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Protein Alignment Tie and IGF1R

DIOPT Version :10

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_016877626.1	Gene:	IGF1R / 3480	HGNCID:	5465	Length:	1392	Species:	Homo sapiens

Alignment Length:	781	Identity:	186/781 - (23%)
Similarity:	290/781 - (37%)	Gaps:	223/781 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 RTTTNAP------LSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTK-------ANSIIEKDKEL 600
            ||..:.|      ||.:|:.:.......|.:....:.|..::....:       .::...|||..
Human   630 RTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIP 694

  Fly   601 IRALGPALTREINIDDA--NNLIVFC-NNTSDCGVTPRTQTQPSHTTDSSP--KILRTTVLTSIR 660
            ||.....   .|:|::.  |.....| .....|...|:|:.:.....:.:.  |:....:..||
Human   695 IRKYADG---TIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSI- 755

  Fly   661 STVHPRP-----------TSTSTTTSTTTTAPPA--VTAPSN-EVYIGIVESSSSASPADISSTV 711
              ..|||           .:|.::.|..|||...  :|.|.. |......||...    :...||
Human   756 --FVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVD----NKERTV 814

  Fly   712 IANER----------DLNMEMRRM-----NLV-TLVLVAVGVIPLAAIILYLVRNFVIRRRAKQS 760
            |:|.|          ..|.|..::     |.| ...:.|.|...:...:.:..|        .::
Human   815 ISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPR--------PEN 871

  Fly   761 EVFDVCITDQQPISPVKKVDSKY--QVDDDEDEVDHQHHQ-----------------HMQ----- 801
            .:|......:.|...:...:.||  ||:|..:.|..|.::                 .:|
Human   872 SIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLS 936

  Fly   802 -----------HHQNHQNHQNHQH-HQAMP------------MSQASQRDANHNRYGNNDDKTSL 842
                       :.|....::|..| ..|:|            |.....|..|::|.||.....|:
Human   937 GNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASV 1001

  Fly   843 ASEFH-----------DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSA 896
            ..|:.           :..|..|.:...||:|:||.|::..|..:......|| ||:||:...::
Human  1002 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETR-VAIKTVNEAAS 1065

  Fly   897 ---QVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPAS 958
               ::...:||::|::...| :||.|||...:.:|.::|||...||.|.|.||:.|......|.
Human  1066 MRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPV- 1128

  Fly   959 VPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-D 1022
                  |||.|...:...|.:||.||.|:...:.|||||||||.::..:...||.||||:.|: :
Human  1129 ------LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE 1187

  Fly  1023 AERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGH 1087
            .:..||
Human  1188 TDYYRK----------------------------------------------------------- 1193

  Fly  1088 DTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLR 1152
               |.:..||:|||:||||:..:|||.:|:|:||:||||||||...||..|:..:|:|.|.:|..
Human  1194 ---GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGL 1255

  Fly  1153 PDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEH 1217
            .|.|.......:.||..||...|.|||||    |||                   :|...|::|.
Human  1256 LDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEI-------------------ISSIKEEMEP 1297

  Fly  1218 G 1218
            |
Human  1298 G 1298

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.