Protein Alignment Tie and tek

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_009299388.1
• Gene: tek / 30747
• ZFINID: ZDB-GENE-990415-56
• Length: 1117
• Species: Danio rerio
• Alignment Length: 1227
• Identity: 280/1227 - (22%)
• Similarity: 441/1227 - (35%)
• Gaps: 344/1227 - (28%)

  Fly    89 AAATLSETQTNATNGA----IREPP----VQLQLQQQQLQLQLQLNATAGDGESRN---SAEIFS 142
            ||||::.:..:...||    ||...    ...::.|:...|...|..|...||:.|   |..::|
Zfish    88 AAATVTWSSRSHAFGAFYCQIRNSTGRKIYTYKMLQEAAFLPESLTITVNQGENINISYSRRLYS 152

  Fly   143 PGDVDVVGDKPTTYRPSGANRPSIAPLNSAQD-RERKLMNVLAARRTALHRGGFRTRIGTTGRTA 206
            |.|        |....:|....| :|.....| ....:.|..|.....::
Zfish   153 PED--------TVIHKNGHFEHS-SPKEDISDIIHYPVTNAKAESHAGIY--------------- 193

  Fly   207 ISPSAAVESTSKAPSDP--RSVCIRNCTKNF-TRRTTASCMRQCANFTRMAMPSNGNSSVVLKGS 268
                 |:...|.|||..  ..:.:|:|...| ....|.||.| ||         ||.......|
Zfish   194 -----AIRYISAAPSSAAITRLIVRSCRAGFWGPNCTESCPR-CA---------NGGVCDDTTG- 242

  Fly   269 ASLKAAAPAGDRDTNEILFSDESSHGLFVVAKEQN---GTLNHIADGTKPAVM-------GKGIP 323
               :...|.|.|           .|...:|..|..   |......||...|::       |....
Zfish   243 ---ECVCPPGFR-----------GHTCDIVCGEGRFGAGCKERCVDGVCRALVFCLRDPYGCSCA 293

  Fly   324 SKTNSMEDDVEEEEDELKPYVYFGAKLPPIRPGGLTIK--AAEGDDD------------------ 368
            |....:..      ::..|..|:||        |.|.|  .|:|..|
Zfish   294 SGWRGLSC------NDACPDGYYGA--------GCTQKCVCAKGRCDRFRGCVCAGRHGSRCEEA 344

  Fly   369 -------HPRVLEVSVAQSTTPTITTTSTTPAP-------VSSTRPTASTRRPLTPVERSRSKYK 419
                   |.|.:|::.....:.. .:.|..|||       :::.|.|.:.....|..::|.|.::
Zfish   345 DSSPVISHLRDVEINTGVELSVN-CSASGRPAPLHGDITLITANRTTIAAVDTHTLNDQSTSVFR 408

  Fly   420 YHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKV 484
                                   |.:.|...:||....::::   ..|.|.|....|      ||
Zfish   409 -----------------------VQQVRVSSAGRWRCQVNNT---HAQVEDEFTVEV------KV 441

  Fly   485 SPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKP-STTTSTSTTTTTPV----- 543
            .|....|.::..........:..||....|   ...:|||...:| |..|.:|.|...|:
Zfish   442 PPRPQNPPVLQGSGPRHLLLLLNTEPYSGD---GPIATTTLLYRPASAHTWSSFTAHGPLVRLDN 503

  Fly   544 --PSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGP 606
              |.|  :..|...||...    ...:.......|.||....:|...|.:::.:....|...:.|
Zfish   504 LYPMT--QYLTQVQLSRPG----PGGAGQAGPAATFSTQVLELPVGVKLSAVSQTALLLSWDIAP 562

  Fly   607 A---LTREINIDDANNLIVFCNNTSDCGVTPRTQTQPS-----HTTDSSPKILRTTVLTSIRSTV 663
            |   .|.|::          |......| |.||...||     |.:|..|:......:.|.....
Zfish   563 AEQHCTYEVS----------CLQAGAPG-TLRTFQLPSNSSAMHLSDLKPRHKYQCTVRSSCGVG 616

  Fly   664 HPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESS-----SSASPADISSTVIANER------- 716
            ...|::::.|.|.....||    |:|.....|.::|     :.|....:|..||..::
Zfish   617 QNHPSASAWTLSDPELPPP----PANISIWNISDTSAVLTWAVAEGESVSRAVIRFQQVEQAQYR 677

  Fly   717 ---DLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKK 778
               :|.::.:::::...:|   |:.|...   |.::.:.:....:.:|        ..|:|.:
Zfish   678 QQVELPVQTQQLHMRFQLL---GLRPNTG---YQLQLWTVNNMGESAE--------SPPVSLM-- 726

  Fly   779 VDSKYQVDDDEDEVDHQHHQH------------------------MQHHQNHQNHQNHQHHQAMP 819
                 .:...|.......|.|                        :|..:|....:.|...:..|
Zfish   727 -----TLPQQESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIVLQLKRNTLQRRIHSILREEP 786

  Fly   820 MSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAE-ADDLSGHFGAT 883
            ....|.....|.|    ....|.:..|...:.|:|:.:.:|||||||||.||. ..|     |..
Zfish   787 AVHFSSAPPPHRR----SAVVSRSLVFPALQWSDIQFQDVLGEGNFGQVLKARIRKD-----GLR 842

  Fly   884 RIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLL 945
            ...|||.::..::|...:|   |..::.:||.|:|::.|||||.......|.:|:|..|.||..|
Zfish   843 MDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFL 907

  Fly   946 RAARSATNIL---PASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHN 1007
            |.:|    :|   ||.....|:.:.||.:.|..|:.|:|.||.|::.::.:||||||||||:..|
Zfish   908 RKSR----VLETDPAFAIAHRTASTLSSQQLLAFSADVARGMSYLSQKQFIHRDLAARNVLVGEN 968

  Fly  1008 GMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHC 1072
            .:.||.|||:|         :.||.                     |:
Zfish   969 FVAKIADFGLS---------RGQEV---------------------YV----------------- 986

  Fly  1073 SKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQ 1137
                    ||      |:|:   ||:||||.|||.|.::||.:|:|::|::|||:.:||.|||..
Zfish   987 --------KK------TMGR---LPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCG 1034

  Fly  1138 LTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHK 1194
            :|..|:..::|.|.|.:.|.....|.|.||.:||.::|..||||:|..|.:.|.|.:
Zfish  1035 MTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSLGRMLEE 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/335 (34%)
tek	XP_009299388.1	Ig_Tie2_1	25..121	CDD:463089	8/32 (25%)
		EGF_CA	<231..255	CDD:238011	9/47 (19%)
		Ig	348..437	CDD:472250	19/115 (17%)
		Ig strand B	364..368	CDD:409353	0/4 (0%)
		Ig strand C	380..384	CDD:409353	0/3 (0%)
		Ig strand E	405..409	CDD:409353	1/26 (4%)
		Ig strand F	419..424	CDD:409353	1/4 (25%)
		Ig strand G	432..435	CDD:409353	1/2 (50%)
		fn3	541..621	CDD:394996	18/90 (20%)
		FN3	633..717	CDD:214495	15/93 (16%)
		PTKc_Tie2	809..1111	CDD:133219	121/356 (34%)