DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10357 and LIPG

DIOPT Version :9

Sequence 1:	NP_647821.2	Gene:	CG10357 / 38435	FlyBaseID:	FBgn0035453	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	XP_005258447.1	Gene:	LIPG / 9388	HGNCID:	6623	Length:	536	Species:	Homo sapiens

Alignment Length:	268	Identity:	88/268 - (32%)
Similarity:	132/268 - (49%)	Gaps:	23/268 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IVHGYLGS-----CTHGSIMPLRNAYTAQGYENVLVADWGPVANLDYPSSRLAVKNVAQILAKLL 117
            |:||:..|     ..|..:..|   :|.:...||:|.||.|:|:..|..:....:.|...:|::|
Human   124 IIHGWTMSGIFENWLHKLVSAL---HTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARML 185

  Fly   118 EEFLQRHGISLEGVHVIGHSLGAHIAGRIGRYFNGSLGRVTGLDPALPLFSSRS-DDSLHSNAAQ 181
            :...::...||..||:||:|||||:||..|.:..|::||:||||||.|:|.... ...|..:.|.
Human   186 DWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDAD 250

  Fly   182 FVDVIHTDYPLFG---DIR-PRGTVDFYPNFGLAPQPGCENVDVVA--ASKLLHEAYSCSHNRAV 240
            ||||:||....||   .|: |.|.:|.|||.| ..||||...||:.  |...:.|...|.|.|||
Human   251 FVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGG-DFQPGCGLNDVLGSIAYGTITEVVKCEHERAV 314

  Fly   241 MFYAESIGMPENFPAVSCSLTAIKSRRVEDCLREKSKTNTENANDYQTVFMGEHVNRSATLYYYL 305
            ..:.:|: :.::.|:.:...|  .|.|.:..:....:.|..|:..|....|....|..    .||
Human   315 HLFVDSL-VNQDKPSFAFQCT--DSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSK----MYL 372

  Fly   306 ETNGAPPY 313
            :|....|:
Human   373 KTRAGMPF 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10357	NP_647821.2	Pancreat_lipase_like	28..308	CDD:238363	86/261 (33%)
LIPG	XP_005258447.1	Pancreat_lipase_like	85..376	CDD:238363	87/262 (33%)
		lipo_lipase	86..521	CDD:132274	88/268 (33%)
		PLAT_LPL	383..519	CDD:238856
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8651
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040