Protein Alignment Girdin and Ccdc88c

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_001419013.1
• Gene: Ccdc88c / 362770
• RGDID: 1307429
• Length: 2012
• Species: Rattus norvegicus
• Alignment Length: 1655
• Identity: 442/1655 - (26%)
• Similarity: 730/1655 - (44%)
• Gaps: 386/1655 - (23%)

  Fly    12 IDEFVNSSIISWLESCLP----RAELLAGYTSLLDGHIIHSVWLQIDPEPQN---NPSELNDLNG 69
            ::.|:.|.:::|:::..|    ..:.|..|..|:||..::.:.|||||.|.|   |....||:|
  Rat     9 VELFLQSPLVTWVKTFGPFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVN- 72

  Fly    70 KSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
                 .|.:|...:|||:|::::|.|.|.|:: ||:...:|..|.|...:|::|.:|.|:||.||
  Rat    73 -----LRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAV 132

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLV----------LTEDSLERLTPQSMYTHI 188
            ||..||.||.|||:||:|||..||..|::||.:...|          :..:.||.|: ::|..|:
  Rat   133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALS-RNMVFHL 196

  Fly   189 LRLTKERDVMYLKWIDLACVE--TEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHL 251
            .||..|||         .|.|  .::|...:.::.....|..:..|..:..|..||.|:.:..||
  Rat   197 RRLIDERD---------ECTELIVDLTQERDYLQAQHPPSPGKFSSPDSTPSPTSSLSSEDKQHL 252

  Fly   252 AVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDI 316
            |||.||.:::.|::|||||||:|.|.:.|.|:|.......|.:|::.:...:|:.|.|||||:|.
  Rat   253 AVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDS 317

  Fly   317 LRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAIS 381
            |||:|.|.:|||:|:.:.:|||.|.||||:|:|||||||.:|:|:|.||||||...|.||:....
  Rat   318 LREKANRVERLEMELVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHE 382

  Fly   382 LESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVAR-NLNSTMDLD---KSFSENEDDCN 442
            ||.|.::.|.|::|:.|:||.|:.::|||||||..|::..: ::|.:..|.   :..|:|.|..:
  Rat   383 LEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSD 447

  Fly   443 SGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESS--FHESTSKMLELEKEKKKLSLKIEQ 505
            :...|...:|...|.:|.||||.||:.|.:.::.|:::|  ..||:.|..|||||.::||.|||:
  Rat   448 ASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLALEESSLKCGELEKENQQLSKKIEK 512

  Fly   506 MQENINRLTQQNVELEGV----------------------------------------------- 523
            :|..:.|..|.|.:||.:
  Rat   513 LQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERP 577

  Fly   524 ----FKNALEENKKLQDAV------------DNRQKSYDRQSLEREADRQKLSDAEQH------- 565
                .|:..:||:.|..||            :.:|...|.:..:.:.:|.::.:.|.|
  Rat   578 QVNSMKDVEKENRTLHQAVTEAGSKLSQLESEKKQLHRDLEEAKEKGERAEVLEKELHRLEKENE 642

  Fly   566 ---------------VETLNKEKQRIQTLNESIQRRADDLERLA------ESKTKELEQYLEKSR 609
                           ||.|..|.|.::..|.::::..|.|:.::      |...|:|:|...:.|
  Rat   643 QLTKKVTSLKTVTEKVEALEHESQGLELENRTLRKSLDTLQNVSVQLEGLERDNKQLDQENRELR 707

  Fly   610 Q----YELTKQKLYEIEARVSTYERE------NASLLKEVSK----------------------- 641
            :    ...|..|:.::|......|||      |..:||.:||
  Rat   708 KMVEAMRFTSAKMAQMETENQQLEREKEELRRNVEMLKTLSKKSERLEHSYQSVSAENLQLQHSL 772

  Fly   642 -----------------------LK-------------EGSEQ---------------------- 648
                                   ||             ||:|:
  Rat   773 ESSNHKSQALQRELSELEAERQALKRDLETLQLANKQLEGAEKDRKALEQEVAQLEKDKKLLEKE 837

  Fly   649 ----------KSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRIIDQE 703
                      |...||||..:|....||.:.|.|.|........||.||||.|::|..|..:...
  Rat   838 TRRLWQQVELKDAVLDDSAAKLSAAEKESRALDKELARCRDAASKLKELEKDNRDLTKQVTVHTR 902

