Protein Alignment Tie and Styk1

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_766479.1
• Gene: Styk1 / 243659
• MGIID: 2141396
• Length: 429
• Species: Mus musculus
• Alignment Length: 338
• Identity: 78/338 - (23%)
• Similarity: 131/338 - (38%)
• Gaps: 90/338 - (26%)

  Fly   891 IRACSAQVSLKDEANIMRK------LGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR 949
            ::|....|.|::..:.:.:      ||.|:|:|.|.|.|.|..|..:::|..:.|.|||.|...|
Mouse   151 LKALEDPVGLQEVQDFIGRIQFYQYLGKHKNLVQLEGCCTERLPLYMMLEDVVPGDLLSFLWTCR 215

  Fly   950 SATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICD 1014
            .....:..      .|..|:.:.:......|...:|::..:.:.|.|:||||:|:..:...|:|.
Mouse   216 RDVMTMDG------LLYDLTEKQIYHIGKQILLALEFLQEKHLFHGDVAARNILIQSDLTPKLCH 274

  Fly  1015 FGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHG 1079
            .|::.::.|
Mouse   275 LGLAYEVHA-------------------------------------------------------- 283

  Fly  1080 EKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVI 1144
                 ||..:..:...:|::|:|||.|.....:...|||:|||:|:|:.|||:.||.::....::
Mouse   284 -----HGAISSARSSTIPLKWLAPERLLLRPASIRGDIWSFGILLYEMVTLGAPPYPEVPPTSIL 343

  Fly  1145 RRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQ--SRLE-ITRSLHKWVDDDSAASD-- 1204
            :.:.:......|....|..||:|..||......||...|  .||| .:||.     ||.|...
Mouse   344 QYLQRKKIMKRPSSCSHAMYNIMKCCWRWSEDSRPLLGQLLQRLEAASRSA-----DDKAVLQVP 403

  Fly  1205 -------YMDVSG 1210
                   |.||:|
Mouse   404 ELVVPELYADVAG 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	65/297 (22%)
Styk1	NP_766479.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..83
		Protein Kinases, catalytic domain	123..388	CDD:473864	67/303 (22%)