DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta1 and Chrne

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_017452660.1	Gene:	Chrne / 29422	RGDID:	2353	Length:	547	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	167/502 - (33%)
Similarity:	266/502 - (52%)	Gaps:	51/502 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SASEDEE-RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYD 86
            |..::|| .|...||..|:...|||:.....|.:...:....||::|||.:.:.::||:.:.|.|
  Rat    71 SQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQD 135

  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151
            |:|.:.:.|:.|:.:||:|.:.||.|:|||.||.||.:.|.|..|||:|..|.|.|:|||||:|:
  Rat   136 YRLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRST 200

  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSL---------ALYNNKNFVDLSDYWKSGTWDIIEV 207
            |.::|||||||.|.|.:.|.|.|:|.::|..         |:  ||..:|.:.:.::|.|.|...
  Rat   201 CAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAI--NKIDIDTAAFTENGEWAIDYC 263

  Fly   208 PAYLNVYEGDSNH-PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-GEKVTL 270
            |..:..|||.|.. |.|||:.:.:|||||.|||.:|:|:|.||||.|.:|.::|||:| |:|.|:
  Rat   264 PGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTV 328

  Fly   271 GISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPM 335
            .|::||:..|||.|:::.:|.|||.:||:.:||:|..::.|:.::..||::|.:.|.|.||....
  Rat   329 SINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSP 393

  Fly   336 YIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEV 400
            .:|.|.|..||..|.:..|        .|.||.:.||....|.|......:.|.    |:.:.|:
  Rat   394 RLRQILLELLPRLLGLSPP--------PEDPGAASPARRASSVGILLRAEELIL----KKPRSEL 446

  Fly   401 MELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLY 465
            :.....|.           .|.......|:..|.:      :||.....:||.|:||..|:::..
  Rat   447 VFEGQRHR-----------HGTWTAAALCQNLSAA------APEVRCCVDAVNFVAESTRDQEAT 494

  Fly   466 IQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM--------DAPH 504
            .:...||..:...:|.:..:...::.:.|:..|.:        |.|:
  Rat   495 GEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	165/488 (34%)
		Neur_chan_LBD	28..236	CDD:280998	86/218 (39%)
		Neur_chan_memb	243..498	CDD:280999	72/255 (28%)
Chrne	XP_017452660.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810