DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and FLT1

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_002010.2 Gene:FLT1 / 2321 HGNCID:3763 Length:1338 Species:Homo sapiens


Alignment Length:1460 Identity:308/1460 - (21%)
Similarity:478/1460 - (32%) Gaps:563/1460 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 SCW----LLLLLLVALLLAEAIVAAAAATLSETQTNATNGA-IREPPVQLQLQQQQLQ----LQL 123
            |.|    ||..||..|||                |.:::|: :::|.:.|:..|..:|    |.|
Human     3 SYWDTGVLLCALLSCLLL----------------TGSSSGSKLKDPELSLKGTQHIMQAGQTLHL 51

  Fly   124 QLNATAGDGESRNSAEIFSPGDVDVVGDK-PTTYRPSGANRP---SIAPLNSAQDRERKLMNVLA 184
            |..     ||:.:...:  |..|....:: ..|....|.|..   |...||:||           
Human    52 QCR-----GEAAHKWSL--PEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQ----------- 98

  Fly   185 ARRTALHRGGFRTR-------------------IGTTGRTAISPSAAVESTSKAPSDPRSVCIRN 230
                |.|.|.:..:                   |..|||      ..||..|:.|.      |.:
Human    99 ----ANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGR------PFVEMYSEIPE------IIH 147

  Fly   231 CTKNFTRRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDR---DTNEILFSDESS 292
            .|:.  |.....|        |:..|   |.:|.|| ...|....|.|.|   |:.:......::
Human   148 MTEG--RELVIPC--------RVTSP---NITVTLK-KFPLDTLIPDGKRIIWDSRKGFIISNAT 198

  Fly   293 H---GLFVVAKEQNGTL---NHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLP 351
            :   ||.......||.|   |::..            .:||::.|                .::.
Human   199 YKEIGLLTCEATVNGHLYKTNYLTH------------RQTNTIID----------------VQIS 235

  Fly   352 PIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRR---------- 406
            ..||    :|...|   |..||..:   :|||..|....|.:........||.||          
Human   236 TPRP----VKLLRG---HTLVLNCT---ATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHAN 290

  Fly   407 ---PLTPVERSRSKYK-------------------YHM----------RERGLVPTAAPPPA--- 436
               .:..:::.::|.|                   .|:          |::.::.|.|...:   
Human   291 IFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355

  Fly   437 -----APPAPPV-----------SRTRYVGSGRPTAGLSDSIQDLKQ------------TESEVA 473
                 |.|:|.|           ...||:     |.|.|..|:|:.:            .:|.|.
Human   356 SMKVKAFPSPEVVWLKDGLPATEKSARYL-----TRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415

  Fly   474 KPVVRRVVQKVSPS------SSTP----------LIIT--------------------------- 495
            |.:...::..|.|.      ||.|          .|:|                           
Human   416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480

  Fly   496 -VLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPS-----TSKRTTT-- 552
             ..|..||:.:...::...:...:.|......|..:...||.....:.:..     .|.:..|  
Human   481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVG 545

  Fly   553 -NAPLSTTNTPT--TTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKE--LIRALG------- 605
             |.....|:.|.  .......|:.......|.||       |..:.:|..  |:|.:.       
Human   546 RNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTV-------NKFLYRDVTWILLRTVNNRTMHYS 603

  Fly   606 -----PALTREINIDDANNLIVFCNNTSDCG--------------------VTPRTQTQP---SH 642
                 .|:|:|.:|  ..||.:...:..|.|                    :|.|.|..|   .:
Human   604 ISKQKMAITKEHSI--TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRN 666

  Fly   643 TTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPA--------------VTAPSNEVY- 692
            .:|.:..|..:|.|....:.| |.|..|....:......|.              ||.....|| 
Human   667 LSDHTVAISSSTTLDCHANGV-PEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYH 730

  Fly   693 ------IGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNF 751
                  .|.||||:..       ||.......|:|     |:||....|     ||.:.:|:...
Human   731 CKATNQKGSVESSAYL-------TVQGTSDKSNLE-----LITLTCTCV-----AATLFWLLLTL 778

