Protein Alignment kst and sptb

DIOPT Version :10

• Sequence 1: NP_001097492.2
• Gene: kst / 38418
• FlyBaseID: FBgn0004167
• Length: 4337
• Species: Drosophila melanogaster
• Sequence 2: XP_002936942.2
• Gene: sptb / 100489265
• XenbaseID: XB-GENE-492725
• Length: 2342
• Species: Xenopus tropicalis
• Alignment Length: 2601
• Identity: 744/2601 - (28%)
• Similarity: 1255/2601 - (48%)
• Gaps: 371/2601 - (14%)

  Fly    20 ISYERQ--SLASQYEPGGYSALQTPTPSNRNSANMTQRDGIIKFENERIKTLQEERLHIQKKTFT 82
            :..|:|  ::.|::|     .::....::.:||.|        ||..|||.|.:||..:||||||
 Frog     9 LEIEQQYCTINSRWE-----TVEDDLDNDNSSARM--------FERSRIKALADEREAVQKKTFT 60

  Fly    83 KWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPNSGRMRVHKIENVNKSLAFL-HT 146
            ||:||.|......:.||:.||.||..|:||||::|.|:|.:...||||:|.:|||:|:|.|| ..
 Frog    61 KWVNSHLAFVSCRISDLYLDLRDGRMLIKLLEVLSGEQLPRRTKGRMRIHCLENVDKALHFLKEQ 125

  Fly   147 KVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAKDALLLWCQRKTH 211
            :|.||:||..|||:||.||:||||||||||||||:|.|    |.:.||.||||||||||||.||.
 Frog   126 RVHLENIGPHDIVNGNHRLVLGLIWTIILRFQIQDIII----EMKGSETRSAKDALLLWCQMKTA 186

  Fly   212 GYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNL-DNLNHAFDTAANELGIPSL 275
            |||.||:|:||:|||.||.||||||.||||||::..:   |.||. .||.||||||.::|||..|
 Frog   187 GYPNVNVTNFTSSWRDGLAFNALIHKHRPDLFDFERM---KKSNAKHNLEHAFDTADHKLGITQL 248

  Fly   276 LDAEDIDSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANIVGQLMDADRKKMQYEGLTTNLL 340
            ||.||:.:..||||||:|||.::||.|::||.....||||..::...::.|:...:||.||::||
 Frog   249 LDPEDVLTENPDEKSIITYVVAFYHYFSKMKALAVEGKRIGKVLDNAIETDKMIYEYESLTSDLL 313

  Fly   341 SWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEALYFTINTLLKALNQPP 405
            :||.|..|.|..|...|||.|:|::|.||..|||.|||||::|:..:|.|.|||.:.::...|..
 Frog   314 TWIEQTILALINRTFANSLTGVQQQLQAFSAYRTTEKPPKFQEKGYLEVLLFTIQSRMRENKQKV 378

  Fly   406 YNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKKSVLREGYLKEMIQVL 470
            |.||||:||:||.:||..||.|||.||.|||:||:||||||||..:|::|:.:||.::.|...::
 Frog   379 YVPQDGKLVSDINRAWGRLEKAEHDRETALRNELIRQEKLEQLAKRFDRKAAMRETWISENQHLI 443

  Fly   471 SDPRY---LRQVDATLKKHEAISADILARVERFNDLTAMAEELDRENYHGKERVRRREQEVMAKW 532
            :...:   |..|:|..||||||..||.|..||...|..:|:||:.|.||...|:..|:..::..|
 Frog   444 AQDNFGFDLPSVEAAKKKHEAIETDIYAYEERIQALVNVAKELENERYHDIRRISARKDNIVRLW 508

  Fly   533 RQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPHLLGVEELLQAHSLQEL 597
            :.|||:|:::|..|:....|..|.:|:......:.|::....|:|.|.|||.||.|||.|||.|.
 Frog   509 QYLLEILKSRRNRLNMTVELQTLFQEMLHIVNWMDEIKGGLLSQDYGKHLLEVEYLLQKHSLTEA 573

  Fly   598 QVNTYGETLKRFNRQALPYKSSEHK---DAALLAQRLADLEEAYSELLRRSAARRARLEEARNFH 659
            .:....:.:|.|::.||.:...:..   |..::..|:..||..|.||:..:|.||..|:::|...
 Frog   574 DIAAQADKVKSFSQAALKFVGGDGYQPCDPQVIKDRVQHLELCYQELVSLAAQRRHNLQQSRCLW 638

