Protein Alignment Tie and epha6

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_031752444.1
• Gene: epha6 / 100495504
• XenbaseID: XB-GENE-6032564
• Length: 1008
• Species: Xenopus tropicalis
• Alignment Length: 867
• Identity: 183/867 - (21%)
• Similarity: 291/867 - (33%)
• Gaps: 281/867 - (32%)

  Fly   424 ERGLVPTAAPPPA----APPAPP------VSRTR-YVGSGRP--TAGLSDSIQDLKQTESEVAKP 475
            |:|.......||:    .||:.|      ::.|. |:....|  |.|..|.:.::
 Frog   313 EKGFYRAEKDPPSMACTKPPSAPRNANFNMNETALYLEWSPPIDTGGRKDVVYNV---------- 367

  Fly   476 VVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTT--------TEKPSTT 532
                :.:|..||..            |...|....:|........|.|..        |.....|
 Frog   368 ----LCKKCDPSQC------------ELCGGGIRYVPAHSGLQNASVTVLDFLSHVNYTFDIEAT 416

  Fly   533 TSTSTTTTTPVPSTSKRTTTN--AP--LSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSI 593
            ...|..:..|.|.||...||:  ||  :........:.:|...|..........::....|   .
 Frog   417 NGVSELSFLPKPYTSIMITTDQEAPSLIGMVRKDWASQNSIALSWQEPDYPKGLIVDYEIK---Y 478

  Fly   594 IEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTS 658
            .|||...|   .||....:.:::                  ..|...|.|...:|.::.|.:..:
 Frog   479 YEKDYPRI---APAFWHYLRVEE------------------HEQLSYSSTRSKAPSVIITGLKPA 522

  Fly   659 IRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMR 723
            .:...|.|         ..|||..:..:...|...|...|..:|....|
 Frog   523 TKYIFHIR---------VRTTAGYSAYSHKFEFETGDETSDLAAEQGQI---------------- 562

  Fly   724 RMNLVTLVLVAVGVIPLAAI--ILYLVR---NFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKY 783
                :.:...|||...|..|  :.:|:.   .:.|:.:.|..|
 Frog   563 ----LVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEE---------------------- 601

  Fly   784 QVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHD 848
                                :...|.||  .|...|         ....|.:.|.....:...|:
 Frog   602 --------------------KRRANLQN--GHLQFP---------GVKTYIDPDTYEDPSLAVHE 635

  Fly   849 FER----SNIRLKSLLGEGNFGQVWKAEADDLSGHFGATR----IVAVKTIRACSAQVSLKD--- 902
            |.:    |.||::.::|.|.||:|       .||......    .||:||::........||
 Frog   636 FAKEIDPSRIRIERVIGAGEFGEV-------CSGRLKTPAKKEIPVAIKTLKGGYVDRQRKDFLR 693

  Fly   903 EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAP 967
            ||:||.:. .|.|::.|.|...:|.|.|:::||...|.|.|.||.......::
 Frog   694 EASIMGQF-DHPNIIRLEGVVTKSRPVMIVVEYMENGSLDSFLRKHDGQFTVI------------ 745

  Fly   968 LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEK 1032
                .|.|....||.||:|::....|||||||||:|::.|.:||:.|||:|..|       |.:.
 Frog   746 ----QLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVL-------EDDP 799

  Fly  1033 NAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALP 1097
            :||                                                   :.|.|.:  :|
 Frog   800 DAA---------------------------------------------------YTTTGGK--IP 811

  Fly  1098 IRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHE 1162
            |||.|||::.:..|::.:|.|::|||:||:.:.|..||.:::.::||..:.:|.|...|......
 Frog   812 IRWTAPEAIAFRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPVS 876

  Fly  1163 FYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSA-----------------ASDY---MD 1207
            .:.||..||.|:.::||.|:    :|...|.|.:.:.||                 |.:|   :.
 Frog   877 LHQLMLHCWQKDRNIRPKFS----DIVGFLDKLIRNPSALHILVEDILGMPESPGDAPEYHFVVT 937

  Fly  1208 VSGFSEDLEHGVVYFNHRISEF 1229
            ||.:.|.::.|....|...|.|
 Frog   938 VSEWLESIKMGQYAHNFMASGF 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	94/335 (28%)
epha6	XP_031752444.1	EphR_LBD_A6	34..206	CDD:198452
		FN3	333..421	CDD:473895	17/113 (15%)
		FN3	441..548	CDD:238020	21/139 (15%)
		EphA2_TM	565..642	CDD:464211	18/129 (14%)
		PTKc_EphR_A	640..906	CDD:270651	98/353 (28%)
		SAM_EPH-A6	933..996	CDD:188946	7/27 (26%)