  Fly   752 VIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQ 816
            .||:..:.|             |.:|.......:|.||..:|.|                   .:
Human   779 FIRKMKRSS-------------SEIKTDYLSIIMDPDEVPLDEQ-------------------CE 811

  Fly   817 AMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG 881
            .:|..                     ||:: :|.|..::|...||.|.||:|.:|.|      ||
Human   812 RLPYD---------------------ASKW-EFARERLKLGKSLGRGAFGKVVQASA------FG 848

  Fly   882 -----ATRIVAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACV-ESEPHMLIMEYAM 937
                 ..|.||||.::   ..|...:|..|..|:..:|.|.|||.|||||. :..|.|:|:||..
Human   849 IKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 913

  Fly   938 RGRLLSLLRAAR--------SATNILPA-----------------SVPGGRSLA----------- 966
            .|.|.:.|::.|        :|.::.|.                 ||....|.|           
Human   914 YGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLS 978

  Fly   967 --------------PLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGM 1017
                          |::...|..::..:|.|||:::.|:.:||||||||:||..|.:.||||||:
Human   979 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGL 1043

  Fly  1018 SIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKK 1082
            :.|:         .||.  |.:|..                                        
Human  1044 ARDI---------YKNP--DYVRKG---------------------------------------- 1057

  Fly  1083 SHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRR 1146
                 ||     .||::||||||:...:::|::|:|::|::||||.:||.:||..: ...:...|
Human  1058 -----DT-----RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSR 1112

  Fly  1147 VPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS-- 1209
            :.:|:|...|:.|..|.|.:|..|||::|..||.||:...::...|...|..|  ..||:.::  
Human  1113 LREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQD--GKDYIPINAI 1175

  Fly  1210 ------------GFSEDLEHGVVYFNHRIS 1227
                        .||||      :|...||
Human  1176 LTGNSGFTYSTPAFSED------FFKESIS 1199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 111/388 (29%)
FLT1NP_002010.2 IG_like 143..219 CDD:214653 21/95 (22%)
IgI_VEGFR 230..330 CDD:409448 20/125 (16%)
Ig strand A 230..234 CDD:409448 1/19 (5%)
Ig strand A' 240..244 CDD:409448 1/3 (33%)
Ig strand B 246..255 CDD:409448 3/11 (27%)
Ig strand C 262..267 CDD:409448 1/4 (25%)
Ig strand C' 270..272 CDD:409448 0/1 (0%)
Ig strand D 275..283 CDD:409448 4/7 (57%)
Ig strand E 290..298 CDD:409448 0/7 (0%)
Ig strand F 308..314 CDD:409448 0/5 (0%)
Ig strand G 319..325 CDD:409448 0/5 (0%)
IgI_VEGFR-1 333..424 CDD:409499 17/95 (18%)
Ig strand A 333..337 CDD:409499 0/3 (0%)
Ig strand A' 343..348 CDD:409499 1/4 (25%)
Ig strand B 353..361 CDD:409499 0/7 (0%)
Ig strand C 365..371 CDD:409499 2/5 (40%)
Ig strand C' 373..376 CDD:409499 0/2 (0%)
Ig strand D 382..386 CDD:409499 2/8 (25%)
Ig strand E 388..393 CDD:409499 1/4 (25%)
Ig strand F 401..410 CDD:409499 0/8 (0%)
Ig strand G 413..424 CDD:409499 2/10 (20%)
Ig_3 427..539 CDD:464046 13/111 (12%)
IG_like 568..640 CDD:214653 15/80 (19%)
Ig strand B 573..577 CDD:409353 0/3 (0%)
Ig strand C 586..594 CDD:409353 2/7 (29%)
Ig strand E 619..623 CDD:409353 2/3 (67%)
Ig strand F 633..638 CDD:409353 0/4 (0%)
I-set 661..748 CDD:400151 19/94 (20%)
Ig strand B 679..682 CDD:409353 1/2 (50%)
Ig strand C 691..695 CDD:409353 1/3 (33%)
Ig strand E 714..718 CDD:409353 0/3 (0%)
Ig strand F 728..733 CDD:409353 2/4 (50%)
PTKc_VEGFR1 819..1157 CDD:271109 114/405 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..982 5/41 (12%)

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