Protein Alignment Girdin and Ccdc88c

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_080957.2
• Gene: Ccdc88c / 68339
• MGIID: 1915589
• Length: 2009
• Species: Mus musculus
• Alignment Length: 1691
• Identity: 449/1691 - (26%)
• Similarity: 736/1691 - (43%)
• Gaps: 424/1691 - (25%)

  Fly    12 IDEFVNSSIISWLESC----LPRAELLAGYTSLLDGHIIHSVWLQIDPEPQN---NPSELNDLNG 69
            ::.|:.|.:::|:::.    ....:.|..|..|:||..::.:.|||||.|.|   |....||:|
Mouse     9 VELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVN- 72

  Fly    70 KSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
                 .|.:|...:|||:|::::|.|.|.|:: ||:...:|..|.|...:|::|.:|.|:||.||
Mouse    73 -----LRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAV 132

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLV----------LTEDSLERLTPQSMYTHI 188
            ||..||.||.|||:||:|||..||..|::||.:...|          :..:.||.|: ::|..|:
Mouse   133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALS-RNMVFHL 196

  Fly   189 LRLTKERDVMYLKWIDLACVE--TEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHL 251
            .||..|||         .|.|  .::|...:.::..|..|..:..|..:..|..||.|:.:..||
Mouse   197 RRLIDERD---------ECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHL 252

  Fly   252 AVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDI 316
            |||.||.:::.|::|||||||:|.|.:.|.|:|.......|.:|::.:...:|:.|.|||||:|.
Mouse   253 AVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDS 317

  Fly   317 LRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAIS 381
            |||:|.|.:|||:::.:.:|||.|.||||:|:|||||||.:|:|:|.||||||...|.||:....
Mouse   318 LREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHE 382

  Fly   382 LESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVAR-NLNSTMDLD---KSFSENEDDCN 442
            ||.|.::.|.|::|:.|:||.|:.::|:||||...|::..: ::..:..|.   :..|:|.|..:
Mouse   383 LEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSD 447

  Fly   443 SGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESS--FHESTSKMLELEKEKKKLSLKIEQ 505
            :...|...:|...|.:|.||||.||:.|.:.::.|:::|  ..||:.|..|||||.::||.|||:
Mouse   448 ASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEK 512

  Fly   506 MQENINRLTQQNVELEGVFKNALEENKKLQDAV-------------------------------- 538
            :|..:.|..|.|.:||.:.:..:.|.::||..:
Mouse   513 LQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERP 577

  Fly   539 ----------DNR--------------QKSYDRQSLEREADRQK--------------------- 558
                      :||              |...::|.|.|:.:..|
Mouse   578 QVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENE 642

  Fly   559 --------LSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLA--------------------- 594
                    |..|.:.||.|..:.|.::..|.|:::..|.|:.::
Mouse   643 QLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELR 707

  Fly   595 ----------------ESKTKELEQYLE--------------KSRQYELTKQ------------- 616
                            |::.::||:..|              ||.:.||:.|
Mouse   708 KMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSL 772

  Fly   617 ------------KLYEIEA-------------------------------RVSTYERENASLLKE 638
                        :|.::||                               .|:..|::...|.||
Mouse   773 ESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKE 837

  Fly   639 VSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRIIDQE 703
            ..:|.:..|.|...||||..:|....||.:.|.|.|.....|..||.||||.|::|..|..:...
Mouse   838 ARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTR 902

  Fly   704 MISTLRNDLVTGTLVTK-------KVRNNLEKLGLA-------DEEPGE--------------LN 740
            .::|||.|||...|.::       |:...|||:||:       |:..|:              :.
Mouse   903 TLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMK 967

  Fly   741 VEHVV--EKLVRNPETFKTVREIMLNVTREQLEE--EEREGGVKSDMC-------VLCHRQ---- 790
            .|.:|  |..|...|:.....:|.|.:.:::.|:  :.:|||.|:...       |..|::
Mouse   968 EEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAW 1032

