Protein Alignment: Hsp83 and Hsp90b1

• Sequence 1: NP_001261362.1
• Gene: Hsp83
• FlyBaseID: FBgn0001233
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001012197.2
• Gene: Hsp90b1
• RGDID: 1310482
• Length: 804
• Species: Rattus norvegicus
• Alignment Length: 728
• Identity: 349/729 (48%)
• Similarity: 484/729 (66%)
• Gaps: 35/729 (5%)

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            |::|.||||||:.::|.||||:.|.|||||||||||||||||||||..||||.:.|...:||.:|
  Rat    71 EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVK 135

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFY 127
            :..::....|.:.|||:|||:.:||.||||||||||..|:    ||.:.|...| :|||||||||
  Rat   136 IKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFY 200

  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESKI 191
            ||:||||||.||||:|:|.|::|||.: ..|:|.|| ....|||||.|.|.:||:.:||||...|
  Rat   201 SAFLVADKVIVTSKHNNDTQHIWESDS-NEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTI 264

  Fly   192 KEIVNKHSQFIGYPIKLLVEKER--EKEVSDDE-ADDEKKEGDEKKEMETDEPKIEDVGEDEDAD 253
            |.:|.|:||||.:||.:...|..  |:.:.:|| |.:||:|.|       ||..:    |:|:.:
  Rat   265 KNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEAD-------DEAAV----EEEEEE 318

  Fly   254 KKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEG 318
            ||.|..|.:||:    .:.|.:|..||||.|...::.::||..||||.:.:.:|.:|..||:.||
  Rat   319 KKPKTKKVEKTV----WDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEG 379

  Fly   319 QLEFRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPL 381
            ::.|:::||:|...|..||:  ..||.:.||||||||||.|:..|::|:||||:||||||:||||
  Rat   380 EVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPL 444

  Fly   382 NISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLAD 446
            |:|||.|||:|:||||||.||:||:::|:::.::|.| ..|:.:|..|:||||.||.:||.:||.
  Rat   445 NVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAK 508

  Fly   447 FLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPID 511
            .|||.:|....|..||..||.|||:.|..:||:.|.|:.:..:|.||||:..:|:||:|:|||:|
  Rat   509 LLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVD 573

  Fly   512 EYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSN 575
            ||.||.|.|:.||:..:|.|||::..|.|..|:.||..:.:||.|...|| ..|.:|:||.|||.
  Rat   574 EYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQ 638

  Fly   576 RLVDSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADA 637
            ||.:|||.:|.||:|||.||||||||||.   :|.:|..|.:.||..||||.||::..:.::...
  Rat   639 RLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKE 703

  Fly   638 DKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPS 702
            |::||.|.||.::||||:.|.||:.|...:.:..||.||::|.|.||.:..:..:..:...|.
  Rat   704 DEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDT-- 766

  Fly   703 LVEDTEDASHMEE 715
             .|||.|.|..:|
  Rat   767 -TEDTTDDSEQDE 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	348/726 (48%)
		HATPase_c	28..179	CDD:214643	91/157 (58%)
		HSP90	184..706	CDD:278607	237/531 (45%)
Hsp90b1	NP_001012197.2	PRK05218	74..746	CDD:235366	338/689 (49%)
		HATPase_c	96..254	CDD:214643	93/159 (58%)
		HSP90	257..755	CDD:278607	235/514 (46%)
		Prevents secretion from ER. {ECO:0000255}	801..804

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D174605at33208
OrthoFinder	1	1.000				FOG0000421
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_126623
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810