DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and Flt1

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_034358.2 Gene:Flt1 / 14254 MGIID:95558 Length:1333 Species:Mus musculus


Alignment Length:1322 Identity:289/1322 - (21%)
Similarity:449/1322 - (33%) Gaps:463/1322 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 VALLLAEAIVAA---AAATLSETQTNATNGAIREPPVQLQLQQQQLQLQLQLNATA-GDGESRNS 137
            :.||..||.|..   ....|:..|||........||..::|...|   .|.||.|| .:..:|..
Mouse   203 IGLLNCEATVNGHLYQTNYLTHRQTNTILDVQIRPPSPVRLLHGQ---TLVLNCTATTELNTRVQ 264

  Fly   138 AEIFSPGDVDVVGDKPTTYRPSGANR-----------PSIAPLNSAQDRERKLMNVLAARRTALH 191
            .....||        ..|.|.|...|           .|:..:|:.:.|::.|...         
Mouse   265 MSWNYPG--------KATKRASIRQRIDRSHSHNNVFHSVLKINNVESRDKGLYTC--------- 312

  Fly   192 RGGFRTRIGTTGRTAISPSAAVESTSKAPSDPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMP 256
                |.:.|::.::.        :||....:...:.::: .|...:.|||.......:....|.|
Mouse   313 ----RVKSGSSFQSF--------NTSVHVYEKGFISVKH-RKQPVQETTAGRRSYRLSMKVKAFP 364

  Fly   257 SNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTLNHIAD-----GTKPA 316
            |   ..:|.     ||..:||..:....::      ||..::.|:.  |.....|     |.|.:
Mouse   365 S---PEIVW-----LKDGSPATLKSARYLV------HGYSLIIKDV--TTEDAGDYTILLGIKQS 413

  Fly   317 VMGKGIPSKTNSMEDDVEEEEDELKPYVY----FGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSV 377
            .:.|.:   |.::..:|       ||.:|    .....||:.|.|           ..:||..:|
Mouse   414 RLFKNL---TATLIVNV-------KPQIYEKSVSSLPSPPLYPLG-----------SRQVLTCTV 457

  Fly   378 AQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHM---RERGLVPTAAPPPAAPP 439
            .....||||..                   ..|...:.||.:|..   .|...:..         
Mouse   458 YGIPRPTITWL-------------------WHPCHHNHSKERYDFCTENEESFILD--------- 494

  Fly   440 APPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETT 504
                          |::.|.:.|:.:.| ...|.:...:.|...|...|.||.|.:..:..:..|
Mouse   495 --------------PSSNLGNRIESISQ-RMTVIEGTNKTVSTLVVADSQTPGIYSCRAFNKIGT 544

  Fly   505 VGQT----------------EALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTN 553
            |.:.                |.:|.:......|..                   |.....|..|.
Mouse   545 VERNIKFYVTDVPNGFHVSLEKMPAEGEDLKLSCV-------------------VNKFLYRDITW 590

  Fly   554 APLSTTNTPTTTTSSTTPSTTTTSSTSTT---VIPTTTKANS---------------IIEKDKEL 600
            ..|.|.|..|...|.:.....||...|.|   ||...:..:|               |:.|.:.|
Mouse   591 ILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEDILRKTEVL 655

  Fly   601 IR-ALGPALTREINIDDANNLIVFCNNTSDC---GV-TPR-TQTQPSHTTDSSPKILRTTVLTSI 659
            :| :..|.|.:  |:.| ..:.:..:.|.||   || .|: |..:.:|.....|.|:        
Mouse   656 VRDSEAPHLLQ--NLSD-YEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGII-------- 709

  Fly   660 RSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVY-------IGIVESSSSASPADISSTVIANERD 717
               :.|         ..:|.....||.....||       .|.|||::..       ||......
Mouse   710 ---LGP---------GNSTLFIERVTEEDEGVYRCRATNQKGAVESAAYL-------TVQGTSDK 755

  Fly   718 LNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSK 782
            .|:|     |:||....|     ||.:.:|:....||:..:.|             |.||.....
Mouse   756 SNLE-----LITLTCTCV-----AATLFWLLLTLFIRKLKRSS-------------SEVKTDYLS 797

  Fly   783 YQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFH 847
            ..:|.||..:|.|                   .:.:|..                     ||:: 
Mouse   798 IIMDPDEVPLDEQ-------------------CERLPYD---------------------ASKW- 821

