DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ero1L and ero1a

DIOPT Version :9

Sequence 1:	NP_647865.2	Gene:	Ero1L / 38500	FlyBaseID:	FBgn0261274	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001016058.1	Gene:	ero1a / 548812	XenbaseID:	XB-GENE-978124	Length:	474	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	226/489 - (46%)
Similarity:	309/489 - (63%)	Gaps:	52/489 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AAVVLVLLLLWTDTTGGYFAAIDETETSKNCFCELEGSINDCSCDVDTVDHFNNMKIYPRLQSLL 78
            :.:||..||||     |..:..:::..::.|||::.|.::||:|||:|:|||||..::|:||.|:
Frog    15 SVLVLCSLLLW-----GSNSQQEQSSAAQRCFCQVTGYLDDCTCDVETIDHFNNYGLFPKLQQLV 74

  Fly    79 VKNFFRFYKVNLRQECPFWPDDSRCAMRFCQVENCEEQAIPQGIKDKGEHKEKAAFKYTREAQVG 143
            ..::||:||.||::.||||.|:|.|.::.|.|:.|....:| |:|..|       ||||.||...
Frog    75 ASDYFRYYKANLKKPCPFWEDNSHCGVKDCAVKPCPTDEVP-GLKPPG-------FKYTEEANRA 131

  Fly   144 GSACSDGEDFDSSLGFLDTSISDQAHREFELWAKHDEAEEDFCIVDDHEE-GSQYVDLLLNPERY 207
            .....|.|. :..|..:|.|:|.:|......|.:||::.::||.:||.|. .::|||||.|||||
Frog   132 HEEIDDCEK-EKRLSAVDESLSVEAQEAMLKWNRHDDSADNFCELDDEESPDAEYVDLLKNPERY 195

  Fly   208 TGYKGESAHRIWKSIYLENCF---------------GGNNETANKFSNYVPHLDLRNVCLEQRAF 257
            |||||....|||.|||.||||               .|.|| ...|.|:     |..:|:|:|||
Frog   196 TGYKGADTWRIWNSIYEENCFKPKAVQRPLNPLTSTRGENE-GKVFYNW-----LDGLCVEKRAF 254

  Fly   258 YRIISGLHSSINIHLCSKYLLSESKDFLDPQGIWGPNVKEFKRRFSPETTSGEGPHWLRNLYFIY 322
            ||:|||||:|||||||:.|||.::  ::|.  |||.|..||::||....|.||||..|:||||||
Frog   255 YRLISGLHASINIHLCANYLLKDT--WMDK--IWGHNTAEFQKRFDATLTQGEGPKRLKNLYFIY 315

  Fly   323 LIELRALAKAAPYLRREDY--YTGIAEEDDEVKLAINDMLSVIENFQSHFDENALFS-NGIASIK 384
            ||||||::|..|:..|..:  |||...:|.|.|..:.|:|....:|..|||||:||| :...:.|
Frog   316 LIELRAISKVLPFFERSSFLLYTGNETKDTETKKLLLDVLLDARDFPLHFDENSLFSGDKKEAAK 380

  Fly   385 FKHDYKEKFRNISRIMSCVGCDKCKLWGKLQTQGLGTALKILYSEK-LNLATESGLWDKPHIEAD 448
            .|.|:::.|||||:||.||||.||:|||||||||||||||||:||: :...:||   ::|
Frog   381 LKEDFRQHFRNISKIMDCVGCFKCRLWGKLQTQGLGTALKILFSERQIENLSES---NQP----- 437

  Fly   449 PIFRLSRTEIVALFNAFGRLSNSIYEMENFRCVL 482
            ..|.|:|.|||||||||.|:|.|:.|:||||.:|
Frog   438 SEFHLTRQEIVALFNAFARISTSVKELENFRTLL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ero1L	NP_647865.2	ERO1	69..473	CDD:282050	198/423 (47%)
ero1a	NP_001016058.1	ERO1	66..462	CDD:282050	198/422 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	363	1.000	Domainoid score	I941
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1796
OMA	1	1.010	-	-		QHG54085
OrthoDB	1	1.010	-	-		D1181226at2759
OrthoFinder	1	1.000	-	-		FOG0001495
OrthoInspector	1	1.000	-	-		otm48061
Panther	1	1.100	-	-	O	PTHR12613
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R413
SonicParanoid	1	1.000	-	-		X1065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110