |:..|..|.:...:...|:....|..||.| .|...|..|....  ..:|...|    |...|.|
Human   404 IAFNVYVNTKPEILTYDRLVNGMLQCVAAG-FPEPTIDWYFCPG--TEQRCSAS----VLPVDVQ 461

  Fly   772 PISPVKKVDSKYQVDDDEDEVDHQHHQHMQ----------------HHQNHQNHQNHQH------ 814
            .::.......|..|....|....:|:..::                ..:.:...|.|.|      
Human   462 TLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPL 526

  Fly   815 ---------------------HQAMPMSQASQR---DANHNRYGNNDDKTSLASEFHDFERSNIR 855
                                 :...||.:...:   :.|.|.|...|..........:|.|:.:.
Human   527 LIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLS 591

  Fly   856 LKSLLGEGNFGQVWKAEADDLSGHFG-----ATRIVAVKTIRACSAQV----SLKDEANIMRKLG 911
            ....||.|.||:|.:|.|      :|     |...||||.::. ||.:    :|..|..::..||
Human   592 FGKTLGAGAFGKVVEATA------YGLIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLG 649

  Fly   912 SHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR--------------------------- 949
            :|.|:|.|||||....|.::|.||...|.||:.||..|                           
Human   650 NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESS 714

  Fly   950 --SATN-----------ILPASVPGGRSL-------------------APLSPRTLAGFALDIAC 982
              .:||           ::|......||:                   ..|....|..|:..:|.
Human   715 CSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAK 779

  Fly   983 GMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFK 1047
            ||.::|.:..:||||||||:||.|..:.||||||::.|:          ||.:|.:::.||.   
Human   780 GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI----------KNDSNYVVKGNAR--- 831

  Fly  1048 FDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFT 1112
                                                            ||::||||||:...::|
Human   832 ------------------------------------------------LPVKWMAPESIFNCVYT 848

  Fly  1113 TETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPH 1176
            .|:|:|::||.|||:.:|||:||..: ...:..:.:.:|.|...|:.:..|.|::|..||..:|.
Human   849 FESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 913

  Fly  1177 MRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGVVYFNHRIS 1227
            .||:|.|    |.:.:.|.: .:|....|.:::..|.:.:..||..:.||:
Human   914 KRPTFKQ----IVQLIEKQI-SESTNHIYSNLANCSPNRQKPVVDHSVRIN 959

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 107/397 (27%)
KITNP_001372213.1 ig 216..306 CDD:395002 21/116 (18%)
Ig strand B 229..233 CDD:409353 2/30 (7%)
Ig strand E 267..278 CDD:409353 1/10 (10%)
Ig strand F 288..293 CDD:409353 0/4 (0%)
Ig strand G 301..304 CDD:409353 0/2 (0%)
IgI_4_SCFR 312..412 CDD:409446 22/131 (17%)
Ig strand A 312..318 CDD:409446 1/6 (17%)
Ig strand A' 322..327 CDD:409446 0/4 (0%)
Ig strand B 330..340 CDD:409446 4/9 (44%)
Ig strand C 344..351 CDD:409446 0/6 (0%)
Ig strand C' 353..356 CDD:409446 2/6 (33%)
Ig strand D 359..364 CDD:409446 0/4 (0%)
Ig strand E 373..382 CDD:409446 1/8 (13%)
Ig strand F 389..397 CDD:409446 2/9 (22%)
Ig strand G 400..411 CDD:409446 3/10 (30%)
Ig 427..503 CDD:409353 16/82 (20%)
Ig strand C 438..442 CDD:409353 1/3 (33%)
Ig strand E 471..479 CDD:409353 2/7 (29%)
Ig strand F 489..494 CDD:409353 0/4 (0%)
PTKc_Kit 554..929 CDD:270682 116/446 (26%)
Important for interaction with phosphotyrosine-binding proteins 569..571 1/1 (100%)

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