Protein Alignment Girdin and HOOK3

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_115786.1
• Gene: HOOK3 / 84376
• HGNCID: 23576
• Length: 718
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 172/730 - (23%)
• Similarity: 312/730 - (42%)
• Gaps: 169/730 - (23%)

  Fly    19 SIISWLESCLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLSIA-----RAK 78
            |:::|:::....|.... ...|.:|.::..|..:|||...:.    |.||.....:.     :..
Human    15 SLLTWIQTFNVDAPCQT-VEDLTNGVVMAQVLQKIDPAYFDE----NWLNRIKTEVGDNWRLKIS 74

  Fly    79 NFECVVRNLKSFFEEELGQTI--LVLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPNKELF 141
            |.:.:::.:..:..|.|||.|  ..|||...:|.|.::    .::..:|.|:||.||.|..|:.:
Human    75 NLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDA----AELGRMLQLILGCAVNCEQKQEY 135

  Fly   142 IARIKELDLETQHAIVGLIKQVTDSHSLV----------------LTEDSLERLTPQSMYTHILR 190
            |..|..::...||.::..|:::....|.|                .||:..|.|:.:.   .|.:
Human   136 IQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKE---EIAQ 197

  Fly   191 LTKERDVMYLKWIDLACVETEMTA--SDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAV 253
            ...|.|      :.:|.::.|.::  ::|.|       :....:...:...|:|.:.  ..||
Human   198 RCHELD------MQVAALQEEKSSLLAENQV-------LMERLNQSDSIEDPNSPAG--RRHL-- 245

  Fly   254 ECADLRSKNRKLRQELEEKSENLLELREELDDKKAR-------FDKLRQESQEWFTEAKRASAYR 311
                      :|:.:||:..|....|....||.:.|       ..:|||::.|..|.|..|.:.:
Human   246 ----------QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLK 300

  Fly   312 DEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEE--------- 367
            ||:|:||..:::..:||.:|:.|::||.|....:.:|:.|.|.|.:.:::...|||
Human   301 DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR 365

  Fly   368 -QLQRYRKR-----------SEHAISLESEIIKYKQKINDMALERD---VDRSKLEELLEE---- 413
             ||:.|:::           |:.|..|:.|..:.|:|::.:..|:|   .:|..|:|.:||
Human   366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCV 430

  Fly   414 -NSQLQLVARNL-------------------------------NSTMDLDKSFSENEDDCNSGDN 446
             ..:.||..:.|                               |..:.|::..|:||      ..
Human   431 QAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNE------KI 489

  Fly   447 SLSEQLTNNAQTRALKLELENR----RLTAALEQLKE--SSFHESTSKMLELEKEKKKLSLKIEQ 505
            :|.:.|.::|..|..:||.|||    ||.....|::|  .|..:..||..:....||||...:|:
Human   490 ALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554

  Fly   506 MQENINRLTQQNV---ELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDAEQHVE 567
            :.|..|.|.::..   :||..|.|:..:.::||:|:  |:|..:.:.:| |..::.|..|:..:.
Human   555 LHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEAL--RKKEEEMKQME-ERYKKYLEKAKSVIR 616

  Fly   568 TLN-KEKQ----RIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELTK-QKLYEIEARVS 626
            ||: |:.|    .||.|...:|.|    :||..|..||          ||.|| |:..|.:..||
Human   617 TLDPKQNQGAAPEIQALKNQLQER----DRLFHSLEKE----------YEKTKSQREMEEKYIVS 667

  Fly   627 TYERENASLLKEVSK 641
            .:.....:|.|:.::
Human   668 AWYNMGMTLHKKAAE 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	36/152 (24%)
		SMC_prok_B	315..1110	CDD:274008	102/402 (25%)
HOOK3	NP_115786.1	Sufficient for interaction with microtubules	1..164		37/157 (24%)
		HkD_Hook3	8..160	CDD:411797	36/153 (24%)
		HOOK	184..709	CDD:461694	132/552 (24%)
		Required for association with Golgi	553..718		41/147 (28%)
		Required for interaction with MSR1. /evidence=ECO:0000269|PubMed:17237231	556..718		40/144 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..718		0/1 (0%)