Protein Alignment Hsp83 and Hsp90b1

DIOPT Version :10

• Sequence 1: NP_523899.1
• Gene: Hsp83 / 38389
• FlyBaseID: FBgn0001233
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001012197.2
• Gene: Hsp90b1 / 362862
• RGDID: 1310482
• Length: 804
• Species: Rattus norvegicus
• Alignment Length: 728
• Identity: 349/728 - (47%)
• Similarity: 484/728 - (66%)
• Gaps: 35/728 - (4%)

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            |::|.||||||:.::|.||||:.|.|||||||||||||||||||||..||||.:.|...:||.:|
  Rat    71 EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVK 135

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFY 127
            :..::....|.:.|||:|||:.:||.||||||||||..|:    ||.:.|...| :|||||||||
  Rat   136 IKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFY 200

  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESKI 191
            ||:||||||.||||:|:|.|::|||.: ..|:|.|| ....|||||.|.|.:||:.:||||...|
  Rat   201 SAFLVADKVIVTSKHNNDTQHIWESDS-NEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTI 264

  Fly   192 KEIVNKHSQFIGYPIKLLVEKER--EKEVSDDE-ADDEKKEGDEKKEMETDEPKIEDVGEDEDAD 253
            |.:|.|:||||.:||.:...|..  |:.:.:|| |.:||:|.|       ||..:    |:|:.:
  Rat   265 KNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEAD-------DEAAV----EEEEEE 318

  Fly   254 KKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEG 318
            ||.|..|.:||:    .:.|.:|..||||.|...::.::||..||||.:.:.:|.:|..||:.||
  Rat   319 KKPKTKKVEKTV----WDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEG 379

  Fly   319 QLEFRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPL 381
            ::.|:::||:|...|..||:  ..||.:.||||||||||.|:..|::|:||||:||||||:||||
  Rat   380 EVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPL 444

  Fly   382 NISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLAD 446
            |:|||.|||:|:||||||.||:||:::|:::.::|.| ..|:.:|..|:||||.||.:||.:||.
  Rat   445 NVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAK 508

  Fly   447 FLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPID 511
            .|||.:|....|..||..||.|||:.|..:||:.|.|:.:..:|.||||:..:|:||:|:|||:|
  Rat   509 LLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVD 573

  Fly   512 EYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSN 575
            ||.||.|.|:.||:..:|.|||::..|.|..|:.||..:.:||.|...|| ..|.:|:||.|||.
  Rat   574 EYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQ 638

  Fly   576 RLVDSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADA 637
            ||.:|||.:|.||:|||.||||||||||.   :|.:|..|.:.||..||||.||::..:.::...
  Rat   639 RLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKE 703

  Fly   638 DKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPS 702
            |::||.|.||.::||||:.|.||:.|...:.:..||.||::|.|.||.:..:..:..:...|.
  Rat   704 DEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDT-- 766

  Fly   703 LVEDTEDASHMEE 715
             .|||.|.|..:|
  Rat   767 -TEDTTDDSEQDE 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_523899.1	HSP90	6..717	CDD:481033	348/725 (48%)
Hsp90b1	NP_001012197.2	SRT pseudosubstrate motif. /evidence=ECO:0000250|UniProtKB:P14625	42..44
		HATPase_Hsp90-like	83..275	CDD:340404	109/192 (57%)
		HSP90	257..755	CDD:459703	235/513 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..323		14/45 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	749..804		9/33 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255	801..804