  Fly   660 HFMEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALEDEIKSRKPKSGQMSTAGKRLIG 724
            .|..|.:....|:.:|::|..:....|||.::..||:||:|.|||:|..:.........|:::|.
 Frog   639 KFFGDIEEVARWIREKEQIYTSMDFGKDLTSISILQRKHRAFEDELKGLETNLQHTLKDGEQMIA 703

  Fly   725 EQHPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDANEAESWLNEKIALVNSRD 789
            .:|..|.:|:.:|:::...|..|:.|...|.:.|.|....:||..||::..:.:.:...::.|.|
 Frog   704 NKHYASPKIKEQIENIKVQWAQLKDLAAFRLKILCDTENFFQFQVDADDLAARMQDTYRMMQSDD 768

  Fly   790 YGNDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKAGICTLELSAAEPELPEVEQEEWV 854
            .|:||.|.:.|:::.:||..::
 Frog   769 VGHDEYSTKILVKKQKDLLDDI------------------------------------------- 790

  Fly   855 NETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQGMKMDKGEVMLLKSKTNDDWWCV 919
                              :.::||.|.  |..|...||.|               .||:.:
 Frog   791 ------------------MINRKVLEG--LSEVVQRFPEE---------------FKTSPE---- 816

  Fly   920 RKDNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKTILVRQVVPVKRIKPVSVAPKPLV 984
                                                                             
 Frog   817 ----------------------------------------------------------------- 816

  Fly   985 QRRTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHALLEDSIHLFGFYRECDDFEKWMKEKE 1049
                           ::.|.|::...:.:|..:|..|...|:|::..:....:.|..|.||.|||
 Frog   817 ---------------IDSRLQKLRALFSDLASLADLRSQKLQDALSFYTVLGDIDACEMWMNEKE 866

  Fly  1050 RMI------KSDEGEGVDNAKRKFEKFITDLSAASKRVEEIDGAVDTFRRQGHSQLDKIIARQRQ 1108
            :.:      :|.|..||  .:.:|.....::.|...::::::.|.:.....||....|:......
 Frog   867 KWLEKMEIPESLEDMGV--VQHRFNTLDQEMGALGSQIQDVNTAANALIESGHPSRKKVKEDLDH 929

  Fly  1109 IHQIWQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSEKMLQLDTAV-ITPDLRTVQALQRR 1172
            ::..|.......:|:.::::.|..:..:...|||.|.|:.||:..:::.. :..||.:|.::||:
 Frog   930 MNSRWTVFQEMVSQKRRAVDSALGLHNYGVECDETKNWIIEKIKVVESIQDLGSDLASVMSIQRK 994

  Fly  1173 HQNLERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQDMWQQVQQRGSDLRNRIESEV 1237
            ...:||:||.:|.|:..:......:.|.:|.:..|:..|..::...|:::|:.   |:|:.||
 Frog   995 LYGIERDLAAIEAKLINLQGDAQKLANDHPDQAQNILDRLIDINKKWEELQKA---LQNQEES-- 1054

  Fly  1238 GQQVFNNSAKV---------LLAWIDSVKDQLNADESARDVETANNLLKKHNDLGDDIRAHDTEF 1293
                ...|:||         ...|:...:....:::....:..|..|...|..|.|||..|:.:|
 Frog  1055 ----LGESSKVQKFLVDLFDFETWLYRAQQATASEDIPTSLPEAEKLYANHLSLKDDIERHEPDF 1115

  Fly  1294 VEVIQLGKQLSDGK--PNMAETVAVIERLKAEQDAIHRGWAEKQKWLLQCVDLQMFNREADKIDA 1356
            .:|:..|.:::.|:  |...:.......:|...:.:|:.|..::|.|.||::.|.|.::|.:.:|
 Frog  1116 CDVVDTGNKVTSGQTDPQYEQLDQRGNDIKEGWNDLHKMWDNREKSLSQCLEFQKFLKDAKQSEA 1180

  Fly  1357 TTKSHEAFLEYNNLGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYDSKYIGD 1421
            ...:.|....:..:..:|...:..||:|.||          |....:|.:|::...::..|...|
 Frog  1181 ILSNQEYTFAHIEVPTTLQASQTRLKKHEDF----------LATMENNDEKIVGTINHGKKLDED 1235

  Fly  1422 RR---NQVLGKRKAVKDR-------AFERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENY 1476
            :.   ::.|||...:::|       |.|...||:.:.|...|....::|.:|:.:|...|.|.:|
 Frog  1236 KNVFADKALGKISFIEERYAKNLNKAKEVSILLKDNCDLQNFLENCEELNIWINEKMLTAQDTSY 1300

