DRSC/TRiP Functional Genomics Resources

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Protein Alignment kst and Sptbn2

DIOPT Version :10

Sequence 1:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster
Sequence 2:XP_008758314.1 Gene:Sptbn2 / 29211 RGDID:3751 Length:2395 Species:Rattus norvegicus


Alignment Length:2514 Identity:765/2514 - (30%)
Similarity:1222/2514 - (48%) Gaps:325/2514 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 QSLASQYEPGGYSALQTPTPSNRNSANMTQRDGIIKFENERIKTLQEERLHIQKKTFTKWMNSFL 89
            :::.....|||  .|.:|..    ..|..|...:::   .|.|.||:||..:||||||||:||.|
  Rat    23 EAVEGSQNPGG--ILLSPAA----FINPAQYASVLE---GRFKQLQDEREAVQKKTFTKWVNSHL 78

  Fly    90 IKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPNSGRMRVHKIENVNKSLAFL-HTKVRLESI 153
            .:....|.||::||.||..||:|||::|.|.|.||..||||:|.:|||:|:|.|| ..||.||::
  Rat    79 ARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENM 143

  Fly   154 GAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAKDALLLWCQRKTHGYPGVNI 218
            |:.||||||.||.|||:||||||||||:|.:   |..::.||:|||||||||||.||.|||.||:
  Rat   144 GSHDIVDGNHRLTLGLVWTIILRFQIQDISV---ETEDNKEKKSAKDALLLWCQMKTAGYPNVNV 205

  Fly   219 TDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLD-NLNHAFDTAANELGIPSLLDAEDID 282
            .:||.|||.||.|||::|.|||||.::.::   |..|.. ||.:||:.|..|||:..|||.||::
  Rat   206 HNFTTSWRDGLAFNAIVHKHRPDLLDFESL---KKCNAHYNLQNAFNLAEKELGLTKLLDPEDVN 267

  Fly   283 SARPDEKSILTYVASYYHTFARMKNEQKSGKRIANIVGQLMDADRKKMQYEGLTTNLLSWIRQKT 347
            ..:||||||:||||:|||.|::||.....||||..::...|:|:....:||.|.:.||.||.|..
  Rat   268 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAEHLVEKYESLASELLQWIEQTI 332

  Fly   348 LELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEALYFTINTLLKALNQPPYNPQDGQ 412
            :.|..|.|.|||.|:|.:|.:|..|||:|||||:.|:..:|.|.|||.:.|:|.||..|.|::|:
  Rat   333 VTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGR 397

  Fly   413 LVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKKSVLREGYLKEMIQVLSDPRY-- 475
            |::||.|||:.||.|||.||:|||.||:||||||||..:|::|:.:||.:|.|..:::|...:  
  Rat   398 LISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGL 462

  Fly   476 -LRQVDATLKKHEAISADILARVERFNDLTAMAEELDRENYHGKERVRRREQEVMAKWRQLLELL 539
             |..|:|.::|||||..||:|...|...:.|:|.||..|:||..:|:..|:..|...|..|.|::
  Rat   463 ELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMV 527

  Fly   540 ENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPHLLGVEELLQAHSLQELQVNTYGE 604
            ..:|..|.....|..:.:::....:.:.|::.:..|:|:|.||.|||:|||.|.|.|..:....|
  Rat   528 AARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAE 592

  Fly   605 TLKRFNRQAL----PYKSSEHKDAALLAQRLADLEEAYSELLRRSAARRARLEEARNFHHFMEDY 665
            .::..:..||    |.|.....|..|:::|:|.||::|..|...:|.|||||||:|....|:.:.
  Rat   593 RVRAVSASALRFCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEV 657

  Fly   666 DNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALEDEIKSRKPKSGQMSTAGKRLIGEQHPRS 730
            ...|:|:.::|.:..:..|.:||..||.|..||.||..|:..|..........|::|:.|.||.:
  Rat   658 GEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA 722

  Fly   731 SEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDANEAESWLNEKIALVNSRDYGNDEP 795
            ::..:|...|...|:.||||.|.|.::|..||..|||..|||:.|:||.:.:.||:|.:.|:||.
  Rat   723 NQASTRAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEF 787

  Fly   796 SAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKAGICTLELSAAEPELPEVEQEEWVNETRLV 860
            |.|||.::||.|:.|:.|:...:..|.:||..|                                
  Rat   788 STQALARQHRALEEEIRAHRPTLDALREQAAAL-------------------------------- 820

  Fly   861 PKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQGMKMDKGEVMLLKSKTNDDWWCVRKDNGV 925
                                                                             
  Rat   821 ----------------------------------------------------------------- 820

  Fly   926 EGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKTILVRQVVPVKRIKPVSVAPKPLVQRRTST 990
                                                             |.:::..|.||.|..|
  Rat   821 -------------------------------------------------PPALSHTPEVQGRVPT 836

