Protein Alignment Tie and kin-15

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_741035.2
• Gene: kin-15 / 174498
• WormBaseID: WBGene00002199
• Length: 488
• Species: Caenorhabditis elegans
• Alignment Length: 564
• Identity: 120/564 - (21%)
• Similarity: 210/564 - (37%)
• Gaps: 208/564 - (36%)

  Fly   688 SNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNF- 751
            ||..:....|:...:|  .||:.:..::.          .:..:|:.:.:| |.::|:||.:.:
 Worm    24 SNSTFESFTENPHISS--QISNVLYMDQM----------FIIYILICILLI-LISVIVYLSKRYS 75

  Fly   752 ---------VIRRRA-----KQSEVFDV-------CITDQQPI--SPVK------KVDSKYQVDD 787
                     :..||:     .:|.::|:       .:.::.||  .|:.      :.|.::::|.
 Worm    76 QQMMQSSDNITNRRSNPEVRNKSNIYDLPPLLDVTSVNEETPIVKRPINERIENLEFDPRFEIDQ 140

  Fly   788 DEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERS 852
            .:.|:                                           ::||
 Worm   141 AKLEI-------------------------------------------SEDK------------- 149

  Fly   853 NIRLKSLLGEGNFGQVW---------KAEADDLSGHFGATRIVAVKTIR---ACSAQVSLKDEAN 905
                   ||.|.||:|.         ..|.|.|.     ...||||...   ..:.:..::||..
 Worm   150 -------LGSGFFGEVCYGLLSMRTSNTETDTLQ-----KLSVAVKQSNDPTQENQEKMIEDETK 202

  Fly   906 IMRKLGSHQNVVTLLGACVE---SEPHMLIMEYAMRGRLLSLLRAARSATN----------ILPA 957
            :|..:|.:.|::.::||...   |..::||:|:...|.||..|...:|...          :||.
 Worm   203 LMCAIGRNPNILAIIGAVTANSGSARNLLIVEFVECGDLLKFLEEKKSIFKDELVYEKNGYLLPK 267

  Fly   958 SVPG-------------GRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGM 1009
            |:..             ..||..|....|..|:..||.||||:|....||||||.|||||:.|..
 Worm   268 SIRRKTYMFNENEDDVIEESLDSLCTSDLLSFSYQIAEGMEYLASIPCVHRDLALRNVLLNKNKT 332

  Fly  1010 CKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSK 1074
            .:|.|||:                         |.|::.|       .:::.|.|.|.
 Worm   333 IRIADFGL-------------------------ARKYQVD-------GYYRITKGVGT------- 358

  Fly  1075 DQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLT 1139
                                .:|.||||||.::....|.::|:|::|:.|:|:.:||..|||.::
 Worm   359 --------------------PMPARWMAPEVMREGKCTEKSDVWSYGVSLYEMFSLGELPYSNVS 403

  Fly  1140 GREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQ 1183
            ..:|...|.||.:..:|:....:.|:.|.:.|:.:...||||::
 Worm   404 NSDVFEHVVQGNQLPMPQYCHPKMYDRMKQFWNFDATFRPSFSK 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	96/366 (26%)
kin-15	NP_741035.2	PTKc	148..453	CDD:270623	98/384 (26%)