Protein Alignment Tie and kin-16

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_496017.1
• Gene: kin-16 / 174499
• WormBaseID: WBGene00002200
• Length: 495
• Species: Caenorhabditis elegans
• Alignment Length: 579
• Identity: 149/579 - (25%)
• Similarity: 210/579 - (36%)
• Gaps: 185/579 - (31%)

  Fly   684 VTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLV 748
            :..|:.:..|.....|....||:...:|        .::|    .|:..|..|::.|.|.|.:||
 Worm    28 INLPNQQDVIYRYTRSERGDPAEKEGSV--------FKLR----TTVFFVVYGLLVLLAFIAFLV 80

  Fly   749 RNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQ 813
            ...   ||:|..|             ..|.:.......|..|..|
 Worm    81 WRL---RRSKTQE-------------KRKNMALMNIYSDLRDTGD-------------------- 109

  Fly   814 HHQAMPMSQASQRDANHN-RYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKA---EAD 874
               ||| .:...|..|.. .|.....:..:|||       |:..||:||.||||.|.|.   .|.
 Worm   110 ---AMP-EELKNRPLNDKLDYLPYKKQYEIASE-------NLENKSILGSGNFGVVRKGILKMAS 163

  Fly   875 DLSGHFGATRI-VAVKTIRAC---SAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPH----ML 931
            ..:......|: ||||:...|   |....|..|..:|..:|...||:.|:|| |.||..    ::
 Worm   164 PKNEEEKKMRLTVAVKSAANCYDISQTSMLAAELRLMCSIGRFPNVLALVGA-VTSELRKGRLLI 227

  Fly   932 IMEYAMRGRLLSLLRAARSA-------------TNILPASVPG----------------GRSLAP 967
            :.||...|.:...|...|:.             :.:.|.|...                ..||..
 Worm   228 VTEYIDCGDIRKYLIDHRNVFQDHLIEDKTEPDSYLTPISAKRKNYVFKNTDENSDYVIKESLDS 292

  Fly   968 LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEK 1032
            |:...|..|.|.||.||:|:|...:||||||.|||||..|...:|.||||:
 Worm   293 LTTSDLLSFGLQIANGMQYLASIPMVHRDLALRNVLLKKNKTIRIADFGMA-------------- 343

  Fly  1033 NAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALP 1097
                     ..|:.|    |.||.|.              :||.|                  :|
 Worm   344 ---------RTHENK----SYYIPQK--------------TKDAP------------------VP 363

  Fly  1098 IRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHE 1162
            :|||:||:.....||.::|:|:|||.|:||.|||..||..:....:...:..|.|...|:....|
 Worm   364 VRWMSPEAFDTMKFTEKSDVWSFGICLYEIFTLGQLPYPDVPSERIYEYMHSGRRCPQPQHCHVE 428

  Fly  1163 FYNLMSRCWHKEPHMRPSFAQ-------------SRL------------EITRSLHKWV 1196
            .|:||..|||::|.:||:|:.             |:|            |..|.|..|:
 Worm   429 LYDLMKLCWHEKPELRPNFSNCVEYFIGHMKKSASKLLENVDEMLRVEAENQRKLEDWI 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/368 (30%)
kin-16	NP_496017.1	PTKc	145..454	CDD:270623	108/368 (29%)