Protein Alignment nAChRbeta1 and Chrne

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_017452660.1
• Gene: Chrne / 29422
• RGDID: 2353
• Length: 547
• Species: Rattus norvegicus
• Alignment Length: 502
• Identity: 167/502 - (33%)
• Similarity: 266/502 - (52%)
• Gaps: 51/502 - (10%)

  Fly    23 SASEDEE-RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYD 86
            |..::|| .|...||..|:...|||:.....|.:...:....||::|||.:.:.::||:.:.|.|
  Rat    71 SQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQD 135

  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151
            |:|.:.:.|:.|:.:||:|.:.||.|:|||.||.||.:.|.|..|||:|..|.|.|:|||||:|:
  Rat   136 YRLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRST 200

  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSL---------ALYNNKNFVDLSDYWKSGTWDIIEV 207
            |.::|||||||.|.|.:.|.|.|:|.::|..         |:  ||..:|.:.:.::|.|.|...
  Rat   201 CAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAI--NKIDIDTAAFTENGEWAIDYC 263

  Fly   208 PAYLNVYEGDSNH-PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-GEKVTL 270
            |..:..|||.|.. |.|||:.:.:|||||.|||.:|:|:|.||||.|.:|.::|||:| |:|.|:
  Rat   264 PGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTV 328

  Fly   271 GISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPM 335
            .|::||:..|||.|:::.:|.|||.:||:.:||:|..::.|:.::..||::|.:.|.|.||....
  Rat   329 SINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSP 393

  Fly   336 YIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEV 400
            .:|.|.|..||..|.:..|        .|.||.:.||....|.|......:.|.    |:.:.|:
  Rat   394 RLRQILLELLPRLLGLSPP--------PEDPGAASPARRASSVGILLRAEELIL----KKPRSEL 446

  Fly   401 MELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLY 465
            :.....|.           .|.......|:..|.:      :||.....:||.|:||..|:::..
  Rat   447 VFEGQRHR-----------HGTWTAAALCQNLSAA------APEVRCCVDAVNFVAESTRDQEAT 494

  Fly   466 IQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM--------DAPH 504
            .:...||..:...:|.:..:...::.:.|:..|.:        |.|:
  Rat   495 GEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	165/488 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	86/219 (39%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
Chrne	XP_017452660.1	LGIC_ECD_nAChR_E	102..292	CDD:349831	76/191 (40%)
		Cys-loop	201..215	CDD:349831	9/13 (69%)
		Neur_chan_memb	300..528	CDD:460753	72/256 (28%)