DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12766 and dkgA

DIOPT Version :9

Sequence 1:	NP_647839.1	Gene:	CG12766 / 38462	FlyBaseID:	FBgn0035476	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_417485.4	Gene:	dkgA / 947495	ECOCYCID:	G7565	Length:	275	Species:	Escherichia coli

Alignment Length:	291	Identity:	108/291 - (37%)
Similarity:	162/291 - (55%)	Gaps:	33/291 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KHNDGTHIQGIGLGTFASTEGDCERAVLHAIDVGYRHIDTAYFYGNEAEVGAAVRKKIAEGVIKR 74
            |..||..:..:|||.:.::..:...|:..|::||||.||||..|.||..||.|::    ...:.|
E. coli     8 KLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK----NASVNR 68

  Fly    75 EDIFITTKLWCNFHEPERVEYACRKTLKNIGLDYVDLYLIHWPFSYKYRGDNELIPKDANGEVEL 139
            |::|||||||.:.|  :|...|...:||.:.|||:||||:|||                   |..
E. coli    69 EELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWP-------------------VPA 112

  Fly   140 VDIDYLDTWGAMEKLVDLGLTKSIGVSNFNEEQLTRLLANCKIKPIHNQIEVHPALDQKKLIALC 204
            :| .|::.|..|.:|...||.|||||.||....|.||:....:.|:.||||:||.:.|::|.|..
E. coli   113 ID-HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWN 176

  Fly   205 KKNGILVTAFSPLGRHNAELRTPTFMYDGKV-QAIADKYNKSIAQVVIRYVIELGTIPLPKSSNP 268
            ..:.|...::|||.:....      ::|.|| :.:||||.|:.||:|||:.::.|.:.:|||..|
E. coli   177 ATHKIQTESWSPLAQGGKG------VFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTP 235

  Fly   269 KRIEENFNVFDFKLDAEDHAILDSYHNGERV 299
            .||.|||:|:||:||.::...:.....|:|:
E. coli   236 SRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12766	NP_647839.1	ARA1	5..298	CDD:223729	107/288 (37%)
CG12766	NP_647839.1	Tas	12..299	CDD:223739	106/287 (37%)
dkgA	NP_417485.4	dkgA	1..275	CDD:183203	108/291 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	135	1.000	Domainoid score	I232
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	200	1.000	Inparanoid score	I161
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm51343
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
	9	8.760