Protein Alignment Tie and Pvr

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_061518287.1
• Gene: Pvr / 1275672
• VectorBaseID: AGAMI1_005611
• Length: 1480
• Species: Anopheles gambiae
• Alignment Length: 1215
• Identity: 236/1215 - (19%)
• Similarity: 384/1215 - (31%)
• Gaps: 459/1215 - (37%)

  Fly   255 MPSNGNSSV----VLKGSASLKAAAPAGDRD--TNEIL-----FSDESSHGLFVVAKEQNGTLN- 307
            :|.|.|.:|    |..||..|.....|..|:  :.|::     .:|:.::...|:  :.||..|
Mosquito   297 VPPNLNPAVRDARVRLGSLKLNPVKDAAHREIASRELIIERATMADDGTYRCEVM--DVNGHRNY 359

  Fly   308 -----HIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLPPI--------RPGGLT 359
                 |:.|.....||.:    :.|:: ||:....:.       ..|..||        .|..:|
Mosquito   360 HSFKLHVHDSGDDYVMLR----EENNL-DDINVRRNA-------NGKTAPIDIVIEYRSYPANIT 412

  Fly   360 IKAAEGDD-----DHPRVLEVSVAQSTT------PTITTTSTTPAPVSSTRPTASTR-------R 406
            ....:.||     .|....|::.:::..      |::|.|......|.:.....|.|       :
Mosquito   413 YYWLKDDDIEVMAGHHGKYELTHSETVVKLRINDPSVTDTGNYTLFVLAGNAEKSHRIGVYVYAK 477

  Fly   407 PLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRT-RYVGSGRPTAGLSDSIQDLKQTES 470
            |:..:|   ||:                  ..|...||.| |.:|..||..             |
Mosquito   478 PIVHME---SKF------------------VKPNEEVSFTCRSIGYPRPEI-------------S 508

  Fly   471 EVAKPVVRRVVQKVSPS--------SSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTE 527
            .:..|.:....:..|.|        ||:|.|.:..||  ..|.|.....|..:|..   .|.|.:
Mosquito   509 FMFLPCLEVPWRNCSASRTNKDKWDSSSPAISSESSA--RLTPGGKGETPIAKSRV---YTLTPK 568

  Fly   528 KPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTN-TPTTTTSSTTPSTTTTSSTSTTVIPTT---- 587
            :|......:|       :......|.|.|..:: :.:.......|....|.....|::.:.
Mosquito   569 QPGVVYCRAT-------NLEGSEITEADLLVSDLSDSVMLEKEQPKEAITVGDHVTIVCSALVYN 626

  Fly   588 -TKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSH--TTDSSPK 649
             ||..:.:..||||..:.|      :..|.:..|..:           :.:...:|  |....|.
Mosquito   627 YTKEITFVHNDKELQESDG------VRHDYSAELYAW-----------QARLDIAHVATEHEGPI 674

  Fly   650 ILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEV--------------YIGI----- 695
            ..|...:|   ..|..|......   ....||..|:..|||.              .:|.
Mosquito   675 YCRAKTMT---GAVESRAFHVEV---LEPVAPMLVSGKSNESLSVDLHDPLKLECDIVGTPDPKI 733

  Fly   696 --------VESSSSASPADISSTVIANE----RDLNM-EMRRMN--------------------- 726
                    |....:::...::.|.:..|    .||.| |.|..|
Mosquito   734 VWLKDGEPVRPDENSNRVQLTKTTLIFEYLKTDDLGMFECRAENKMGTIEKYWKVDVRTAVVRKS 798

  Fly   727 -----LVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVD 786
                 |..|:::.||::        ||..|..|::.:...:.:..|.:.:        :....|.
Mosquito   799 VIYIILSLLLVLIVGIV--------LVSMFYCRKKKEVKAMKEAGIVNFE--------EGNLGVY 847

  Fly   787 DDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFER 851
            :.|..:|.|                                         .|.....||: :|.:
Mosquito   848 NPELALDEQ-----------------------------------------ADLLPYNSEY-EFPK 870

  Fly   852 SNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS---AQVSLKDEANIMRKLGSH 913
            ..::|...||.|.||.|.||.|..:..:...| .||||.::..:   ...:|..|..||..||.|
Mosquito   871 ERLKLGKQLGTGAFGVVMKATAQRIMVNEDET-TVAVKMVKKQTDNEVMRALVSELKIMVHLGQH 934

  Fly   914 QNVVTLLGAC---VESEPHMLIMEYAMRGRLLSLLRAAR-------------------------- 949
            .|||.||||.   :.....|:|:||...|.:.:.|...|
Mosquito   935 LNVVNLLGAVTKNIAKRELMVIVEYCRFGNVQNFLLKHRPHFIDQINQETGEIDSSIDKNQLRWS 999

  Fly   950 ------------------SATNI------------------------------------------ 954
                              |..|:
Mosquito  1000 KCGYQYNSQGLKYVNLSFSTNNVNHHPLQHPTAFYHNNHIDSGSTQYVDPKKHLNSKGYVRHSGL 1064

  Fly   955 --------------------------LPASVPGGRS---------LAPLSPRTLAGFALDIACGM 984
                                      :.::.|..||         ...::...|..:|..|||||
Mosquito  1065 QNMGMVDSCNTEVTAMTSVEVEDLNSVNSNEPLWRSNYGMDYKGPARTVNTTDLVCWASQIACGM 1129

  Fly   985 EYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFD 1049
            ||:|.|:::|.||||||:||..:.:.||||||:                 |..:.:.:.:|.|
Mosquito  1130 EYLASRKVLHGDLAARNILLCDDNVVKICDFGL-----------------ARSMYKSDNYKKK-- 1175

  Fly  1050 FGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTE 1114
                                         ||.             .||.:|:|.|.:..::|:|.
Mosquito  1176 -----------------------------GEA-------------PLPFKWLALECIGDNVFSTY 1198

  Fly  1115 TDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMR 1178
            :|:||:||||||:.:||..||..: ..:|:..::..|.|.|.|:.|..:.|::|..||:.:|..|
Mosquito  1199 SDVWAYGIVLWELFSLGKVPYPGMEANQELYNKLRDGYRMDKPQYSNQDIYDIMLNCWNVKPDSR 1263

  Fly  1179 PSFAQSRLEITRSLHKWVDDDSAASDYMDVSG-----FSEDLEHG 1218
            |||...:......|     .|.....|::::.     .:|.:|.|
Mosquito  1264 PSFKDLKSRFNAML-----PDDMRDHYLELNEPYLQMNAEKMERG 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	107/456 (23%)
Pvr	XP_061518287.1	None