Protein Alignment Tie and ntrk1

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_002939035.2
• Gene: ntrk1 / 100489637
• XenbaseID: XB-GENE-923001
• Length: 808
• Species: Xenopus tropicalis
• Alignment Length: 738
• Identity: 184/738 - (24%)
• Similarity: 283/738 - (38%)
• Gaps: 166/738 - (22%)

  Fly   494 ITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPV----PSTSKRTTTNA 554
            :|||.....|.|...:..||..:|.......:..:...:..:.|....|:    |..:||.
 Frog   212 LTVLEGANLTLVCNVDGQPTPTATWIVPEMDSYTEIGQSNGSETEIFLPLFNISPGFNKRN---- 272

  Fly   555 PLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKE--LIRALGPALTREINIDDA 617
                                           .|.:|.:::...:|  .|..|.||:.  :.:::|
 Frog   273 -------------------------------VTCRAENMVGPSEEHVQINVLFPAMV--VALEEA 304

  Fly   618 NNLIVFC-NNTSDCGVTPRTQTQ-PSHTTDSSPKILRTTVLTSIRST-VH-----PRPTSTSTTT 674
            .....|| ..|.|....|..:.| ..|..:.:..|...||..|..|| :|     .:||..:...
 Frog   305 IPQHHFCFPYTVDGNPKPEIRWQFNGHNLEMNDYIYLKTVEESENSTAIHGCLYLNKPTHVNNGN 369

  Fly   675 STTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLN------MEMRRMNLVTLVLV 733
            .|........:| |..||...:::..|.:|.:.....::.|...|      :|....|... |.|
 Frog   370 YTILVWNMLGSA-SETVYSKFMDNPFSFNPEEPIPVSLSPEGGGNSTYTTTVETVEENTFG-VSV 432

  Fly   734 AVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQ 798
            |||:...|.:.|.|:  .:...:..:...|.:               ::..|...||::....|
 Frog   433 AVGLAVFACLFLLLI--LIALNKCGRHSKFGI---------------NRAAVLAQEDDLAMSLH- 479

  Fly   799 HMQHHQNHQNHQNHQHHQAMPMSQASQR-DANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGE 862
                         ..:....|::.|..: |.....:..|......|...| .:|.:|.||..|||
 Frog   480 -------------FMNFGTSPLTSAEGKLDGMKPNFIENPQYFCDACVQH-IKRRDIVLKWELGE 530

  Fly   863 GNFGQVWKAEADDLSGHFGATRIVAVKTIRAC--SAQVSLKDEANIMRKLGSHQNVVTLLGACVE 925
            |.||:|:.||..:|:.....| :||||.::..  :|:...:.||.::..| .|:::|...|.|.:
 Frog   531 GAFGKVFLAEFYNLTPENEKT-LVAVKALKEATENARQDFQREAELLTVL-QHEHIVKFYGVCTD 593

  Fly   926 SEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGR 990
            .||.:::.||...|.|...||:......||...  .|:....|:...:...|..||.||.|:|..
 Frog   594 GEPLIMVFEYMKHGDLNRFLRSHGPDAKILDNG--NGQPYGQLNLTQMLQIASQIASGMVYLASL 656

  Fly   991 RIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYI 1055
            ..||||||.||.|:.:|.:.||.|||||.|:                                |.
 Frog   657 HFVHRDLATRNCLVGNNLVVKIGDFGMSRDI--------------------------------YS 689

  Fly  1056 LQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAF 1120
            ..:::                             :|.|..||||||.|||:.|..||||:|||:|
 Frog   690 TDYYR-----------------------------VGGRTMLPIRWMPPESILYRKFTTESDIWSF 725

  Fly  1121 GIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSR 1185
            |:|||||.|.|..|:.||:..|.|..:.||.:.:.|:....|.||:|..||.:||       |.|
 Frog   726 GVVLWEIFTYGKQPWYQLSNTEAIECITQGRQLERPRTCPTEVYNIMQGCWQREP-------QQR 783

  Fly  1186 LEITRSLHKWVDDDSAASDYMDV 1208
            |.|....:|......|...|:|:
 Frog   784 LNIKEIHNKLQALVKAPPVYLDI 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	108/330 (33%)
ntrk1	XP_002939035.2	LRR_8	97..156	CDD:404697
		leucine-rich repeat	99..122	CDD:275378
		leucine-rich repeat	123..145	CDD:275378
		LRRCT_2	157..201	CDD:465313
		Ig	211..292	CDD:472250	17/114 (15%)
		Ig strand B	220..224	CDD:409353	1/3 (33%)
		Ig strand C	233..237	CDD:409353	1/3 (33%)
		Ig strand E	257..261	CDD:409353	0/3 (0%)
		Ig strand F	272..277	CDD:409353	1/39 (3%)
		Ig strand G	285..288	CDD:409353	1/2 (50%)
		Ig	295..390	CDD:472250	24/97 (25%)
		Ig strand B	310..314	CDD:409353	2/3 (67%)
		Ig strand C	323..327	CDD:409353	0/3 (0%)
		Ig strand E	355..359	CDD:409353	0/3 (0%)
		Ig strand F	369..374	CDD:409353	1/4 (25%)
		Ig strand G	382..385	CDD:409353	1/2 (50%)
		PTKc_TrkA	516..795	CDD:270674	115/351 (33%)