  Fly  1477 RDLSNLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNR-VPEVESRVADLNKRWKDLLTL 1540
            ....||..|..|||||:.||.:|:.:|.|:.|:|:.|.|...: .|.:..::::|::.|.:|.|.
 Frog  1301 DGARNLHSKWLKHQAFKAELDSNKERLENLDKEGKQLAQEKEQFAPIISEKLSELHRLWDELETT 1365

  Fly  1541 SEDKGRKLEQAASQREHNRSLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQILESEITIWD 1605
            :..|.:.|..|.....:.:...|..|.:.:::..::|.|.|.||.|...|:||.:.:|.:|   .
 Frog  1366 TLQKEQSLFDAHRTELYEQRYADLNKWIKDMEQQVKSDDCGTDLTSVNILLNKHKRIEDQI---Q 1427

  Fly  1606 QKVAELVSTGDDMAHGGHFNAQNIEAGTKELQQRFKDLRDPTQRRRAKLEESLNYHKFVFELDSE 1670
            ||..|:    |.:........:..:....|:..||..|....|.|:.||..|...|:...:|:.|
 Frog  1428 QKTIEM----DQVLPQASALGKEPDEKEPEINVRFLQLEPLMQERKRKLLSSKQVHQLHRDLEDE 1488

  Fly  1671 FQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQSLISQQHPEREQV 1735
            ..||.|.||.|:|.:.|.||...|.|.||::.|:.||.||.|.|...|:..:.:......:.:.:
 Frog  1489 ILWIQERLPLAESQDYGNNLQTVQMLMKKNQTLQKEIAGHSPRIEDVLMRAKHIEHDADIDDQPI 1553

  Fly  1736 ESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRSTEYGRDRDSAA 1800
            |...:.||::|.:|::...||.:.|..:|:|..|..||||.|:|:.|:...|...|..:|.:|..
 Frog  1554 EKKRKSLEESWDNLQKQIAEREKHLLQALEAHHYYMDAGEAEAWIDEQQLYLIGDEQPKDEESVV 1618

  Fly  1801 KLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKSLHKLASQRQGR 1865
            .:|.||..::..::.|...:.::......::|..||||:.:...|..|||...:|..:|.:::.:
 Frog  1619 AMLKKHLNLQHAVEHYGKNIKDLADQAQKLLALEHPDSERITRHQGNIEKQYAALRDMADEKRQK 1683

  Fly  1866 LMESLYKHEYFL--ESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDLKHRVEV-GADRVD 1927
            | :::| |.:.|  |.:::||||.|::..|||::.|||.:|:.:|::||.|......| |.:|:|
 Frog  1684 L-DNIY-HMFQLRREVEDLEQWIAERDVKASSQEMGQDLDHVSILRDKFRDFARETGVIGQERID 1746

  Fly  1928 QCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHRFHRDVAEALFRI 1992
            ...:|.::|||:....|..:.:.::.|..||.:||:|::.|.|.|.|:.|:|:|..|..|.|..|
 Frog  1747 NVNILIEQLIDAGHADAAMIAEWKDNLNESWADLLELIDTRVQLLSASYELHKFFYDGTEILSMI 1811

  Fly  1993 QDKNAALSQELGRDLNSALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAKYP-SNASAIAQQQ 2056
            ::|:..|.::||.|:::|.:|.|.|..||.|:..:.:|:|...:.:.||.|.|. :.|..|.:::
 Frog  1812 EEKHKELPEDLGGDVHTAQSLHRVHTAFERDIHFIGSQVQHFQDTAARLYAAYAGTQAVDIQKKE 1876

  Fly  2057 DKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEEHVSDAAGATALKI 2121
            .:||.||..|.:....|...|.::::...|.:.|||::.|..|:...::.:|...|.:....|..
 Frog  1877 QEVVEAWKGLLDACDGRRTELISAAEKFRFFSMVRDLMLWMENMIRQIETQEKPRDISSVEYLIK 1941

  Fly  2122 QHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLHAAWNKKKIMLEQK 2186
            .|..:..|||||...:....:|.::::...|.|:.:::||...:.:.|:::...|:|:...|...
 Frog  1942 YHQELKAEIEARNVTYTACVDLGNTLLARNHPASEEIKEKLVQLEERREEMMEKWHKRWDWLSIL 2006

  Fly  2187 IDLFCFLRDAKQIDNLSSSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQTQEEKVSLLQEHGR 2251
            :::..|.|||...::...|::..|.|:..|.:|:||:..||:|:.||:...|.||:.|.|:
 Frog  2007 LEVCQFARDASMAESWLISKEPYLYSTYVGNSVDDVEKLIRRHESFEKSTLTWEERFSALE---- 2067