  Fly   991 QSINENADSVEKRQQRINQTYDELQEMAQKRHALLEDSIHLFGFYRECDDFEKWMKEKERMIKS- 1054
                            :.|.|:|||..|.:|...||.::..:....|......|::|||:.:.. 
  Rat   837 ----------------LEQHYEELQARAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGL 885

  Fly  1055 ---DEGEGVDNAKRKFEKFITDLSAASKRVEEIDGAVDTFRRQGHSQLDKIIARQRQIHQIWQRL 1116
               :..|.::..:::||....:::|.:.||..:....:...:......|:||..|.|::|.||:.
  Rat   886 ALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQF 950

  Fly  1117 NNAKAQREKSLEGASSVELFNRTCDEAKVWMSEKMLQLD-TAVITPDLRTVQALQRRHQNLEREL 1180
            .:....::.:|..|.|::.::..|.|.:.||.||...:: |..:..||..|.||||:....||:|
  Rat   951 RSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDL 1015

  Fly  1181 APVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQDMWQQVQQRGSDLRNRIESEVGQ----QV 1241
            ..:..:|..:|...|::...:||:...:|.|..|||..|:.::   :.:|.|.|| :|:    |.
  Rat  1016 EAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLR---ATMRRREES-LGEARRLQD 1076

  Fly  1242 FNNSAKVLLAWIDSVKDQLNADESARDVETANNLLKKHNDLGDDIRAHDTEFVEVIQLGKQLS-- 1304
            |..|.....||:...:..:.::|....:..|..||.:|..|..::....:|:..:..||::::  
  Rat  1077 FLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRTLGEEVTRD 1141

  Fly  1305 DGKPNMAETVAVIERLKAEQDAIHRGWAEKQKWLLQCVDLQMFNREADKIDATTKSHEAFLEYNN 1369
            ...|........:|.|....:.:.|.|..:|..|.|....|.|.|:|.:.:....|.|..|.:..
  Rat  1142 QADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE 1206

  Fly  1370 LGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYDSKYIGDRRNQVLGKRKAVK 1434
            :..:|...:|.:|:..||..::.|..:.::|..:...:|:|..:..::.|.::.:.:..:.:..:
  Rat  1207 MPGTLQAADAAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQ 1271

  Fly  1435 DRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENYRDLSNLPRKLQKHQAFERELRAN 1499
            :...:....|:.:::...|..:..:||:|:.:|...|.|.:|.:..||..|.||||||..||.||
  Rat  1272 EAVQQLLGRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1336

  Fly  1500 EGQLRNVTKDGQALVQAGNRVPE----VESRVADLNKRWKDLLTLSEDKGRKLEQAASQREHNRS 1560
            :..|..|.|:|:.|..   ..||    |..::.||::||.:|.|.::.|.|.|..|.......:|
  Rat  1337 KDWLDKVDKEGRELTL---EKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQS 1398

  Fly  1561 LEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQILESEITIWDQKVAELVSTGDDMAHGGHFN 1625
            ....:..::.|.:.|.|.|.|.||.|...|:.|||:||.|:.:.:::|..:.:....:|.... :
  Rat  1399 CSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQ-S 1462

  Fly  1626 AQNIEAGTKELQQRFKDLRDPTQRRRAKLEESLNYHKFVFELDSEFQWINEHLPAAKSNELGQNL 1690
            |..:|..::.::::|:.|..|.:.|..:|:.|...|:|..:::.|..|:.|.||.|.|.|.|::|
  Rat  1463 AGEVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEHGKDL 1527

  Fly  1691 HQAQSLHKKHKKLEAEIKGHQPMINKALVAGQSL-ISQQHPEREQVESLCQQLEQAWQDLERHCG 1754
            ...|.|.||::.|:.||:||:|.|.......::| .:...||       ..:|::.|:.|.....
  Rat  1528 PSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTLGTAAAGPE-------LAELQEMWKRLSHELE 1585

  Fly  1755 ERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRSTEYGRDRDSAAKLLTKHKTIELELDTYSGI 1819
            .|.::|:.:|:|||:..||.|.|:|:||:...:...|..:|..||...:.||:.:|..|..|:..
  Rat  1586 LRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQT 1650

  Fly  1820 VTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKSLHKLASQRQGRLMESLYKHEYFLESDEVEQ 1884
            :.::..|...|:...||:|..|..:|..::|:...|.:||.:|:.||.|.|...:...|.|::||
  Rat  1651 IKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQ 1715

  Fly  1885 WIREQEQAASSEDYGQDFEHLQLLQNKFDDLKHRVE-VGADRVDQCELLAKKLIDSESPYANEVE 1948
            ||:|:|..|:|.:.|||:||:.:|::||.:...... :|.:|||....||..||.........|.
  Rat  1716 WIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1780

