Protein Alignment armi and HELZ2

DIOPT Version :10

• Sequence 1: NP_647816.2
• Gene: armi / 38427
• FlyBaseID: FBgn0041164
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_024307774.1
• Gene: HELZ2 / 85441
• HGNCID: 30021
• Length: 2677
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 137/570 - (24%)
• Similarity: 220/570 - (38%)
• Gaps: 147/570 - (25%)

  Fly   694 YN-----QSLNSIQKRAVFNILRGEAENIPY-VLFGPPGSGKTMTLIETLLQL------------ 740
            ||     ..||..|     |:...||...|: |:.||||:|||:..:..:...
Human  2172 YNIPGGRHKLNPSQ-----NVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGG 2231

  Fly   741 ----VRNLPGARILVGTPSNSSAD----LVTKRL---------------------IDSKALLQ-- 774
                .:.|.|..||...|||.|.|    |:.:|:                     :.|:.||:
Human  2232 PPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKS 2296

  Fly   775 ------GDFIRLVSYNQVEKDLIPP---EIMSYCATSDVGAVGSCED----KMMVTESGLKLRCQ 826
                  ...:|.::.:...:....|   ||.::......|.:.|.||    |.::.|:
Human  2297 PREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLWEA------- 2354

  Fly   827 AKF-IGTHRITISTCTTLGN----FLQLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQV 886
            .|| :..|.:.:.||:...:    .|.:       ..:|.||||..|||||::|:|.. .:..:|
Human  2355 RKFELDRHEVILCTCSCAASASLKILDV-------RQILVDEAGMATEPETLIPLVQF-PQAEKV 2411

  Fly   887 VLSGDPRQLQSIVTSRIASKMGFSISFLERLLE-----RSPYR--KDLQRFPESSGYNPLVLTKL 944
            ||.||.:||:.:|.:.....:|...|..||..|     .:.||  :.:..||..:.|...:  |.
Human  2412 VLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKL--KT 2474

  Fly   945 LYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFESEKDIPQAHGTFFYGIIGE 1009
            ....|..||::....:     |..||:........|.|                       ::..
Human  2475 WQGLRRPPSVLGHAGK-----ESCPVIFGHVQGHERSL-----------------------LVST 2511

  Fly  1010 NRQNNDSPSWFNPQEVREVFLMT--IALYRANVTADQIGIITPYQKQVKMLRSMFIGTDVVMPKI 1072
            :..|.:|.:  |.:||.||..:|  :.|.| .|....|.::|||..|...:........:....:
Human  2512 DEGNENSKA--NLEEVAEVVRITKQLTLGR-TVEPQDIAVLTPYNAQASEISKALRREGIAGVAV 2573

  Fly  1073 GSVEEFQGQERDIILISTVRSSEEILRMDARFS-------LGFVRCSKRLNVAVSRARAMMIIFG 1130
            .|:.:.||.|...:|:||||:..: ..:|.|.:       ||||....::||||:||:..:.:.|
Human  2574 SSITKSQGSEWRYVLVSTVRTCAK-SDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIG 2637

  Fly  1131 NPHLLAVDECWRQLILFCVKNNAYFGCDLPQMVINQKDEVPVCLETFVPS 1180
            :..||.....||.|:.||.          .|..:....:|.||....:||
Human  2638 DHLLLRCCPLWRSLLDFCE----------AQQTLVPAGQVRVCRRPTMPS 2677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_647816.2	DEXXQc_Mov10L1	697..949	CDD:350836	76/320 (24%)
		DNA2	<829..1148	CDD:440729	87/339 (26%)
HELZ2	XP_024307774.1	zf-C2H2_jaz	39..64	CDD:432381
		DNA2	106..915	CDD:440729
		DEXXQc_HELZ2-N	514..744	CDD:350834
		AAA_12	715..915	CDD:463780
		RNB	1334..1693	CDD:214935
		DEXXc_HELZ2-C	2180..2454	CDD:350798	70/293 (24%)
		AAA_12	2434..2639	CDD:463780	56/238 (24%)