Protein Alignment CG12766 and AKR1C4

DIOPT Version :10

• Sequence 1: NP_647839.1
• Gene: CG12766 / 38462
• FlyBaseID: FBgn0035476
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 138/312 - (44%)
• Similarity: 188/312 - (60%)
• Gaps: 11/312 - (3%)

  Fly    12 NDGTHIQGIGLGTFASTEGDCERAV---LHAIDVGYRHIDTAYFYGNEAEVGAAVRKKIAEGVIK 73
            |||..:..:|.||:|..|....|||   ..||:.|:||||:||.|.||.:||.|:|.|||:|.:|
Human    11 NDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVK 75

  Fly    74 REDIFITTKLWCNFHEPERVEYACRKTLKNIGLDYVDLYLIHWPFSYKYRGDNELIPKDANGEVE 138
            |||||.|:||||.|.:|:.|:.|...:||.:.||||||||:|:|.:.| .|:..| |||.||:|.
Human    76 REDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK-PGETPL-PKDENGKVI 138

  Fly   139 LVDIDYLDTWGAMEKLVDLGLTKSIGVSNFNEEQLTRLL--ANCKIKPIHNQIEVHPALDQKKLI 201
            ...:|...||..|||..|.||.|||||||||..||..:|  ...|.||:.||:|.||.|:|.||:
Human   139 FDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLL 203

  Fly   202 ALCKKNGILVTAFSPLG--RHN--AELRTPTFMYDGKVQAIADKYNKSIAQVVIRYVIELGTIPL 262
            ..||...|::.|.|.||  ||.  .:..:|..:.|..:.|:|.|:.::.|.:.:||.::.|.:.|
Human   204 DFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVL 268

  Fly   263 PKSSNPKRIEENFNVFDFKLDAEDHAILDSYHNGERVAHARQAIKSKYYPFN 314
            .||.|.:||.||..||:|:|.:||..:||..:...|.......:....|||:
Human   269 AKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYPFS 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12766	NP_647839.1	AKR_AKR2E1-5	7..299	CDD:381342	134/295 (45%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	135/296 (46%)