  Fly  1949 KRQEQLRTSWENLLQLLNQREQKLHAAGEIHRFHRDVAEALFRIQDKNAALSQELGRDLNSALAL 2013
            :.::.|..:|.:||:||:.|.|.|.||.|:.||.....:||.|:|.|...|....|||||:|.||
  Rat  1781 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEAL 1845

  Fly  2014 LRKHEGFENDLVALEAQLQVLVEDSVRLQAKYPSN-ASAIAQQQDKVVAAWNDLKERSTARGDRL 2077
            .|:|..:|:|:.||..|:|.:.:|.:|||..|..: |..|.:....|..||..|:..|.||...|
  Rat  1846 QRRHCAYEHDIQALSTQVQQVQDDGLRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLL 1910

  Fly  2078 AASSDLQTFLTDVRDIVSWSSNLRAALQAEEHVSDAAGATALKIQHDAIYGEIEAREDKFRYLNE 2142
            ..::|...|...||:::.|...:...:.|:|...|.:.|..:......|..|||||.|:|....:
  Rat  1911 LDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSACID 1975

  Fly  2143 LSDSMVQTGHYAAADVEEKCAAMLDERQKLHAAWNKKKIMLEQKIDLFCFLRDAKQIDNLSSSQQ 2207
            :...::...||||.::.||.:.:...||:....|.:|...|:..:::..|.|||...:....||:
  Rat  1976 MGQELLARNHYAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQE 2040

  Fly  2208 AALSSSDFGQTVEDVQNKIRKHDEFERLIQTQEEKVSLLQ----------EHGRKLIEQRHYDSA 2262
            ..:.|::.|.||::|::.|::|:.|::.....||:.|.|:          |..||..|:      
  Rat  2041 PLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEERENEQKRKREEE------ 2099

  Fly  2263 NIQTILQGVLARRQKVKDLCAVRRYKLEDALLYAKFVRDCAEAKYWINEKQKKL--EADAASYAE 2325
                       .|:|..........:.|.:|:..:.|.|.|    | :..|.||  ...|.|...
  Rat  2100 -----------ERRKQPPTSEPMASQPEGSLVDGQRVLDTA----W-DGTQSKLPPSTQAPSING 2148

  Fly  2326 VTNLDEKIKKLQKHQAFQ-------------------------------------------AEVA 2347
            |....|..:.|.:.|..:                                           |.||
  Rat  2149 VCTDTESSQPLLEQQRLEQSNVPEGPGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSESAHVA 2213

  Fly  2348 ANQGRIQEI--QDTGVILLSKQHESSPEIKRAIEIVLEAWQGLLAELEQRGRG------------ 2398
            ....|..|:  |:.....|.::.|.....|:|..   .:||.:...|.:...|            
  Rat  2214 TLPARGAELSAQEQMEGTLCRKQEMEAFNKKAAN---RSWQNVYCVLRRGSLGFYKDARAASAGV 2275

  Fly  2399 ---------LEEAQDSLEFNSQLDK--IEAWIRD-KEMMVQASD 2430
                     |..||.|:.|:.:..|  .:..::| ||.:.||.|
  Rat  2276 PYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKD 2319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 66/115 (57%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 62/106 (58%)
SPEC 450..640 CDD:238103 62/196 (32%)
SPEC 658..832 CDD:238103 61/173 (35%)
SH3 885..935 CDD:214620 0/49 (0%)
SPEC 1030..1236 CDD:238103 53/210 (25%)
SPEC 1134..1341 CDD:238103 54/213 (25%)
SPEC 1343..1551 CDD:238103 56/211 (27%)
SPEC 1449..1658 CDD:238103 64/212 (30%)
SPEC 1555..1764 CDD:238103 57/209 (27%)
SPEC 1765..1975 CDD:238103 71/210 (34%)
SPEC 1873..2080 CDD:238103 78/208 (38%)
SPEC 1979..2185 CDD:238103 67/206 (33%)
SPEC 2188..2402 CDD:238103 54/291 (19%)
SPEC 2407..2618 CDD:238103 8/27 (30%)
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
Sptbn2XP_008758314.1 CH_SPTB-like_rpt1 52..166 CDD:409095 66/116 (57%)
CH_SPTBN2_rpt2 180..298 CDD:409170 67/120 (56%)
Spectrin 312..421 CDD:395348 53/108 (49%)
Spectrin 436..529 CDD:395348 32/92 (35%)
SPEC 541..753 CDD:238103 68/211 (32%)
SPEC 756..965 CDD:238103 63/370 (17%)
SPEC 968..1179 CDD:238103 55/214 (26%)
SPEC 1181..1390 CDD:238103 56/211 (27%)
SPEC 1391..1595 CDD:238103 57/211 (27%)
SPEC 1596..1808 CDD:238103 72/211 (34%)
SPEC 1809..2017 CDD:238103 67/207 (32%)
SPEC 2025..>2082 CDD:197544 18/56 (32%)
PH_beta_spectrin 2228..2331 CDD:269975 20/95 (21%)
Blue background indicates that the domain is not in the aligned region.

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