Protein Alignment kst and sptbn4a

DIOPT Version :10

• Sequence 1: NP_001097492.2
• Gene: kst / 38418
• FlyBaseID: FBgn0004167
• Length: 4337
• Species: Drosophila melanogaster
• Sequence 2: XP_073808197.1
• Gene: sptbn4a / 100003123
• ZFINID: ZDB-GENE-060531-133
• Length: 1409
• Species: Danio rerio
• Alignment Length: 1480
• Identity: 325/1480 - (21%)
• Similarity: 571/1480 - (38%)
• Gaps: 353/1480 - (23%)

  Fly  1478 DLSNLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNRVPE----VESRVADLNKRWKDLL 1538
            :...|.||..|||||..||..|:..|..:.::|:.|:|   ..||    ||.::.::.:.|..|.
Zfish    11 EAQKLHRKWMKHQAFMAELARNKEWLAKIEQEGEELIQ---EQPELRSVVEMKLKEIRECWSHLE 72

  Fly  1539 TLSEDKGRKLEQAASQREHNRSLEDAKKKVDELDSAL-----RSGDVGNDLRSCKDLIN-----K 1593
            ..::.|.|:|    .:.:::|:.:.....:.:||..|     :...:|:...:...|:.     .
Zfish    73 NTTKVKARQL----FETQNHRTTDLPTNNLSDLDQHLNIIQEQPPTLGSTHTTQPTLLQPRPTFS 133

  Fly  1594 QQILESEITIWDQKVAELVSTGDDMAHGGHFNAQNIEAGTKELQQRFKDLRDPTQRRRAKLEESL 1658
            ||:  ..|..|:.::.......:.||...|...:..|.|... :.|...|.:|.:.||..|..|.
Zfish   134 QQL--QRIQSWEDQMQLFHGVSEVMAGAEHRRPEGEEQGGVP-ETRIVRLIEPLKERRRILLASK 195

  Fly  1659 NYHKFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQS 1723
            ..|:...:|:.|..||.|.|..|.|.|.|.||...|:|.|.|:.|:.|::..:..:.:.|...::
Zfish   196 ELHQVTQDLEDEIIWIQERLHLASSIEYGTNLQSVQNLMKNHEALQMEMQVRKGRLEEVLERAEA 260

  Fly  1724 LISQQHPEREQVESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWL-GERNNVL 1787
            :.:.:.||.|.|......:.|.|:.|:.....|:..||...:||||...|.:.|||| |::..||
Zfish   261 VAALRTPEVELVREGAGHVRQLWEVLQVEMERRTVMLDAVNQAQQYYSQAAKTESWLSGQKLQVL 325

  Fly  1788 RSTEYGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKML 1852
             :.|.|.|..|..:||.:...:|..::.|:..|..:...|..|:...||||:.:..:|..|:::.
Zfish   326 -NEEKGNDEASTLRLLKEQLALEQTVENYAETVGSLSQQCRRMLELGHPDSEQITKQQAHIDRLY 389

  Fly  1853 KSLHKLASQRQGRLMESLYKHEYFLESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDLKH 1917
            .||..|..||:.:|.:..:.::...|.:.:|:||.|:|..|||.:.|||.||:.:||:.|.....
Zfish   390 VSLKDLVEQRKTKLEQQYWLYQLKREVEALEKWISEREAVASSTELGQDLEHVTVLQSSFTQFSS 454

  Fly  1918 RVE-VGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHRF 1981
            ... ||..::|....:..::||.....|..:.:.::.|..||.:||:|:..|.|.|.|:.::|:|
Zfish   455 ETRAVGQKQMDSVNKMVNEMIDCSHSDAATIAEWKDGLNESWADLLELMETRAQMLAASYQLHKF 519

  Fly  1982 HRDVAEALFRIQDKNAALSQELGRDLNSAL--ALLRKHEGFENDLVALEAQLQVLVEDSVRLQAK 2044
            ..|..|.|.:|:.|...|.:.....::||.  .|.|....||:.|..|.:|::.|.|::|:|:|.
Zfish   520 FTDCQEVLVQIEGKMRQLPEVRSCQVSSANPGTLQRLLHSFEHSLQLLVSQVRQLQENAVQLRAI 584

  Fly  2045 YP-SNASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEE 2108
            |. ..|.||..::.:|:.||.:|.........::...:|...|...||::..|...:...:...:
Zfish   585 YAGEKADAILSREQEVMQAWKELLVACEGSRVQVTTVTDKIQFFAVVRELSMWMDGIMGQIGPND 649

  Fly  2109 HVSDAAGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAM------LD 2167
            ...|.:....:..||..:..::|.:...|.:..|:...::...:.||.:|:||...:      ::
Zfish   650 DARDLSVLEGMMSQHQNLKSKMENKSKNFVHCVEMGKMLLAARNPAAEEVKEKLEYVMAKQKEMN 714

  Fly  2168 ERQKLHAAWNKKKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALS-------------SSDFGQTV 2219
            ||..||  |.|              |:.|||  .|.|:|.....             :.:.|...
Zfish   715 ERWDLH--WEK--------------LQQAKQ--RLQSTQTGLTEQPWLTIKEPITPITREAGGGT 761

