Protein Alignment Tie and ephb4a

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_571489.1
• Gene: ephb4a / 30688
• ZFINID: ZDB-GENE-990415-62
• Length: 987
• Species: Danio rerio
• Alignment Length: 861
• Identity: 195/861 - (22%)
• Similarity: 320/861 - (37%)
• Gaps: 281/861 - (32%)

  Fly   425 RGLVPTA-------APPPAAPPAPPVSRTRYVGS-----GRPTAGLSDSIQDLKQTESEV---AK 474
            |.||..|       |..|...|.||   ..:.|.     .:||...: .:...:.:..|:   |.
Zfish   216 RSLVQEAVGQCVANAAQPGPSPRPP---KMFCGEDGQWVDQPTTTCT-CLPGFEASHGELECRAC 276

  Fly   475 PV-VRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPT------DESTTTTSTTTTTEKPSTT 532
            || :.::.....|.|..|         |.:..|:|.:...      ..:.:.::.|..|..||:.
Zfish   277 PVGLFKMGSGTGPCSVCP---------ENSQTGETGSAACVCRSGFYRALSDSADTPCTRPPSSP 332

  Fly   533 TSTSTTTTTPVPSTSKRTTT---NAPL-----------------STTNTPTTTTS---STTPSTT 574
            .|       |||..:..:.|   :.||                 ||..:|.|..|   :..||.|
Zfish   333 RS-------PVPQVNDTSLTLEWSEPLDSGGRSDLSYSVECRMCSTPGSPCTLCSDGVNYRPSQT 390

  Fly   575 TTSSTSTTV---IPTTTKA------NSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDC 630
            .......::   .|.||.:      |.:..:.::     ||| ...|||..:.|:.|..:
Zfish   391 GIQGRRVSIWGLRPHTTYSFTVMALNGVSAQSQQ-----GPA-GETINITTSPNVPVLVS----- 444

  Fly   631 GVTPRTQTQPSHT------TDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSN 689
            |:...|.|:.|.|      |.|..:||:    ..||.....|.:..::.        ..:.:.:|
Zfish   445 GLRKSTATESSLTLYWNTPTQSHYRILQ----YQIRYCEKERGSEENSC--------HYMESNNN 497

  Fly   690 EVYIGIVESSS---------------SASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIP 739
            ||.:..:..::               |...|.:..| :.:|.|.:..:    |||.:|:|:|::.
Zfish   498 EVVLSDLRRATQYEVQVRARTFAGYGSFGKAILFRT-LPDEDDSSSPL----LVTGILIAMGMLL 557

  Fly   740 LAAII---LYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQ 801
            |..:|   :|.:|        ||:...|                         .|:..::.|::
Zfish   558 LIIVIGAAIYCIR--------KQNNYKD-------------------------PELSDKNGQYL- 588

  Fly   802 HHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEF-HDFERSNIRLKSLLGEGNF 865
                              |.|..:...:...|   :|......|| .:.:.|.::::.::|.|.|
Zfish   589 ------------------MGQGVKVYIDPFTY---EDPNEAVREFAKEIDVSCVKIEEVIGAGEF 632

  Fly   866 GQVWKAEADDLSGHFGATRI-------VAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLL 920
            |:|.:          |..||       ||:||::........:|   ||:||.:. .|.|::.|.
Zfish   633 GEVCR----------GRLRIPGKKENYVAIKTLKGGYTDKQRRDFLAEASIMGQF-QHPNIIHLE 686

  Fly   921 GACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGME 985
            |....|.|.|::.|:...|.|.|.||            :..|:    .:|..|.|....||.||:
Zfish   687 GIITASCPVMILTEFMENGALDSFLR------------LNDGQ----FTPIQLVGMLRGIASGMK 735

  Fly   986 YIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDF 1050
            |::....|||||||||:|::.|.:||:.|||:|        |..||.::
Zfish   736 YLSEMSYVHRDLAARNILVNSNLVCKVSDFGLS--------RFLQENSS---------------- 776

  Fly  1051 GSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTET 1115
                     ..|:....|                      ||   :||||.|||::.:..||..:
Zfish   777 ---------DPTYTSSLG----------------------GK---IPIRWTAPEAIAFRKFTCAS 807

  Fly  1116 DIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPS 1180
            |:|::|||:||:.:.|..||..::.::||..:.|..|...|.:.....:.||..||.||...||.
Zfish   808 DVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCSTYLHQLMLDCWQKERTARPR 872

  Fly  1181 FAQSRLEITRSLHKWV 1196
            ||    .|..:|.|.:
Zfish   873 FA----NIVSALDKLI 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	96/338 (28%)
ephb4a	NP_571489.1	EphR_LBD	26..199	CDD:470656
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	319..340		8/27 (30%)
		fn3	339..418	CDD:394996	15/78 (19%)
		FN3	440..533	CDD:238020	18/109 (17%)
		EphA2_TM	547..618	CDD:464211	19/125 (15%)
		PTKc_EphR_B	616..884	CDD:173638	101/356 (28%)
		SAM_EPH-B4	914..980	CDD:188953