Protein Alignment Girdin and Ccdc88b

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_001419085.1
• Gene: Ccdc88b / 293698
• RGDID: 1311475
• Length: 1476
• Species: Rattus norvegicus
• Alignment Length: 1602
• Identity: 368/1602 - (22%)
• Similarity: 634/1602 - (39%)
• Gaps: 394/1602 - (24%)

  Fly    14 EFVNSSIISW---LESCLPRAELLAG------------------YTSLLDGHIIHSVWLQIDPEP 57
            :|::.|:.:|   |...:..||..:|                  :..|:.|.::..|...|.|..
  Rat    11 DFLSGSLATWALGLAGLVGEAEESSGTEEEEEEEEEGPLCTERRFLKLISGDLLLRVLGIIAPSS 75

  Fly    58 QNNPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILVL---PDAFTLGHHPESKNGLE 119
            :.....:...:|.  :..|..|...:...|:.|::|||  .:|:|   ||..|||..|.|:..::
  Rat    76 RGRLQMVKGHDGP--AACRIWNLYHLWGRLRDFYQEEL--QLLILSPPPDLQTLGFDPFSEEAVD 136

  Fly   120 QMKTLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTD-----------SHSLVLTE 173
            :::.:|.|||||:|||.::||||..|:.|.|:.|..:...|::||.           ..|..|..
  Rat   137 ELEGILRLLLGASVQCEHRELFIRHIQGLSLDVQSELAAAIQEVTQPGAGVVLALTGPESAELVA 201

  Fly   174 DSLERLTPQSMYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATS 238
            :.||......|.| :.||.:|||:                .:..|.|    |.:.|.|::   ..
  Rat   202 EELEMQLRNLMGT-MSRLVRERDL----------------GAQRLAE----VLLEREPAH---LL 242

  Fly   239 TPSSSSNSE----SNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQE 299
            .|.:|:|:.    |:|||::..:.:::.|:||||:|||:|.||:.:.|:...::...:||||:|.
  Rat   243 LPEASANASAEGPSHHLALQLTNAKAQLRRLRQEVEEKAELLLDSQAEVQGLESEIRRLRQETQA 307

  Fly   300 WFTEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEM 364
            ...:||||..||:|.:.|||||.|..||:.|:::.||:|..::.:|.::||.|..:..|..||.:
  Rat   308 LSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLHAAEVFKGQLEEERVLSGALEASKVL 372

  Fly   365 LEEQLQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTMD 429
            |||||:..|:||......:.|.:..:.::.:...:.|..|.:||:|:|||.:|:|         :
  Rat   373 LEEQLEIARERSARLHETQRENLLLRTRLGEAHADLDSLRHQLEQLVEENVELEL---------E 428

  Fly   430 LDKSF-----SENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKES-----SFHE 484
            |.:|.     |..|........||.:::......|...:|.|||.|...|:.|:|.     ...|
  Rat   429 LQRSLEPPPGSPGETSLPGAAPSLQDEVREAEAGRLRTVEQENRTLRGQLQMLREQLDSQRPLLE 493

  Fly   485 STSK-------------MLELEKEKKKLSLKI------------EQMQENINRLTQ------QNV 518
            ..||             .|.|:...|.|:.:|            ......|.||::      .:.
  Rat   494 EQSKDSMLPVTNGAPAAPLALDHSPKSLACQIGGEGPGSLDLPSPASYSGITRLSECLQAPDSHP 558

  Fly   519 ELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLS-----DAEQHVETLNKEKQRIQT 578
            ||:..|:...::.:......::.......||||:...|..:.     |..|..|.    :..:|.
  Rat   559 ELDSPFQMVSQDPQTSDQTQESDPTGEAHQSLEKSGHRVSVQSPIVWDPPQGAEI----RIDVQE 619

  Fly   579 LNESIQRRADDLERLAESKT------------------------KELEQYLEKSRQY-------- 611
            |.|:..|.|.:.|.:.|::.                        |.||..||.|:|.
  Rat   620 LGETGSREASEGESVPEAQVLKQENPECRPRSAEFILLEPLKDQKTLEPELELSKQQTETGGHEQ 684

  Fly   612 -------ELTKQKLYEI-EARVSTYER--------------ENASLLKEVSKLKEGSEQKSVQLD 654
                   :|..||..:. |.....:.|              |..:|..||::|:........:|.
  Rat   685 RPKGLVNKLVLQKPQQTSEGPPDAWSREEPIPGETLATAIPEEQALRDEVAQLRREVVSLEAKLQ 749

