DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIEbeta and Gtf2e2

DIOPT Version :9

Sequence 1:	NP_523923.1	Gene:	TfIIEbeta / 38527	FlyBaseID:	FBgn0015829	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_001100788.2	Gene:	Gtf2e2 / 306516	RGDID:	1310134	Length:	291	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	163/297 - (54%)
Similarity:	209/297 - (70%)	Gaps:	23/297 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPALLREREAFKKRAMATPTVEKKSKPDRPAPPPPSDDSRRKM----------RPPNAPRLDAT 55
            |||:|||:||.|||||::||.|||::.|..    .||..|::|.          ...|:...:.:
  Rat     1 MDPSLLRDRELFKKRALSTPVVEKRAVPSE----SPSSSSKKKKAKVEHGGSSGSKQNSDHNNGS 61

  Fly    56 -TYKTMSGSSQYRFGVLAKIVKFMRTRHQDGDDHPLTIDEILDETNQLDIGQSVKNWLASEALHN 119
             ..|.:||||.|:||||||||.:|:||||.||.||||::||||||..||||...|.||.:|||.|
  Rat    62 FNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVN 126

  Fly   120 NPKVEASPCGTKFSFKPVYKIKDGKTLMRLLKQHDLKGLGGILLDDVQESLPHCEKVLKNRSAEI 184
            |||:|.  ...|::|||.|.:||.|.|:|||..||.:|||||||:|::|.||:.:|.:|....:|
  Rat   127 NPKIEV--VDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQI 189

  Fly   185 LFVVRPIDKKKILFYNDRTANFSVDDEFQKLWRSATVDAMDDAKIDEYLEKQGIRSMQDHGLKK- 248
            |||.|| |||||||:||::..||||:||||||||.|||:||:.||:|||::|||.|||:.|.||
  Rat   190 LFVSRP-DKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKV 253

  Fly   249 -AIPKRKK-AANKKRQFKKPRDNEHLADVLEVYEDNT 283
             :|.:||| |:.|||:||  ..|||||.||:.|.|.|
  Rat   254 ASIQRRKKPASQKKRRFK--THNEHLAGVLKDYSDIT 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIEbeta	NP_523923.1	TFIIE_beta_winged_helix	61..141	CDD:153423	50/79 (63%)
Gtf2e2	NP_001100788.2	TFIIE_beta_winged_helix	68..146	CDD:153423	50/79 (63%)
Gtf2e2	NP_001100788.2	TFA2_Winged_2	146..204	CDD:407955	35/58 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341677
Domainoid	1	1.000	96	1.000	Domainoid score	I7168
eggNOG	1	0.900	-	-		E1_COG5174
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37573
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2657
OMA	1	1.010	-	-		QHG48945
OrthoDB	1	1.010	-	-		D1160863at2759
OrthoFinder	1	1.000	-	-		FOG0007303
OrthoInspector	1	1.000	-	-		oto96137
orthoMCL	1	0.900	-	-		OOG6_103945
Panther	1	1.100	-	-	LDO	PTHR12716
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4699
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770