Protein Alignment CG11594 and GK

DIOPT Version :10

• Sequence 1: NP_647848.2
• Gene: CG11594 / 38473
• FlyBaseID: FBgn0035484
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: XP_011543793.1
• Gene: GK / 2710
• HGNCID: 4289
• Length: 587
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 147/609 - (24%)
• Similarity: 225/609 - (36%)
• Gaps: 165/609 - (27%)

  Fly     4 GPFFVGVDVGTGSARAALV-ACDGRVLEQAVQTIQTWNPEPGYYNQSSDNIWQSICQVVKKV--- 64
            ||....||.||.|.|..:. :....:|......|:...|..|:..|....|..|:.:.::|.
Human    10 GPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEK 74

  Fly    65 IG--GVDKSKVKGIG-------------------FDATCSLVVLGPQGSPLTVSKSGE---AEQN 105
            :|  .:|.|.:|.||                   ::|..:.|..|| ..|:.|..||.   |...
Human    75 LGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGP-SVPVAVVPSGSSVPAPGT 138

  Fly   106 IILWMDHRAEQETQEINAFKHSLLKYVGGQ-----------VSLEMEVPKLLWLKRNLSQT---- 155
            ..:|:|.|. |.|.|      ||.|.:.|.           :|......||.||..|:.:.
Human   139 SSVWLDLRT-QSTVE------SLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAV 196

  Fly   156 ------FGNIWRVFDLPDFLTWRAT-GVDTRSLCSVVCKWNYDAANGS-----------WNKEFL 202
                  ||.|      ..:|.|..| ||:....|:       |..|.|           |:|:..
Human   197 EEKRALFGTI------DSWLIWSLTGGVNGGVHCT-------DVTNASRTMLFNIHSLEWDKQLC 248

  Fly   203 KQADLEELTQNNFEKLGSDVQPPGRTVGK--GL-----TAKAAGELGLSAGTVVSTSLIDAHAGA 260
            :           |..:..::.|..|:..:  ||     :.||    |...|..:|..|.|..|..
Human   249 E-----------FFGIPMEILPNVRSSSEIYGLMKISHSVKA----GALEGVPISGCLGDQSAAL 298

  Fly   261 LGMFGC----RSKESKGADDVQGKMALIAGTSTC----HMSITRKACFAQGVWGPYQDAIIPGYF 317
            :|.. |    ::|.:.|.    |...|......|    |..:|..| :..|     :|.  |.|:
Human   299 VGQM-CFQIGQAKNTYGT----GCFLLCNTGHKCVFSDHGLLTTVA-YKLG-----RDK--PVYY 350

  Fly   318 LNEGGQSIAGHLL----DH--VLKSHESYAELKSQLGEDKFIYQHLNKLLPELAAARGLSQVGCL 376
            ..||..:|||.::    |:  ::|:.|...:|..::|                      :..||
Human   351 ALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVG----------------------TSYGC- 392

  Fly   377 TQDVHVWPDLHGNRSPIADPTLRGVITGLDMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGR 441
                :..|...|..:|..:|:.||:|.||  |:.|....|.:.| ::|:.:.||.|::.:.:...
Human   393 ----YFVPAFSGLYAPYWEPSARGIICGL--TQFTNKCHIAFAA-LEAVCFQTREILDAMNRDCG 450

  Fly   442 APFQTLLFCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAA-ALGAAASGHFDSLESASKSM 505
            .|...|...||:..|.:.:|..|||..:|.:.|...|...:||| |.|||......|||....|
Human   451 IPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLS- 514

  Fly   506 GGTGQLVKP--NAETLEFHNRKYK 527
            ..|.:..:|  |||..|.....:|
Human   515 AVTMERFEPQINAEESEIRYSTWK 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_647848.2	5C_CHO_kinase	6..540	CDD:273552	145/607 (24%)
GK	XP_011543793.1	ASKHA_NBD_FGGY_GK1-3-like	11..544	CDD:466802	146/608 (24%)