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG-----ATRIVAVKTIR---ACSAQVSLKDEA 904
            :|.|..::|...||.|.||:|.:|.|      ||     ..|.||||.::   ..|...:|..|.
Mouse   822 EFARERLKLGKSLGRGAFGKVVQASA------FGIKKSPTCRTVAVKMLKEGATASEYKALMTEL 880

  Fly   905 NIMRKLGSHQNVVTLLGACV-ESEPHMLIMEYAMRGRLLSLLRAAR------------------- 949
            .|:..:|.|.|||.|||||. :..|.|:|:||...|.|.:.|::.|                   
Mouse   881 KILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKKES 945

  Fly   950 ----------------SATNILPASVPGGRSLA--------------PLSPRTLAGFALDIACGM 984
                            |::::..:|.|..||::              ||:...|..::..:|.||
Mouse   946 LEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGM 1010

  Fly   985 EYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFD 1049
            |:::.|:.:||||||||:||..|.:.||||||::.|:         .||.  |.:|..       
Mouse  1011 EFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI---------YKNP--DYVRRG------- 1057

  Fly  1050 FGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTE 1114
                                                  ||     .||::||||||:...:::|:
Mouse  1058 --------------------------------------DT-----RLPLKWMAPESIFDKVYSTK 1079

  Fly  1115 TDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMR 1178
            :|:|::|::||||.:||.:||..: ...:...|:.:|:|...|:.:..|.|.:|..||||:|..|
Mouse  1080 SDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKER 1144

  Fly  1179 PSFAQSRLEITRSLHKWVDDDSAASDYMDVSG--------------FSEDL-------------- 1215
            |.||:...::...|...|..|  ..||:.::.              |||||              
Mouse  1145 PRFAELVEKLGDLLQANVQQD--GKDYIPLNAILTRNSGFTYSTPTFSEDLFKDGFADPHFHSGS 1207

  Fly  1216 EHGVVYFN-------HRISEFE 1230
            ...|.|.|       .||..||
Mouse  1208 SDDVRYVNAFKFMSLERIKTFE 1229

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 111/387 (29%)
Flt1NP_034358.2 Ig_3 32..109 CDD:464046
IG_like 144..220 CDD:214653 5/16 (31%)
Ig 232..331 CDD:472250 24/130 (18%)
Ig strand B 249..253 CDD:409448 2/3 (67%)
Ig strand C 264..268 CDD:409448 0/3 (0%)
Ig strand E 295..299 CDD:409448 1/3 (33%)
Ig strand F 309..314 CDD:409448 1/17 (6%)
Ig strand G 322..325 CDD:409448 0/10 (0%)
Ig 334..425 CDD:472250 21/110 (19%)
Ig strand B 354..358 CDD:409353 0/3 (0%)
Ig strand C 367..371 CDD:409353 1/8 (13%)
Ig strand E 389..393 CDD:409353 0/3 (0%)
Ig strand F 403..408 CDD:409353 1/4 (25%)
Ig strand G 418..421 CDD:409353 0/5 (0%)
Ig 447..553 CDD:472250 26/159 (16%)
Ig strand B 451..455 CDD:409353 2/3 (67%)
Ig strand C 464..468 CDD:409353 3/3 (100%)
Ig strand E 515..520 CDD:409353 0/4 (0%)
Ig strand F 533..538 CDD:409353 1/4 (25%)
Ig strand G 546..549 CDD:409353 0/2 (0%)
IG_like 570..641 CDD:214653 16/89 (18%)
Ig strand B 574..578 CDD:409353 0/3 (0%)
Ig strand C 587..595 CDD:409353 2/7 (29%)
Ig strand E 620..624 CDD:409353 0/3 (0%)
Ig strand F 634..639 CDD:409353 0/4 (0%)
I-set 662..749 CDD:400151 24/116 (21%)
Ig strand B 680..683 CDD:409353 1/2 (50%)
Ig strand C 692..696 CDD:409353 1/3 (33%)
Ig strand E 715..719 CDD:409353 1/3 (33%)
Ig strand F 729..734 CDD:409353 2/4 (50%)
Protein Kinases, catalytic domain 820..1157 CDD:473864 114/404 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..983 5/35 (14%)
Blue background indicates that the domain is not in the aligned region.

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