  Fly  2252 KLIEQRHYDSANIQTILQGVLARRQKVKDLCAVRRYKLEDALLYAKFVRDCAEAKYWINEKQKKL 2316
                                   |....:|..||:|                       ::.|:.
 Frog  2068 -----------------------RLTTLELLEVRKY-----------------------QEAKRH 2086

  Fly  2317 EADAASYAEVTNLDEKIKKLQKHQAFQAEVAANQGRIQEIQDTGVILLSKQHESSPEIKRAIEIV 2381
            |...|:.:|:....:|.::.|.|:..:.||.|   .|....|:.|:     .|..|.:....|:.
 Frog  2087 EMLMAAESEMKETAQKEQQFQTHEEKEHEVKA---IIHAAPDSPVL-----EELKPRLPSITEVT 2143

  Fly  2382 LEAWQGLLAELEQRGRGLEEAQDSLEFNSQLDKIEAWIRDKEMMVQASDTG--RDLEHCNALMRK 2444
            .|..:....::.|......|:.:..|::.    ::...|..|.....:|:|  ..::|...|.||
 Frog  2144 EETKEKEEEKITQEEYTHTESMEQTEYSI----LDPETRQIEATTLPTDSGSSSSIQHQGYLNRK 2204

  Fly  2445 LDDVDSDMRVDDQR--------VKHIN----------QLADKLINQAQVPADTQSVD-----KRR 2486
             .|:|..::....|        :|:.:          .|.:....:..:|....|.:     |::
 Frog  2205 -HDLDGTLKKAANRSWNNVYCVLKNHDLYFYKDAKCFALNEAFQGEGPLPLRNASCEIVADYKKK 2268

  Fly  2487 KDFNYNWRQLQGALNAYRALLGGANE--------------IHVFNRDVDDTAD-RIAEKSLAMSS 2536
            |             :.:|..||..||              :.:....:.:..| :...|||.:.|
 Frog  2269 K-------------HVFRLRLGDGNEWLFQAKDEADLQTWVPILATTITEATDHKPKSKSLPLPS 2320

  Fly  2537 T 2537
            |
 Frog  2321 T 2321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kst	NP_001097492.2	CH_beta_spectrin_rpt1	61..176	CDD:409042	65/115 (57%)
		CH_beta_spectrin_rpt2	196..302	CDD:409043	69/106 (65%)
		SPEC	450..640	CDD:238103	63/195 (32%)
		SPEC	658..832	CDD:238103	42/173 (24%)
		SH3	885..935	CDD:214620	6/49 (12%)
		SPEC	1030..1236	CDD:238103	47/212 (22%)
		SPEC	1134..1341	CDD:238103	50/218 (23%)
		SPEC	1343..1551	CDD:238103	56/218 (26%)
		SPEC	1449..1658	CDD:238103	58/209 (28%)
		SPEC	1555..1764	CDD:238103	59/208 (28%)
		SPEC	1765..1975	CDD:238103	67/212 (32%)
		SPEC	1873..2080	CDD:238103	72/210 (34%)
		SPEC	1979..2185	CDD:238103	57/206 (28%)
		SPEC	2188..2402	CDD:238103	44/213 (21%)
		SPEC	2407..2618	CDD:238103	29/171 (17%)
		SPEC	2514..2725	CDD:238103	6/25 (24%)
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103
		SPEC	3465..3680	CDD:238103
		PH_beta_spectrin	3801..3904	CDD:269975
sptb	XP_002936942.2	CH_SF	26..155	CDD:469584	68/136 (50%)
		CH_SF	168..279	CDD:469584	72/113 (64%)
		SPEC	311..523	CDD:238103	96/211 (45%)
		SPEC	421..635	CDD:238103	70/213 (33%)
		SPEC	639..846	CDD:238103	59/368 (16%)
		SPEC	743..952	CDD:238103	49/372 (13%)
		SPEC	954..1166	CDD:238103	51/220 (23%)
		SPEC	1169..1269	CDD:197544	23/109 (21%)
		SPEC	1273..1475	CDD:238103	58/208 (28%)
		SPEC	1477..1688	CDD:238103	63/211 (30%)
		SPEC	1583..1795	CDD:238103	68/213 (32%)
		SPEC	1796..2018	CDD:238103	62/221 (28%)
		Spectrin	2011..>2065	CDD:395348	19/53 (36%)
		PH_beta_spectrin	2197..2296	CDD:269975	18/112 (16%)