Protein Alignment Tie and LOC1273778

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_061505105.1
• Gene: LOC1273778 / 1273778
• VectorBaseID: AGAMI1_002663
• Length: 2368
• Species: Anopheles gambiae
• Alignment Length: 1124
• Identity: 263/1124 - (23%)
• Similarity: 400/1124 - (35%)
• Gaps: 325/1124 - (28%)

  Fly   221 SDPRSVCIRNCTKNFTRRTT---ASCMRQCANFTRMAMPSNGN-SSVVLKGSASLK----AAAPA 277
            |||.::.|....|...:.|.   :..:.:| ||...|...||. ..|..|.:.||:    ....|
Mosquito    35 SDPDTIRINLGNKKLVKETVPLYSKLIIKC-NFDSPAWYKNGKLIPVDHKRAKSLRFERVRKTDA 98

  Fly   278 GDRDTNEILFSDESSHGLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKP 342
            |...... .|.:.|:..|.|.::|   |..:.:||...|.:                 |...|..
Mosquito    99 GYYSCGS-EFHEWSNLTLSVFSQE---TDQYQSDGAGMANL-----------------ERKSLHS 142

  Fly   343 YVYFGAKLPPIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTT----------PAP-VS 396
            .....|...||    |..:..||.   ||:|........:|.:......          ||| ||
Mosquito   143 SSVAAAAATPI----LDNELKEGP---PRILGTRDEPYPSPVVRGVGEAYRLKCDAVGQPAPHVS 200

  Fly   397 STRPTASTRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDS 461
            ..:..|..|         .:.||..:..:.|:||.|             ..||.:.....|..::
Mosquito   201 WLKDGAEYR---------DNSYKSTIVFKQLLPTDA-------------GTYVCNVCNVYGCVNA 243

  Fly   462 IQDLKQTESEVAKP--VVRRVVQKVSPSSSTPLIITVLSAEEETTV-----------GQTEALP- 512
            ...|:..||...:|  :....::..|.....|       |.::|.|           |.||..|
Mosquito   244 TTVLEVVESGEHEPAYIQHNTMESHSQLQGDP-------ATQDTQVMMRALGRYYPAGATEKRPQ 301

  Fly   513 -------------------TDESTTTTSTTTTTEKPSTTTSTSTTTT----TPVPSTSKRTTTNA 554
                               .:|......|..|....|.||..|....    ||.|.       .|
Mosquito   302 HHTYQPEDADMDEDDDEDGEEEEEEEGPTNGTGVHGSDTTEDSAGAVNGSGTPPPD-------RA 359

  Fly   555 PLSTTNTPTTTTSSTTPSTTTTSSTSTTVIP----TTTKANSIIEKDKELIRALGPALTRE--IN 613
            |:.|.....|...|................|    |.||....||:....::.:..|:..|  :.
Mosquito   360 PIFTKKDQMTKIVSKPSGNMVRLRCPADGYPKPNITWTKDGRKIERAMGQVKKVNWAIVLEDLVP 424

  Fly   614 IDDANNLIVFCNN------TSDCGVTPRTQTQPSHTTDSSPK----ILRTTVLTS--IRSTVHPR 666
            .|..:.....||.      |:...|..|...:| |.|: .||    ::.|||:.|  |.|.:.|.
Mosquito   425 QDSGSYTCAVCNQVGCINFTTKLEVKDRFPARP-HITE-RPKNVTALVNTTVIFSCPILSDLEPH 487

  Fly   667 --------------------------PTSTSTTTSTTTT----------APPAVTAPSNEVYIGI 695
                                      |.:....|....|          |..::.|.:...|:.:
Mosquito   488 IEWVKLGLVDLENMSIPENVTKLKRDPDNPEVLTLENVTHADEGWYTCIAANSLGATNESAYLQV 552

  Fly   696 V-----ESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRR 755
            :     :.:.:|.|....||:|..             :|:.|.|  ...:.|:|:.:|...:.|.
Mosquito   553 LDELPPDDTPTAHPVRTHSTLIMG-------------MTIFLCA--CFTVLAVIVIIVCKKLKRE 602

  Fly   756 RAKQSEVFDV------CITDQQPI--SPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNH 812
            :.|...:..|      .|..:||:  |.:..:....|
Mosquito   603 KMKHRAMEHVNQWTKKVIVLKQPVVESSIPGMSEALQ---------------------------- 639

  Fly   813 QHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFH-------DFERSNIRLKSLLGEGNFGQVWK 870
                 ||:.:..::.:...:.||.|  .::.||:.       :|.|:.:.|...||||.||:|..
Mosquito   640 -----MPIVRIEKQRSTLVQSGNCD--PTMISEYEFPIDLNWEFPRNKLHLGKSLGEGMFGKVVM 697

  Fly   871 AEADDL-SGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHML 931
            |||..| .||  .:.:||||.::.......:||   |..:|:.:|.|.|::.|||.|.:..|..:
Mosquito   698 AEAHGLVKGH--PSTVVAVKMLKEGHTDADVKDLVCEMEVMKMIGKHVNIINLLGCCCKDGPLYV 760

  Fly   932 IMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRD 996
            |:|||..|.|.:.||:.|..:|.   .....:....|:.:.|..||..||.|||::|.||.:|||
Mosquito   761 IVEYAPHGNLKNFLRSHRFGSNY---EATNEKEKKILTQKELISFAYQIARGMEHLASRRCIHRD 822

  Fly   997 LAARNVLLDHNGMCKICDFGMSIDL-DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQ 1060
            |||||:|:..|.:.||.|||::.|: |.|..||
Mosquito   823 LAARNILVSDNYVMKIADFGLARDIHDQEYYRK-------------------------------- 855

  Fly  1061 HTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLW 1125
                                       .|.||   |||||||||||:...:.:::|:|:||::||
Mosquito   856 ---------------------------TTTGK---LPIRWMAPESLEEKFYDSQSDVWSFGVLLW 890

  Fly  1126 EIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEIT 1189
            ||.|||..||..: |...::..:.:|.|.:.|.....|.|..|..|||..|..||:|:    ||.
Mosquito   891 EIMTLGGNPYPSIPTWDNLLEHLKKGKRMEKPPLCSIEIYLFMRECWHYRPEERPTFS----EIV 951

  Fly  1190 RSLHKWVDDDSAASDYMDV 1208
            :.|.:.|...| ..:|:|:
Mosquito   952 QHLDRLVSITS-NEEYLDL 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	113/334 (34%)
LOC1273778	XP_061505105.1	None