Protein Alignment Tie and Flt3

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_034359.2
• Gene: Flt3 / 14255
• MGIID: 95559
• Length: 1000
• Species: Mus musculus
• Alignment Length: 123
• Identity: 27/123 - (21%)
• Similarity: 47/123 - (38%)
• Gaps: 20/123 - (16%)

  Fly   123 IKLTGNPIPSWVNRLA-RIGKFSGFMCN------CVLPATINATRFGNNRVN---QDKSCEAENE 177
            :|.|.:.|||.:..:: ..|..  |:.|      .:.||..:...|..|.:.   .|...| ::.
Mouse    39 VKFTPDNIPSEILSVSWHFGDI--FILNGNPDSPLIFPAYEDKVSFDKNTLALELWDLKLE-DSG 100

  Fly   178 KKKLTSVSSRERSTIATPS-------SSSSSPSVQVRGRSRKRRPRALQPSSPLTLGS 228
            ...||.::||..|.....|       ...||.:...:|.......:.::.:|||:..|
Mouse   101 SYSLTVITSRGNSHKGETSLQVFALIEGESSANFTSKGNGNVTSVQWMKDNSPLSSSS 158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..67		6/23 (26%)
		ig	256..346	CDD:395002
		Ig strand B	269..273	CDD:409353
		Ig strand C	283..287	CDD:409353
		Ig strand E	315..318	CDD:409353
		Ig strand F	328..333	CDD:409353
		7tm_GPCRs	<491..>586	CDD:475119
		Protein Kinases, catalytic domain	573..950	CDD:473864
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	968..1000