  Fly   655 DSINRLDVQSKELQKLGKALEDSEQVHQKL-VELEKQNQELASQR------IIDQEMISTLRNDL 712
            ....||:.:|.|...|.:.|..:.:...:. :|:|.:.:|.|..|      .::.|..|..|..|
  Rat   750 AQAQRLEARSAEAVSLSEELAQARRTEAEAHLEVEARAREQARLREAVDAASLELEAASREREAL 814

  Fly   713 VTGTLVTKKVRNNLEKLG---LADEEPGELNVEHVVEKLVRNPETFKTVREIMLNVTREQLEEEE 774
            ........:.|...|:.|   .|..|..|..|: .:|..||..........:.....||:||:..
  Rat   815 AEALAAAGRERRQWEREGPRLRAQVEAAEQQVQ-ALESQVRCHLEEAEREHLEKQALREELEKAV 878

  Fly   775 REGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPAQP-SSQELRFEH-----KVRLSPARESAE 833
            ..|....|.  |.|      :::.:|.||.......|. .||..|::|     :..|..|..:.|
  Rat   879 VRGQELGDR--LEH------LQRELEQAALERQKFLQERESQHQRYQHLEQRLEAELQAASTNKE 935

  Fly   834 --LTRIKDSNTQLQTENARL-------SVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKE 889
              |.::|....||:.|..:|       :.:|.|....:.:.|.:.:.::..|:.|.|||.:|..:
  Rat   936 EALMKLKARALQLEEELIQLRQYPVDQATEVRAEPRTVETQNGRLIEVERNNATLVAEKAALQGQ 1000

  Fly   890 IDSLQ--------------------QEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRD 934
            :..|:                    |||...||.:.::      :..:.:.|::....|:..||.
  Rat  1001 LQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSM------MEIQGQELHRKLGVLEEEVRV 1059

  Fly   935 LRQELRDTREQQSAL--------------EQRIEELTIQNSNMKTCSEDLSI----LRTEHSKLT 981
            .|:...:||.||.||              |..:|.|.:::.::|.....|.:    |:..|.:|.
  Rat  1060 ARRAQEETRGQQQALLRDHEALVQLQRRQETELEGLLVRHRDLKANMRALELAHRELQGRHEQLQ 1124

  Fly   982 DDFRN-------LFATSDRFKNE---YKNIQEQYKMVRMEHSSLKLQNTELS---GELNAKSDQV 1033
            ....:       |.|..:|...:   .:.::|:.:.::.||...::...|:|   |||..:..::
  Rat  1125 AQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQNEHDRAQMLLAEVSRERGELQGERGEL 1189

  Fly  1034 RC-----------LQMEYSKVQQ--------------RCEMLIQNNAELDSERKALMDNVSQLLS 1073
            |.           |:::..|:::              :||:|.|..:..:.|.:.|:..|..|..
  Rat  1190 RSRLARLELERAQLEIQSQKLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSR 1254

  Fly  1074 QYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPFASMLVRR 1138
            :.:|||..|||.:.|.|.|::.|.:::::|:|:|:||.||||:.|:..|.....:....|.|..:
  Rat  1255 ENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPGPLPRTKKGSWLADK 1319

  Fly  1139 VKKASSDLMNKVPSRNRRSWVDDARTNSQFVIGSESGGNESDNSNEEPLSIASDTHLLQRNVPLR 1203
            ||:.         .|.||.             |:..||..          :.:|
  Rat  1320 VKRL---------IRPRRE-------------GALHGGPR----------LGAD----------- 1341

  Fly  1204 QSLQRDLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAPDVTGSSLTLGTAGSRRTVYL 1268
                          |.....||.....|:|...|        || |.||||.......::.::.|
  Rat  1342 --------------GAGSTESLGGPLETELPEGR--------EA-DGTGSSSPAPMRRAQSSLCL 1383

  Fly  1269 IDEHQKLPDGSTPGATQSQSVGGSGSVNAAPPTPAEPQTPQKSTENNAPVGPATFLMYNRINTTI 1333
            .||:..   |.......|:...|..|.:.:|     ..||::......| ||.
  Rat  1384 GDENLA---GGQRRRLSSRFPAGRSSASFSP-----GDTPRQRFRQRRP-GPL------------ 1427

  Fly  1334 GGASNSGDQSPLLQASGSV----------SGTTMQDDKSARK 1365
             ||.:|..:...::..||:          :|..:|:.|..::
  Rat  1428 -GAPSSHSKGSGVEWDGSIETLSEHEADATGEALQEQKPEKQ 1468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	48/173 (28%)
		SMC_prok_B	315..1110	CDD:274008	219/995 (22%)
Ccdc88b	NP_001419085.1	HkD_Gipie	10..182	CDD:411801	48/174 (28%)
		SMC_prok_B	<262..955	CDD:274008	173/714 (24%)
		Smc	<728..>1297	CDD:440809	129/583 (22%)