Protein Alignment Tie and LOC1279581

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_061512028.1
• Gene: LOC1279581 / 1279581
• VectorBaseID: AGAMI1_009797
• Length: 872
• Species: Anopheles gambiae
• Alignment Length: 854
• Identity: 197/854 - (23%)
• Similarity: 298/854 - (34%)
• Gaps: 306/854 - (35%)

  Fly   509 EALPTDESTTTTSTTTTTEK-PSTTTSTSTTTTTPVPSTSK------RTTTNAPLSTTNTPTTTT 566
            |.||...:|:.....||.:. .|.|..|...|..|.....|      |..||..|:.....::..
Mosquito   153 EHLPALLNTSAIIKITTNQLIVSWTLGTFNKTEMPENVNLKAIYLGVRRGTNNDLAWGGQHSSMR 217

  Fly   567 SSTTPSTTTTSS-------TSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIV-- 622
            ....|..:.|.|       .|..:.....|.  |..:|.|  |...|.|   :::.||...:.
Mosquito   218 EIMLPVESNTHSFNINDFIGSKYIFVVQLKV--IDTRDCE--RTAQPIL---VSLPDAEKRLPNA 275

  Fly   623 ------FCNNTSDCG---------------------------VTPRTQTQPSHTTDSSPKI---- 650
                  .|.|.:.|.                           :.|.|..|||.|.....::
Mosquito   276 TGGSKGTCTNDTVCNCERLNRFPDFLLGCRHEGSEIIVTWRTLKPVTWRQPSSTDIVQLQLAIRS 340

  Fly   651 -LRTTVLTSIRSTVHPRPTSTST-------TTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADI 707
             |...:|.|:  :|.|..|:|.|       .||:|:....|.....|.....|:.:..  .|.::
Mosquito   341 ELTGAILCSV--SVDPMATNTHTFFVDEIVPTSSTSFVLTASFIDGNNYCERIIPTYK--IPPNL 401

  Fly   708 SSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQP 772
            :||.|            :..|..|||||..:.:.|.||::    ..:||.|
Mosquito   402 TSTSI------------LVPVICVLVAVITVTVLASILFI----YYKRRTK-------------- 436

  Fly   773 ISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQN----HQNHQHHQAMPMSQASQRDANHNR- 832
                                       .:...|:..    ..:..||..:.|.:        ||
Mosquito   437 ---------------------------FRWKANNWRGVYVRSSGDHHPQVAMEE--------NRL 466

  Fly   833 YGNNDDKTSLA---SEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRAC 894
            |.:.|...:.|   :::.:...|.:|:...:|:|.||:|:.|.|..|.| |...:|||:|.::.|
Mosquito   467 YIDMDILNARARGDADYLEVPHSCLRIGREIGKGAFGRVFMASAIKLPG-FSGPKIVAIKQLKKC 530

  Fly   895 SAQVSLK---DEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRA--------- 947
            |:.....   ||..:|:|:|.|.|:|.|||.|...||..:||||...|.||..||.
Mosquito   531 SSSDEFDEFLDEITMMKKVGKHPNIVALLGCCTIKEPLTMIMEYVGCGDLLEYLRKIRAKHLAKV 595

  Fly   948 -----------ARSATNILPASVPGGRSLAP---------------------------------- 967
                       |.|..|    :.||.....|
Mosquito   596 HQLDIGAQLENANSGLN----TAPGNNIFGPMVKYLDLLHTSSSNSDASYITQTDTTTRPSVTET 656

  Fly   968 --------------------------LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDH 1006
                                      |..:.|..||..||.|||::.|..|.||||||||:|:|.
Mosquito   657 TYTALSGTMGDEDNNSTIGSCSLEYVLDHKELHNFAKQIAFGMEHLEGLHITHRDLAARNILIDE 721

  Fly  1007 NGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGH 1071
            ....||.|||:|        |.....|..|
Mosquito   722 RKTLKISDFGLS--------RTGIYVNTRN----------------------------------- 743

  Fly  1072 CSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYS 1136
                     ||             :|:||::.|:::.::::.::|:||||||||||.|||..||.
Mosquito   744 ---------KK-------------VPLRWLSIEAMRDNLYSNKSDVWAFGIVLWEIGTLGGYPYP 786

  Fly  1137 QLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSL--HK--WVD 1197
            .::..|:...:.:|.|.:.|:....:.|:||.:||.::|:.||||.|    |::.|  ||  ::|
Mosquito   787 SVSNHELFAYLQEGKRLERPENCTVDVYDLMLQCWREDPNERPSFQQ----ISKHLQPHKKIYID 847

  Fly  1198 DDSAASDYM 1206
            .:.....|:
Mosquito   848 FNEIEPTYV 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	112/411 (27%)
LOC1279581	XP_061512028.1	None