Protein Alignment Tie and tie1

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_001334673.5
• Gene: tie1 / 30746
• ZFINID: ZDB-GENE-990415-55
• Length: 1122
• Species: Danio rerio
• Alignment Length: 1179
• Identity: 252/1179 - (21%)
• Similarity: 391/1179 - (33%)
• Gaps: 455/1179 - (38%)

  Fly   188 TALHRGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSV----------CIRNCTKNFTRRTTAS 242
            ||...|.|    |...:.:..|....:..|...:||...          |.:.|.:..   ..|.
Zfish   245 TACREGMF----GRNCQESCKPENGCQGLSFCLTDPYGCSCASGWHGDRCRKPCLEGM---YGAD 302

  Fly   243 CMR--QCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGT 305
            |:.  .|.|..:....|....|...:|....|:     || ..|||          .:|....|.
Zfish   303 CLLSCNCKNKGKCNRFSGCQCSTGWRGQYCEKS-----DR-APEIL----------DIASNLEGN 351

  Fly   306 LNHIADGTKPAVMGKGIPS----KTNSMEDDVEEE----EDELKPYVYFGAKLPPIRP------- 355
            ||.....|..|. |..:||    :...:|..|.:.    .|..|...:|  ::|.:.|
Zfish   352 LNSSHKITCSAT-GHPLPSHLSIELRKLESTVLKAFHTILDSKKSTAHF--EIPRLSPEHNGLWE 413

  Fly   356 ------GG-------LTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTR---PTAST 404
                  ||       ||:|........|::|..|..|.....:.:.: ...|:.||:   ...:|
Zfish   414 CRVSTNGGQDSLKFTLTVKEPPYPTAAPKLLLRSSRQLVVKAVDSYA-GDGPIVSTKLLYKQVNT 477

  Fly   405 RRPLTPV----------ERSRSKYKYHMR-------ERG--------LVPTAAPPPAAPPAPPVS 444
            ....:|:          :..:...|||:|       |.|        ::.|..|.|.|.|....|
Zfish   478 EDSWSPIIVHGSDQITLQNLKPSTKYHVRVQLARPGEGGEGPLGPEAIMETDCPEPTARPEIDSS 542

  Fly   445 ---------RTRYVGSGRPTAG----------------------LSDSIQDLKQTESEVAKPVVR 478
                     |...:|..|..:|                      ||..:.:|:..::..|  |||
Zfish   543 SLEGRNVTLRWSLIGRFREASGFLVQLYGPYGEKLWEETTFLNVLSVKLYNLEYHKNYQA--VVR 605

  Fly   479 RV---------------VQKVSPSSSTPLIITVLSAE---------------------EETTVGQ 507
            .|               :.|..|||...:....||..                     |...|||
Zfish   606 LVNCGSHGPPSRPHHIHIYKQGPSSPRNVQADALSISAVRLRWQPPEDPNGGIVKYSIEYQPVGQ 670

  Fly   508 TEALP---TDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSST 569
            :...|   ||....||       |..|:.:.||.....|.:.||.....:......||....||
Zfish   671 SSLHPWVDTDNGNKTT-------KDVTSLNGSTLYQFRVRAFSKVPGEWSSFVQAQTPGEGLSS- 727

  Fly   570 TPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTP 634
                         .||||.:....:.:|.:|:.|
Zfish   728 -------------FIPTTQQVGRPLAEDHQLLFA------------------------------- 748

  Fly   635 RTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESS 699
                                |:.|:                       |||.
Zfish   749 --------------------VVGSV-----------------------AVTC------------- 757

  Fly   700 SSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFD 764
                                        ||::        ||.:.|:.:|..|::||...:
Zfish   758 ----------------------------VTIL--------LALLALFYIRKSVLKRRRTFT---- 782

  Fly   765 VCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDAN 829
                              ||....|:.:       :|.:...............|::
Zfish   783 ------------------YQSGSGEETI-------LQFNSGTLTLTRRPKPSPEPLT-------- 814

  Fly   830 HNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKA--EADDLSGHFGATRIVAVKTIR 892
                            :...|..:|:.:.::||||||||.||  :.|      |.....|:|.::
Zfish   815 ----------------YPILEWEDIKFEDVIGEGNFGQVIKAMVKKD------GIKMSAAIKMLK 857

  Fly   893 ACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLI-MEYAMRGRLLSLLRAARSATN 953
            ..:::...:|   |..::.|||.|.|::.|:||| |:..::.| :|||..|.||..||.:|
Zfish   858 EFASENDHRDFAGELEVLCKLGQHTNIINLIGAC-ENRGYLYIAIEYAPYGNLLDFLRKSR---- 917

  Fly   954 IL---PASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDF 1015
            :|   ||......:.:.|:.:.|..||.|:|.||.|::.::.:||||||||||:..|.:.||.||
Zfish   918 VLETDPAFAKEHGTASTLTSQQLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADF 982

  Fly  1016 GMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGE 1080
            |:|        |.|:.                      |:
Zfish   983 GLS--------RGEEV----------------------YV------------------------- 992

  Fly  1081 KKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIR 1145
            ||      |:|:   ||:||||.|||.|.::||::|:|:||::||||.:||.|||..:|..|:..
Zfish   993 KK------TMGR---LPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYE 1048

  Fly  1146 RVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSG 1210
            ::|||.|.:.|:....|.|.||.:||...|:.||.|:|..:::.|.       ..|...|::::.
Zfish  1049 KLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRM-------QEARKAYVNMAL 1106

  Fly  1211 FSEDLEHGV 1219
            |......|:
Zfish  1107 FENFTYAGI 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/337 (34%)
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011
		Ig	339..429	CDD:472250	21/102 (21%)
		Ig strand B	356..360	CDD:409556	0/3 (0%)
		Ig strand C	372..376	CDD:409556	0/3 (0%)
		Ig strand E	397..401	CDD:409556	1/5 (20%)
		Ig strand F	411..416	CDD:409556	0/4 (0%)
		Ig strand G	424..427	CDD:409556	0/2 (0%)
		FN3	<427..>774	CDD:442628	80/493 (16%)
		FN3	628..720	CDD:238020	21/98 (21%)
		Protein Kinases, catalytic domain	820..1116	CDD:473864	121/378 (32%)