DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and FLT4

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:XP_011532780.1 Gene:FLT4 / 2324 HGNCID:3767 Length:1440 Species:Homo sapiens


Alignment Length:396 Identity:113/396 - (28%)
Similarity:177/396 - (44%) Gaps:121/396 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   843 ASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGAT-RIVAVKTIR---ACSAQVSLKDE 903
            ||:: :|.|..:.|..:||.|.||:|.:|.|..:  |.|:: ..||||.::   ..|...:|..|
Human   912 ASQW-EFPRERLHLGRVLGYGAFGKVVEASAFGI--HKGSSCDTVAVKMLKEGATASEHRALMSE 973

  Fly   904 ANIMRKLGSHQNVVTLLGACVESE-PHMLIMEYAMRGRLLSLLRAARSATNILPASVP------- 960
            ..|:..:|:|.|||.|||||.:.: |.|:|:|:...|.|.:.|||.|.|.:......|       
Human   974 LKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFR 1038

  Fly   961 -----------------------------GGRSLAP--------LSPRT---LAGFALDIACGME 985
                                         |.|..:|        |||.|   |..::..:|.|||
Human  1039 AMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGME 1103

  Fly   986 YIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL--DAERMRKEQEKNAANDLMRHNAHKFKF 1048
            ::|.|:.:||||||||:||..:.:.||||||::.|:  |.:.:||...:                
Human  1104 FLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSAR---------------- 1152

  Fly  1049 DFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTT 1113
                                                           ||::||||||:...::||
Human  1153 -----------------------------------------------LPLKWMAPESIFDKVYTT 1170

  Fly  1114 ETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHM 1177
            ::|:|:||::||||.:||::||..: ...|..:|:..|.|...|:.:......:|..||..:|..
Human  1171 QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKA 1235

  Fly  1178 RPSFAQ 1183
            ||:|::
Human  1236 RPAFSE 1241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 109/383 (28%)
FLT4XP_011532780.1 Ig_2 214..301 CDD:464026
IgI_VEGFR 307..406 CDD:409448
Ig strand A 307..311 CDD:409448
Ig strand A' 317..321 CDD:409448
Ig strand B 323..332 CDD:409448
Ig strand C 339..344 CDD:409448
Ig strand C' 347..349 CDD:409448
Ig strand D 353..361 CDD:409448
Ig strand E 366..374 CDD:409448
Ig strand F 384..390 CDD:409448
Ig strand G 395..401 CDD:409448
IgI_VEGFR-3 408..495 CDD:409449
Ig strand A 409..414 CDD:409449
Ig strand A' 419..424 CDD:409449
Ig strand B 426..437 CDD:409449
Ig strand C 441..447 CDD:409449
Ig strand C' 449..452 CDD:409449
Ig strand D 455..457 CDD:409449
Ig strand E 459..464 CDD:409449
Ig strand F 472..480 CDD:409449
Ig strand G 486..495 CDD:409449
Ig_3 636..732 CDD:464046
Ig 755..842 CDD:472250
Ig strand B 772..776 CDD:409353
Ig strand C 785..789 CDD:409353
Ig strand E 808..812 CDD:409353
Ig strand F 822..827 CDD:409353
VEGFR-2_TMD 847..881 CDD:375470
PTKc_VEGFR3 914..1253 CDD:270680 111/394 (28%)
Blue background indicates that the domain is not in the aligned region.

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