  Fly   791 ---------EIFTV-EKNIELAATPAPAPAQP----------SSQELRFEHKVRLSPARESAELT 835
                     |:..| ::.|||..:.|...|:.          .:|.:.|..:: |:..::||.|
Mouse  1033 EPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQI-LTLQKQSAFL- 1095

  Fly   836 RIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQEHKHA 900
              ::..|.|||:.|:|.|:.:.|.||..:|:.|:..||...:...||.:.|.::.:.|...::..
Mouse  1096 --QEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEAL 1158

  Fly   901 LQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSALEQRIEELTIQNSNMKT 965
            |||...|..|::..|:|||:|.:....||...|:|..|.::..|:...|:||..||
Mouse  1159 LQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAEL--------- 1214

  Fly   966 CSEDL-SILRTEHSKLTDDFR-NLFATSD--RFKNEYKNIQEQYKMVRMEHSSLKLQNTELSGEL 1026
              |:| .:|.||...|..:.: |..|||:  |.:.|...|...::.::.|:..|.....||...|
Mouse  1215 --EELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSL 1277

  Fly  1027 NAK--------------SDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQE 1077
            |..              .:|.:.:.:..:|:...||:|.:....|:.|...|:..:..|..|.|.
Mouse  1278 NNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1342

  Fly  1078 LLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPF--ASMLVRRVK 1140
            ||..::|.|:.:|||:|.|.:::::|:|.|||||||||:.||..:....||..:  |..||:.:|
Mouse  1343 LLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHWIGAKALVKLIK 1407

  Fly  1141 KAS--------------------SDLMNKVPSRNRRS-------------WVDDARTNSQFV--- 1169
            ...                    ||..:..||:..||             .|::..|::..|
Mouse  1408 PKKEGSRERLKSTTDSPPWQLEPSDPASPSPSQALRSQTENPDNPPSGPNCVEERDTHNGPVGKG 1472

  Fly  1170 -------IGSESGG--NESDNSNE--------EP----LSIASDTHLLQRNVPLRQSLQR----- 1208
                   .||..||  :.:|.|.:        ||    .|.::.|..|..:.|:.:.|.|
Mouse  1473 PGDLKPKRGSPRGGSVDRTDTSTDPAVKSWPSEPGSRTFSTSATTAALSSSTPIPKHLGRTKGCN 1537

  Fly  1209 ---DLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAP-DVTGSS--------------- 1254
               :|.:.|.:..|..... ||.:...|.:||..|.:.|   | .:.|||
Mouse  1538 SDDNLCEPSSEPDGPYHRQ-QASRPNSLESSRNASSNSS---PLSLKGSSDHLHSRCESFSSADL 1598

  Fly  1255 ------LTLGTAGSRRTVYLIDEHQKLPDGSTPGATQS-QSVGGSGSVNAAPPTPAEPQTPQKST 1312
                  .||...|:.....|:..|:..|..:.|.:.:: |..|.:.:.....|..|.|.:...:.
Mouse  1599 IPSRDPATLSRDGNTSGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVTL 1663

  Fly  1313 E 1313
            |
Mouse  1664 E 1664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	60/157 (38%)
		SMC_prok_B	315..1110	CDD:274008	273/1073 (25%)
Ccdc88c	NP_080957.2	HkD_Daple	12..164	CDD:411799	60/157 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..251		7/29 (24%)
		SMC_prok_B	<267..627	CDD:274008	120/359 (33%)
		SMC_prok_B	489..1307	CDD:274008	180/832 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1002..1036		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1410..1716		50/259 (19%)
		PHA03307	1625..>2001	CDD:223039	8/40 (20%)
		GBA. /evidence=ECO:0000250|UniProtKB:Q9P219	1652..1683		3/13 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1757..1787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1808..2009
		PDZ-binding. /evidence=ECO:0000255	2006..2009
		DVL1-binding. /evidence=ECO:0000269|PubMed:14750955	2007..2009