Protein Alignment CG11594 and SHPK

DIOPT Version :10

• Sequence 1: NP_647848.2
• Gene: CG11594 / 38473
• FlyBaseID: FBgn0035484
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_037408.2
• Gene: SHPK / 23729
• HGNCID: 1492
• Length: 478
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 112/565 - (19%)
• Similarity: 193/565 - (34%)
• Gaps: 152/565 - (26%)

  Fly     1 MSSGPFFVGVDVGTGSARAALV--------------ACDGRVLEQAVQTIQTWNPEPGYYNQSSD 51
            |::.|..:|:|:||.|.:|||:              :|......:|........|      |..:
Human     1 MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGP------QGRE 59

  Fly    52 NIWQSICQVVKKVIGGVDKSKVK---GIGFDATCSLVVLGPQGSPLTVSKSG-------EAEQNI 106
            .....|.|.:.:.:..:.:.:::   |||.......||....|.....::.|       .|..::
Human    60 QDVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHL 124

  Fly   107 ILWMDHRAEQETQEINAFKHSLLKYVGGQVSLEMEVPKLLWLKRNLSQTFG-----NIWRVFDLP 166
            :.|.|.|...|      |..||              |:   .|.:||...|     ..|.:...|
Human   125 VTWQDGRCSSE------FLASL--------------PQ---PKSHLSVATGFGCATIFWLLKYRP 166

  Fly   167 DFL-TWRATGVDTRSLCSVVC-------------KWNY-DAANGSWNKEFLKQADLEELTQNNFE 216
            :|| ::.|.|.....:.:::|             .|.| :..:.|||.|.|:.:...       .
Human   167 EFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFP-------V 224

  Fly   217 KLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGALGMFGCRSKESKGADDVQGKM 281
            .|..|:..||...|:  |:....|  :..||.|..:|.|..|   .::.|.::.:....::...:
Human   225 HLLPDIAEPGSVAGR--TSHMWFE--IPKGTQVGVALGDLQA---SVYSCMAQRTDAVLNISTSV 282

  Fly   282 ALIAGTSTCHMSITRKACFAQGVWGPYQDAIIPGYFLN-EGGQSIAGHLLDHVLKSHESYAELKS 345
            .|.|...:...........|...:.||.:....|...: .||..:|..:  |:|      .:..:
Human   283 QLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFV--HML------VQWMA 339

  Fly   346 QLG---EDKFIYQHLNKLLPELAAARGLSQVGCLTQDVH--VWPDLHGNR---SPIADPTLRGVI 402
            .||   |:..:|..             :.|.....:|.|  :.|.:.|.|   ..:|..|.   |
Human   340 DLGLEVEESTVYSR-------------MIQAAVQQRDTHLTITPTVLGERHLPDQLASVTR---I 388

  Fly   403 TGLDMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCG---------GLAKNPL 458
            :..|::.|..:.|:            .|.|::||  :...|.|.|...|         .|::|.:
Human   389 SSSDLSLGHVTRAL------------CRGIVQNL--HSMLPIQQLQEWGVERVMGSGSALSRNDV 439

  Fly   459 YVQCHADICNLPALIPDEQEMVLVGAAALGAA---ASGHFDSLES 500
            ..|.......||.....:.:      ||:|||   ...|.:..||
Human   440 LKQEVQRAFPLPMSFGQDVD------AAVGAALVMLRRHLNQKES 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_647848.2	5C_CHO_kinase	6..540	CDD:273552	110/560 (20%)
SHPK	NP_037408.2	ASKHA_NBD_FGGY_SHK	6..468	CDD:466796	107/548 (20%)