Protein Alignment Tie and F09A5.2

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001360730.1
• Gene: F09A5.2 / 181440
• WormBaseID: WBGene00008599
• Length: 867
• Species: Caenorhabditis elegans
• Alignment Length: 929
• Identity: 189/929 - (20%)
• Similarity: 338/929 - (36%)
• Gaps: 330/929 - (35%)

  Fly   446 TRYVGSGRPT-AGLSD-SIQDLKQTESEVAKPV--VRRVVQKVSPSSSTPLIITVLSAEEETTVG 506
            |..:.|..|: :.|:: ...:||:.||......  .|||::.:|..|...:::.:.:...|..:.
 Worm     7 TLLIDSSNPSYSHLTEYRFDNLKREESRSTSLFGDRRRVMKILSGFSLIIIVVFIFATSHEQALS 71

  Fly   507 QTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTP 571
            .|..|        ||:|.:|.......:..||..:|    .|....|:..||.......|.:.:.
 Worm    72 TTGDL--------TSSTQSTTHGGVVFTYPTTRKSP----GKGCVLNSQRSTPKNLKQYTGNISD 124

  Fly   572 STTT--TSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTS-DCG-- 631
            :...  .||...|.:.|    |::|.|..:.:            :.:..:::.|.|.|| .|.
 Worm   125 ACLAGIKSSNCKTWLMT----NAVILKYSDDV------------VSNCPSILEFVNKTSLSCSGK 173

  Fly   632 -----VTPRTQTQPS---HTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPS 688
                 :.|::.:..|   |:.|.:...|.       |:..:...:.|..:||...|       |.
 Worm   174 SQIQYMYPQSDSASSDCNHSYDFNSNALN-------RAIYNFNYSKTLISTSYANT-------PG 224

  Fly   689 NEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLV---------------------L 732
            ..:|..:::         |.:.|  |:..:.::...:|:.|.:                     |
 Worm   225 FAMYTFLLK---------IMNCV--NKNGIKLDAGILNIFTDMTYIDLCESDVFMSSFPDTLNKL 278

  Fly   733 VAVGVIPLAAIILYLVRNFVIRRRAKQSE--------------------------------VFDV 765
            :..|         |:|:.:.:.:..:.::                                .|::
 Worm   279 IEAG---------YIVKFYFLNQNLQDTQKNVENVLAGCKYMNSRSYCEIVDWSYHSENPNEFEI 334

  Fly   766 CITDQQPISPVKKVDSKYQVDD------------------------------------------- 787
            ||.|.||..  ||.|..:.|.:
 Worm   335 CIPDSQPSG--KKEDFNWHVTELLLIIGIPCISLTICCIAFFVCCLKCAKLKMAMMRMNVFSNDT 397

  Fly   788 ----DEDEVDHQ--------------------HHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDA 828
                ||.|:..:                    :.|...|..:..|:.:.|     .::.|:::|
 Worm   398 HQNPDEMELKKRWIGMRKKFNKDVENGSCKELNTQKWSHFASANNYMDIQ-----ALANANKKD- 456

  Fly   829 NHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWK-------------------AEAD 874
                ....|.|..|..|.|           |||.|.|..|:|                   .|::
 Worm   457 ----IWEIDTKNLLVQEDH-----------LLGNGAFANVYKGIVKGKIPLLVVNNSLNMTVESE 506

  Fly   875 DLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVES--EPHMLIME 934
            : :||:.|    |:|.:.|.:.:.:..|   |.:.|::||.|.:|:::|| ||.:  || ::::|
 Worm   507 N-NGHYEA----AIKKLPAHADEQNHLDFFHEIDFMKRLGHHPHVISMLG-CVSNPYEP-LIVVE 564

  Fly   935 YAMRGRLLSLLRAAR-----SATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVH 994
            |..||.||..||..:     :.|:..|....     ..|..:.|...|..:|.||.|:|.:..:|
 Worm   565 YCARGDLLKFLRRHKDYVLMNKTDDCPIEAD-----MCLRIKDLVSIAWQVADGMSYLASKNFIH 624

  Fly   995 RDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHW 1059
            |||||||:||..:...|:.|||:...:|:.....:                     |.|
 Worm   625 RDLAARNILLTKSLTAKVSDFGLCRYMDSALYTAK---------------------GGR------ 662

  Fly  1060 QHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVL 1124
                                                |||:||:.|:|:.:.|:|:||:|:||::|
 Worm   663 ------------------------------------LPIKWMSVEALKLYEFSTKTDVWSFGVLL 691

  Fly  1125 WEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEIT 1189
            :||.::|..||..:...:::..:..|.|...|.:..:|.:|:|.:||.::|..||.|.:.|.|||
 Worm   692 FEIFSMGDVPYPTIQQVDMLEHLLAGGRLSQPLKCPNEIFNIMQKCWAEKPEDRPEFNEMRGEIT 756

  Fly  1190 RSLHKWVDDDSAASDYMDV 1208
            ..|:  :||:|..  |:.|
 Worm   757 VMLN--LDDESYG--YLSV 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	94/357 (26%)
F09A5.2	NP_001360730.1	PTKc	473..752	CDD:270623	93/353 (26%)