Protein Alignment CG11594 and GK3

DIOPT Version :10

• Sequence 1: NP_647848.2
• Gene: CG11594 / 38473
• FlyBaseID: FBgn0035484
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_001382882.1
• Gene: GK3 / 2713
• HGNCID: 4292
• Length: 553
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 142/584 - (24%)
• Similarity: 220/584 - (37%)
• Gaps: 149/584 - (25%)

  Fly     4 GPFFVGVDVGTGSARAALVACDGRVLE----QAVQTIQTWNPEPGYYNQSSDNIWQSICQVVKKV 64
            ||....||.||.|.|  .:..:.|..|    ..|:..|.: |..|:..|....|..|:.:.::|.
Human    10 GPLVGAVDQGTSSTR--FLVFNSRTAELLSHHQVEIKQEF-PREGWVEQDPKEILHSVYECIEKT 71

  Fly    65 ---IG--GVDKSKVKGIGFDATCSLVVLGPQGSPLTVSK-SGEAEQNIILWMDHRAEQETQEINA 123
               :|  .:..|.:|.||        |...:.:.:...| :||...|.::|:|.|. |.|.|
Human    72 CEKLGQLNIGISNIKAIG--------VSNQRETTVVWDKITGEPLYNAVVWLDLRT-QSTVE--- 124

  Fly   124 FKHSLLKYVGGQ-----------VSLEMEVPKLLWLKRNLSQT----------FGNIWRVFDLPD 167
               ||.|.:.|.           :|......||.||..|:.:.          ||.|      ..
Human   125 ---SLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTI------DS 180

  Fly   168 FLTWRAT-GVDTRSLCSVVCKWNYDAANGS-----------WNKEFLKQADLEELTQNNFEKLGS 220
            :|.|..| ||:....|:       |..|.|           |:|:..:           |..:..
Human   181 WLIWSLTGGVNGGVHCT-------DVTNASRTMLFNIHSLEWDKQLCE-----------FFGIPM 227

  Fly   221 DVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGALGMFGC----RSKESKGADDVQGKM 281
            ::.|..|:..:......||.|   .|..:|..|.|..|..:|.. |    ::|.:.|.    |..
Human   228 EILPHVRSSSEIYGLMKAGAL---EGVPISGCLGDQSAALVGQM-CFQIGQAKNTYGT----GCF 284

  Fly   282 ALIAGTSTC----HMSITRKACFAQGVWGPYQDAIIPGYFLNEGGQSIAGHLL----DH--VLKS 336
            .|......|    |..:|..| :..|     :|.  |.|:..||..:|||.::    |:  ::|:
Human   285 LLCNTGHKCVFSDHGLLTTVA-YKLG-----RDK--PVYYALEGSVAIAGAVIRWLRDNLGIIKT 341

  Fly   337 HESYAELKSQLGEDKFIYQHLNKLLPELAAARGLSQVGCLTQDVHVWPDLHGNRSPIADPTLRGV 401
            .|...:|..::|                      :..||     :..|...|..:|..:|:.||:
Human   342 SEEIEKLAKEVG----------------------TSYGC-----YFVPAFSGLYAPYWEPSARGI 379

  Fly   402 ITGLDMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCGGLAKNPLYVQCHADI 466
            |.||  |:.|....|.:.| ::|:.:.||.|::.:.:....|...|...||:..|.:.:|..|||
Human   380 ICGL--TQFTNKCHIAFAA-LEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADI 441

  Fly   467 CNLPALIPDEQEMVLVGAA-ALGAAASGHFDSLESASKSMGGTGQLVKP--NAETLEFHNRKYK 527
            ..:|.:.|...|...:||| |.|||......|||....| ..|.:..:|  |||..|.....:|
Human   442 LYIPVVKPLMPETTALGAAMAAGAAEGVDVWSLEPEDLS-AVTMERFEPQINAEESEIRYSTWK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_647848.2	5C_CHO_kinase	6..540	CDD:273552	140/582 (24%)
GK3	NP_001382882.1	ASKHA_NBD_FGGY_GK1-3-like	11..510	CDD:466802	141/583 (24%)