  Fly  2220 EDVQNKIRKHDEFERLIQTQEEKVSLLQEHGRKLIEQRHYDSANIQTILQGVLARRQKVKDLCAV 2284
            ::|:..||:|:.|.:...|.::..|.|:: ..|:.|:.:...:.      ..|..||.....|.|
Zfish   762 DEVEELIRRHEAFRKAASTWKDHFSSLRQ-AEKMKEELNKPPST------SSLLSRQMFPLSCLV 819

  Fly  2285 R------------RYKLEDALLYAKFVRD------------------------------------ 2301
            .            |..|:|:||.:|...|
Zfish   820 PSSSSSSSSSSLFRNPLQDSLLESKPGPDHMHSIEHTVTHTLPQRLGSSLNPYTPVMNGSSYHGL 884

  Fly  2302 ------CAEAKYWINEKQKKLEA-DAASY--------------AEVTNLDEKIKKLQKHQAFQAE 2345
                  ..|:..:.:.||:.:.: |.:||              :..|.|::        |...||
Zfish   885 QQPSGVVNESPLYQSIKQQGVSSLDNSSYKGLNQQVGVFGGNSSSYTGLNQ--------QGALAE 941

  Fly  2346 VAANQGRIQEIQDTGV----ILLSKQHESS----PEIK---RAIEIVLEAWQGLLA--------- 2390
            ..::...:..:...||    |..:.||..:    |:|.   :|:..:|||.:..||
Zfish   942 DGSSYHSLNHLGAVGVVEPKIGYAWQHLKADCFQPKINHIHKAVSPLLEAHRAQLASAGANMPAP 1006

  Fly  2391 ---------------ELEQRGRGLEEAQDSL----EF-----NSQLDKIEAWIRDKEMMVQASDT 2431
                           :.:.||...:...|.|    |:     .|...:|:|.:.:..::|:....
Zfish  1007 PVGMDPSLEMIHSRLQRDPRGSRSDPQMDHLRREREYRLGRQTSSEQEIQARLNELPLIVRQERY 1071

  Fly  2432 GRDLEHCNALMRKLDDVDSDMRVDDQRV-KHINQLADKLINQAQVPADTQSVDKRRKDFNYNWRQ 2495
            .|.:|..::..::..        ..||| ||.:..|:    ..:.|:|.:...::|.
Zfish  1072 RRRMERQSSSEQEAS--------GKQRVQKHDSSDAE----SGKEPSDKKPSGEKRS-------- 1116

  Fly  2496 LQGALNAYRALLGGANEIHVFNRDVDDTADRIAEKSLAMSSTDTGRDLAAVEALIRR-------- 2552
                                   .:.:..:::.|:....:..:..|..:::.|.:.|
Zfish  1117 -----------------------TMAEIVEQVQEREACHARGEVYRPASSLSAPVSRLDRPRARD 1158

  Fly  2553 ------------EEALERDMSAVKQKID----------QHETAAEFLIKKYPERGAQHIERKLEE 2595
                        .|...|..||..|.:.          .||   .||.:|:.|.|.:.....
Zfish  1159 RPKPRRRPRPKEPEEPRRSRSAPAQSVPSTPQPPTHTVHHE---GFLYRKHEEEGKERSPNS--- 1217

  Fly  2596 LHKSWGNLQALSVKRQS-------------------ILNEA---------YLAHKFV-------- 2624
              |||.||  ..|.:|.                   :||.|         |...|.|
Zfish  1218 --KSWVNL--FCVLKQGEIGFYKDARHTTTPYNDEPLLNLAICEFDTTNGYKKKKNVFILRTTAE 1278

  Fly  2625 -------SDVKELELWVNDM---------IKKMNNTQSPSTINDCETQLELHQERKVEIEGRQEA 2673
                   .|.::|:.|||.:         |.|.....:.||..|       ..|||...|| .|.
Zfish  1279 GDYIFLAKDEEDLKGWVNSINASLKEIEDIAKYEKATNSSTDPD-------KSERKERSEG-AEP 1335

  Fly  2674 FAGLKQQGEQLSKRPQQQQPDNVRKYLLVLEELHQTLNEAWSERARDLTE 2723
            ..|: ::.|:..|..:..:.|.:.            .::..||| ||.:|
Zfish  1336 SEGV-ERSERSEKSERSDRSDKIE------------ASDKSSER-RDASE 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kst	NP_001097492.2	CH_beta_spectrin_rpt1	61..176	CDD:409042
		CH_beta_spectrin_rpt2	196..302	CDD:409043
		SPEC	450..640	CDD:238103
		SPEC	658..832	CDD:238103
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103	24/76 (32%)
		SPEC	1449..1658	CDD:238103	45/193 (23%)
		SPEC	1555..1764	CDD:238103	52/218 (24%)
		SPEC	1765..1975	CDD:238103	67/211 (32%)
		SPEC	1873..2080	CDD:238103	63/210 (30%)
		SPEC	1979..2185	CDD:238103	52/214 (24%)
		SPEC	2188..2402	CDD:238103	56/330 (17%)
		SPEC	2407..2618	CDD:238103	42/274 (15%)
		SPEC	2514..2725	CDD:238103	55/292 (19%)
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103
		SPEC	3465..3680	CDD:238103
		PH_beta_spectrin	3801..3904	CDD:269975
sptbn4a	XP_073808197.1	None