DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and FLT3

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_004110.2 Gene:FLT3 / 2322 HGNCID:3765 Length:993 Species:Homo sapiens


Alignment Length:489 Identity:133/489 - (27%)
Similarity:200/489 - (40%) Gaps:148/489 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   806 HQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFE--------RSNIRLKSLLGE 862
            |:..:..::...:.|.|.:         |::|::.... :|.::|        |.|:....:||.
Human   564 HKYKKQFRYESQLQMVQVT---------GSSDNEYFYV-DFREYEYDLKWEFPRENLEFGKVLGS 618

  Fly   863 GNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQVSLKDEANIMRKLGSHQNVVTLLGACV 924
            |.||:|..|.|..:| ..|.:..||||.::.   .|.:.:|..|..:|.:||||:|:|.|||||.
Human   619 GAFGKVMNATAYGIS-KTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT 682

  Fly   925 ESEPHMLIMEYAMRGRLLSLLRAARSA-----TNILP---------------ASVPGGR------ 963
            .|.|..||.||...|.||:.||:.|..     |.|..               :|:||.|      
Human   683 LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHP 747

  Fly   964 -------------------------------SLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDL 997
                                           .|..|:...|..||..:|.|||::..:..|||||
Human   748 DSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDL 812

  Fly   998 AARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHT 1062
            ||||||:.|..:.||||||::.|:.::          :|.::|.||.                  
Human   813 AARNVLVTHGKVVKICDFGLARDIMSD----------SNYVVRGNAR------------------ 849

  Fly  1063 FGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEI 1127
                                             ||::|||||||...::|.::|:|::||:||||
Human   850 ---------------------------------LPVKWMAPESLFEGIYTIKSDVWSYGILLWEI 881

  Fly  1128 ATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRS 1191
            .:||..||..: ......:.:..|.:.|.|..:..|.|.:|..||..:...||||.    .:|..
Human   882 FSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP----NLTSF 942

  Fly  1192 LHKWVDDDSAASDYMDVSGFSEDLEHGVVYFNHR 1225
            |...:.|...|. |.:|.|...:..|  .|.|.|
Human   943 LGCQLADAEEAM-YQNVDGRVSECPH--TYQNRR 973

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 113/389 (29%)
FLT3NP_004110.2 ig 256..345 CDD:395002
Ig strand B 268..272 CDD:409448
Ig strand C 282..286 CDD:409448
Ig strand E 314..317 CDD:409448
Ig strand F 327..332 CDD:409448
Ig strand G 340..343 CDD:409448
Protein Kinases, catalytic domain 572..947 CDD:473864 123/450 (27%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand 591..597 1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

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