  Fly   704 MISTLRNDLVTGTLVTK-------KVRNNLEKLGLA-------DEEPGE---------------- 738
            .::|||.|||...|.::       |:...|||:||:       |...|:
  Rat   903 TLTTLREDLVLEKLKSQQLTSELDKLSQELEKVGLSKELLLQEDNSHGDTKGKIWESKNESSLKT 967

  Fly   739 ---LNVEHVV--EKLVRNPETFKTVREIMLNVTREQLEE--EEREGGVKSDMC-------VLCHR 789
               :..|.:|  |..|...|:.....:|.|.:.:::.|:  :.:|.|.::...       |..|:
  Rat   968 TLAMKEEKIVFLEAQVEEKESLNHQLQIELQMVKKECEQLRKTQEDGTQAQNVQKHAPDKVTSHQ 1032

  Fly   790 Q-------------EIFTV-EKNIELAATPAPAPAQP----------SSQELRFEHKVRLSPARE 830
            :             |:..| ::.|||..:.|...|:.          .:|.:.|..:: |:..::
  Rat  1033 EKEAWGPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQI-LTLQKQ 1096

  Fly   831 SAELTRIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQ 895
            ||.|   ::..|.|||:.|:|.|:.:.|.||..:|:.|:..||..::...||.:||.::.:.|..
  Rat  1097 SAFL---QEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTMLQSQHAAKEAEHESLQQQQEELAA 1158

  Fly   896 EHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSALEQRIEELTIQN 960
            .::..|:|...|..|:::.|:|||:|......||...|:|..|.::..|:...|::|..||....
  Rat  1159 VYEALLRDHDRLGALYERQSSEYEALICQHSCLKTLHRNLELEHKELGERHGDLQKRKAELEELE 1223

  Fly   961 SNMKTCSEDL-------SILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVRMEHSSLKLQ 1018
            ..:.|..|.|       :|..:|:.:|..:...:.....:.|.||:.:....|.::...::.:|:
  Rat  1224 KALSTEREVLQQEQRTSAIATSENQRLRGELDRISFLHHQLKGEYEELHAHTKELKTSLNNSRLE 1288

  Fly  1019 NTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQELLAISL 1083
            ........:...:|.:.:.:..:|:...||:|.:....|:.|.:.|:..:..|..|.|.||..::
  Rat  1289 LNRWQARFDELKEQHQNMDISLTKLDNHCELLSRLKGNLEEENQHLLSQIQLLSQQNQMLLEQNI 1353

  Fly  1084 EDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPF--ASMLVRRVKKASSDL 1146
            |.|:.:|||:|.|.:::::|:|.|||||||||:.||..:....||..:  |..||:.:|......
  Rat  1354 ESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHWIGAKALVKLIKPKKEGS 1418

  Fly  1147 MNKVPSRNRRSW----VDDARTNSQFVI--GSESGGNESDNSN--EEPLSIASDTHLLQRNVPLR 1203
            ..::.|.:...|    .|.|...:...:  .:|:..|....||  ||     .|||    |.|:.
  Rat  1419 RERLKSSDSPPWQLESSDPASPPASQTLRPQTENSDNPPSGSNCTEE-----RDTH----NGPVG 1474

  Fly  1204 QSLQRDLL-DNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEA-PDVTGSSLTLGTAGSRRTV 1266
            :. ..||. .....|||.|       .|||      .|...:::: |...||. :..|:.:...:
  Rat  1475 KG-PGDLKPKRGSPRGGTV-------DRTD------TSTDPAVKSWPSEPGSR-SFSTSATTAAL 1524

  Fly  1267 YLIDEHQKLPDGSTP-----GATQSQSVGGSGSVNAAPPTPAEPQTPQKSTENNAPVGPATFLMY 1326
                      ..|||     |.|:    |.:...|...|:| ||:.|....:.:.|
  Rat  1525 ----------SSSTPILKHLGRTK----GCNSDDNLCEPSP-EPEGPYHRQQVSRP--------- 1565

  Fly  1327 NRINTTIGGASNSGDQSPLLQASGSVSGTT 1356
               |:.....|.|.:.|||     |:.|::
  Rat  1566 ---NSLESSRSTSSNSSPL-----SLKGSS 1587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	61/157 (39%)
		SMC_prok_B	315..1110	CDD:274008	266/1067 (25%)
Ccdc88c	NP_001419013.1	HkD_Daple	12..164	CDD:411799	61/157 (39%)
		Smc	<247..>714	CDD:440809	146/466 (31%)
		SMC_prok_B	508..1384	CDD:274008	186/879 (21%)
		PHA03247	<1412..2002	CDD:223021	51/232 (22%)