Protein Alignment Tie and tor

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_061502652.1
• Gene: tor / 3290041
• VectorBaseID: AGAMI1_007799
• Length: 1147
• Species: Anopheles gambiae
• Alignment Length: 1236
• Identity: 245/1236 - (19%)
• Similarity: 404/1236 - (32%)
• Gaps: 441/1236 - (35%)

  Fly   212 AVESTSKAPSDPRSVCIRNCTKNFT-----RRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASL 271
            |..:...|.::|.....||.|....     .:|...|.::|:..||   |.:....:|.:...||
Mosquito    43 ACTAACMAGTEPGGPVDRNATGTTVPSAEELKTIGYCYKRCSEDTR---PLSAWRPLVQRQDPSL 104

  Fly   272 KAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTL--NHIADGTK--PAVMGK-GIPSKTNSMED 331
            :.....  ||:..::...:.:      |.|..|.:  ||....:|  |.:... |..::.|::.|
Mosquito   105 RINLIC--RDSTNLIIEIKPT------ALEAGGGVGGNHHHQDSKLTPKLSAPGGNQNQLNALRD 161

  Fly   332 -----DVEEEEDELKPYVYFGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTT 391
                 :..|.....:.....||. .|:..|.||.:..........:|:.:..:...||:..:...
Mosquito   162 RSASAESLESAAPARSRRAIGAD-GPLSAGQLTERQKASSGTRTNLLQPTAGKIDGPTLHGSVDA 225

  Fly   392 PAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTA 456
            .|.........:.:     |:..|..|     :|.|   ||......|..|:...:
Mosquito   226 SADEDDEADNVAVK-----VQPDREHY-----QRAL---AAEQDRTRPPVPIYLVK--------- 268

  Fly   457 GLSDSIQDL-----KQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEE---TTVGQTEALPT 513
             :.||.|:|     ..:.:.:.|      ::.::|:....:..|:|::|.|   ....|...||.
Mosquito   269 -VQDSEQELGDRIVYMSNASLVK------IENLAPNRRYNVTATMLTSEYEYYYVEKHQYRTLPH 326

  Fly   514 DESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTS- 577
            |            ..|...|....          :|..|||..|..   .....|.||:...|.
Mosquito   327 D------------YMPGIVTDIMV----------ERFETNARDSRL---VDAVISWTPAKDRTCH 366

  Fly   578 ---------STSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLI-VFCNNTSDCGV 632
                     |....:.|...:...::.  |..|:||..:         ||.:| |...||.:...
Mosquito   367 YEIVCHASYSPDFLLKPIDVQQPEVLY--KYTIKALKLS---------ANYMIAVRSKNTQNAMR 420

  Fly   633 TPRTQTQPSHTTDSSPKILRTTV-----LTSIRSTVHP-------------RPT--STSTTTSTT 677
            ..:...|..||...:.....|.|     :|::|.|..|             |||  ..|......
Mosquito   421 ESQLHWQSFHTPSCTNHTNGTQVCAPEPITNVRVTQVPLYGDHYQLNISWDRPTIAPDSYVVKVF 485

  Fly   678 TTAPPAVTAPSNEV-------YIGI-VESSSSASP------ADISSTVIANERDLN-MEMRRMN- 726
            ....|....|.|.|       .:|: :||.....|      |..|...:::|..:. :::.|::
Mosquito   486 DLHNPETEEPGNSVTKNLTGDAVGVLIESFEMFGPHFEVLVAAYSRVGVSSENTIKALQIGRVSS 550

  Fly   727 -------LVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQ 784
                   ||.::|..|.:|.|..|.:.|    :.|||||.....:.|       ...|:::.|..
Mosquito   551 ESWIRTKLVFIILTPVLMIGLLKISISL----ICRRRAKLKRYEERC-------EYFKELEQKAP 604

  Fly   785 VDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDF 849
            ||...                          :..|.|:..| |.....:..:.|..:..::..:.
Mosquito   605 VDPST--------------------------EFEPTSKQMQ-DLLATSHPFSPDLIAPINDELEI 642

  Fly   850 ERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG-ATRIVAVKTIRACSAQ---VSLKDEANIMRKL 910
            |..:|:|..:||||.||.|.|... ..||..| ..:.||||.::.|...   :..:.|..:|:.:
Mosquito   643 EMEHIKLHDMLGEGAFGLVRKGVL-QRSGDDGEPAQPVAVKMLKECPRVEDILEFRREMEVMKSV 706

  Fly   911 GSHQNVVTLLGACVES-EPHMLIMEYAMRGRLLSLLR------------------AARSATNI-- 954
            |:|.::|.::|.|.:: ...||:.||..||.||:.||                  ...|.|||
Mosquito   707 GTHPHIVGIVGHCTKNVRKMMLLTEYCGRGNLLNYLRLQWQRLLRQNRTTGTRSIGGTSGTNITA 771

  Fly   955 -LPASVP---------------------------------------------------------- 960
             ||:..|
Mosquito   772 TLPSPPPPPPPPPTRSLEMADHECLTPSLDNNKMPENVFNFDTSFVNDKKSLTYKNISDHRQTLL 836

  Fly   961 -------GG--------------RSLAPL------------------------------------ 968
                   ||              ..|.||
Mosquito   837 GVAFGLAGGSDGSSASRSPQIIENKLYPLFSDESDGDETAQLTHCTNACKNAVEIVEGTWEVGED 901

  Fly   969 ----------------------------------SPRT------------LAGFALDIACGMEYI 987
                                              ||::            |..|:..||.|||::
Mosquito   902 VKGSVRIKPCSCHGAPVDSTLTNNTVENRWYQSCSPQSEEEEDPLPNSGQLLEFSRQIALGMEFL 966

  Fly   988 AGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGS 1052
            |..::|||||||||||:..:...||.|||:|.|:..|.:
Mosquito   967 ARNKVVHRDLAARNVLVCDSNTVKIADFGLSRDIYQENL-------------------------- 1005

  Fly  1053 RYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDI 1117
                                       .:|:.:|        .|||:|:|.||:.:.::|:::|:
Mosquito  1006 ---------------------------YRKTSNG--------KLPIKWLALESMTHQVYTSQSDV 1035

  Fly  1118 WAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFA 1182
            |::||:|:||.|||.:||..::...::|.:..|.|.:.||......|:||..||:..|..||:|:
Mosquito  1036 WSYGILLYEICTLGGSPYPAISTNRLLRYLESGYRMERPKSCSELLYDLMYSCWNLHPGERPTFS 1100

  Fly  1183 Q 1183
            :
Mosquito  1101 K 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	112/515 (22%)
tor	XP_061502652.1	None