Protein Alignment: nAChRbeta1 and Chrne

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_017452660.1
• Gene: Chrne
• RGDID: 2353
• Length: 547
• Species: Rattus norvegicus
• Alignment Length: 502
• Identity: 167/503 (33%)
• Similarity: 266/503 (53%)
• Gaps: 51/503 (10%)

  Fly    23 SASEDEE-RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYD 86
            |..::|| .|...||..|:...|||:.....|.:...:....||::|||.:.:.::||:.:.|.|
  Rat    71 SQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQD 135

  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151
            |:|.:.:.|:.|:.:||:|.:.||.|:|||.||.||.:.|.|..|||:|..|.|.|:|||||:|:
  Rat   136 YRLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRST 200

  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSL---------ALYNNKNFVDLSDYWKSGTWDIIEV 207
            |.::|||||||.|.|.:.|.|.|:|.::|..         |:  ||..:|.:.:.::|.|.|...
  Rat   201 CAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAI--NKIDIDTAAFTENGEWAIDYC 263

  Fly   208 PAYLNVYEGDSNH-PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-GEKVTL 270
            |..:..|||.|.. |.|||:.:.:|||||.|||.:|:|:|.||||.|.:|.::|||:| |:|.|:
  Rat   264 PGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTV 328

  Fly   271 GISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPM 335
            .|::||:..|||.|:::.:|.|||.:||:.:||:|..::.|:.::..||::|.:.|.|.||....
  Rat   329 SINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSP 393

  Fly   336 YIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEV 400
            .:|.|.|..||..|.:..|        .|.||.:.||....|.|......:.|.    |:.:.|:
  Rat   394 RLRQILLELLPRLLGLSPP--------PEDPGAASPARRASSVGILLRAEELIL----KKPRSEL 446

  Fly   401 MELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLY 465
            :.....|.           .|.......|:..|.:      :||.....:||.|:||..|:::..
  Rat   447 VFEGQRHR-----------HGTWTAAALCQNLSAA------APEVRCCVDAVNFVAESTRDQEAT 494

  Fly   466 IQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM--------DAPH 504
            .:...||..:...:|.:..:...::.:.|:..|.:        |.|:
  Rat   495 GEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	165/489 (34%)
		Neur_chan_LBD	28..236	CDD:280998	87/219 (40%)
		Neur_chan_memb	243..498	CDD:280999	72/256 (28%)
Chrne	XP_017452660.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR18945
Phylome	1	0.910		0.803	Consistency score
TreeFam	0	0.000	Not matched by this tool.
	3	2.910