Protein Alignment CG11594 and GK2

DIOPT Version :10

• Sequence 1: NP_647848.2
• Gene: CG11594 / 38473
• FlyBaseID: FBgn0035484
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_149991.2
• Gene: GK2 / 2712
• HGNCID: 4291
• Length: 553
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 121/542 - (22%)
• Similarity: 203/542 - (37%)
• Gaps: 135/542 - (24%)

  Fly     4 GPFFVGVDVGTGSARAALVACDGRVLE----QAVQTIQTWNPEPGYYNQSSDNIWQSICQVVKKV 64
            ||....|..||.|.|  .:..:.:..|    ..|:..|.: |:.|:..|....|.||:.:.:.:.
Human    10 GPLVGAVVQGTNSTR--FLVFNSKTAELLSHHKVELTQEF-PKEGWVEQDPKEILQSVYECIART 71

  Fly    65 IG-----GVDKSKVKGIGFDATCSLVVLGPQGSPLTVSKSGEAEQNIILWMDHRAEQETQEINAF 124
            ..     .:|.|.:|.:|........|:..:   ||    ||...|.::|:|.|.:...::::..
Human    72 CEKLDELNIDISNIKAVGVSNQRETTVIWDK---LT----GEPLYNAVVWLDLRTQTTVEDLSKK 129

  Fly   125 KHSLLKYVGGQVSLEM----EVPKLLWLKRNLSQT----------FGNIWRVFDLPDFLTWRAT- 174
            ......:|..:..|.:    ...||.|:..|:...          ||.|      ..:|.|..|
Human   130 IPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTI------DSWLIWSLTG 188

  Fly   175 GVDTRSLCSVVCKWNYDAANGS-----------WNKEFLKQADLE-ELTQNNFEKLGSDVQPPGR 227
            ||:....|:       |..|.|           |:||.....::. :|..|.|.  .|::.
Human   189 GVNGGVHCT-------DVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFS--SSEIY---- 240

  Fly   228 TVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGALGMFGCRSKESKGADDVQGKMALIAGTSTCHM 292
                ||....|.|     |..:|..|.|..|..:|....:..::|..          .||. |.:
Human   241 ----GLIKTGALE-----GVPISGCLGDQCAALVGQMCFQEGQAKNT----------YGTG-CFL 285

  Fly   293 --SITRKACFAQGVWGPYQDAII-----------PGYFLNEGGQSIAGHLLDHVLKSHESYAELK 344
              :..||..|:       :..::           |.|:..||..:|||.::          ..|:
Human   286 LCNTGRKCVFS-------EHGLLTTVAYKLGREKPAYYALEGSVAIAGAVI----------RWLR 333

  Fly   345 SQLGEDKFIYQ---HLNKLLPELAAARGLSQVGCLTQDVHVWPDLHGNRSPIADPTLRGVITGLD 406
            ..||    |.:   .:.:|..|:.     :..||     :..|...|..:|..:|:.||::.||
Human   334 DNLG----IIETSGDIERLAKEVG-----TSYGC-----YFVPAFSGLYAPYWEPSARGILCGL- 383

  Fly   407 MTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCGGLAKNPLYVQCHADICNLPA 471
             |:.|....|.:.| ::|:.:.||.|:|.:.:....|.:.|...||:..|.:.:|..|||.::|.
Human   384 -TQFTNKCHIAFAA-LEAVCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPV 446

  Fly   472 LIPDEQEMVLVGAAALGAAASG 493
            :.|...|...:|||....||.|
Human   447 IKPFMPETTALGAAMAAGAAEG 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_647848.2	5C_CHO_kinase	6..540	CDD:273552	119/540 (22%)
GK2	NP_149991.2	ASKHA_NBD_FGGY_GK1-3-like	11..510	CDD:466802	120/541 (22%)