Protein Alignment Girdin and Hook2

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: XP_036009672.1
• Gene: Hook2 / 170833
• MGIID: 2181664
• Length: 833
• Species: Mus musculus
• Alignment Length: 758
• Identity: 163/758 - (21%)
• Similarity: 300/758 - (39%)
• Gaps: 192/758 - (25%)

  Fly    27 CLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNP--SELNDLNGKSLSIARAKNFECVVRNLKS 89
            |....:|.:|   |...|:::    ||||...||.  ..:::.:..|..: :.:..|.::::|..
Mouse    76 CASPQDLSSG---LAIAHVLN----QIDPSWFNNEWLQGISEDSSPSWRL-KVRKLEKILQSLVE 132

  Fly    90 FFEEELGQTI--LVLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPNKELFIARIKELDLET 152
            :.:..||..:  ..|||...:|   |..|..|..| ||.|:||.|:.|..|:.:|.||..|:...
Mouse   133 YSKNVLGHPVSDQHLPDVSLIG---EFSNPAELGK-LLQLVLGCAISCEKKQEYIQRIMTLEESV 193

  Fly   153 QHAIVGLIKQVTDSHSLVLTEDSLERLTPQS---------MYTHILRLTKERDVMYLKWIDLACV 208
            ||.::..|::       ::|:|:.:.|:|::         .|..:....:|.|.:...::||
Mouse   194 QHVVMEAIQE-------LMTKDTPDSLSPENYGNFDTQSRRYYFLSEEVEEGDHLQQHYLDL--- 248

  Fly   209 ETEM----TASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADLRSKNRKLRQEL 269
            |.::    ....||.:  :..::..........|.|..:: .:...|..:...|:.:|.:|....
Mouse   249 ERQLLLLSEEKQNLAQ--ENAALRERVGRSEVESAPGLTA-KKLLLLQSQLEQLQEENFRLESSR 310

  Fly   270 EEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRERAERADRLEVEVQKY 334
            |:.....|||..|:.:.:.|...|...|||       |.|.:||:|.||:.:|||.:||..:...
Mouse   311 EDDRLRCLELEREVAELQQRNQALTSLSQE-------AQALKDEMDELRQSSERARQLEATLNSC 368

  Fly   335 REKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLESEIIKYKQKINDMALE 399
            |.:||:....:.:|.:|.|.|....|....|||:|:|       |.||.:::...::::.::..:
Mouse   369 RRRLGELQELRRQVRQLEERNAGHAERTRQLEEELRR-------AGSLRAQLEAQRRQVQELQGQ 426

  Fly   400 RDVDRSKLEELLEENSQLQLVARNLNSTMDL------------DKSFSENE-------------- 438
            ...:..|.|:.|.|       .|||....||            |.....||
Mouse   427 WQEEAMKAEKWLFE-------CRNLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQ 484

  Fly   439 -----DDCNSG-DNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKK 497
                 |...|| :|..:|.|....:...::|:|||:||  ..::..:....|...:.|| |..:.
Mouse   485 ADLSLDPTPSGLENLAAEILPAELRETLVRLQLENKRL--CQQEAADRERQEELQRHLE-EANRA 546

  Fly   498 KLSLKIEQMQENINRLTQQNVELEGVFKNALEENKKLQD-------------------------- 536
            :..|:.:| :.|..:|::...::|.:.|...|:..|.:|
Mouse   547 RHGLEAQQ-RLNQQQLSELRAQVEELQKALQEQGGKTEDVSACLLPAWPSLVLPSNPPFSLPPCC 610

  Fly   537 ----------------------------------AVDNRQKSYDRQSLEREADRQKLSDAE---- 563
                                              |....|.:..::.||...  |||.:|:
Mouse   611 PMPEEGHCEYHGSREAHHCYLHSFSDLVPVPSLPAASLPQPTLLKRKLEDHL--QKLHEADLELQ 673

  Fly   564 ---QHVETL-----NKEKQRIQTLNESIQRRADDLERLAE------SKTKELEQYLEK------- 607
               :::|.|     :...:||:.|.:|:|::..||..:.|      .|.:.:.|.||.
Mouse   674 RKREYIEELEPPTDSSTARRIEELQDSLQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTV 738

  Fly   608 -SRQYELTKQKLYEIEARVSTYERENASLLKEVSKLKEGSEQK 649
             |.::...:.:|:|...|:...|.:     .|.|:.::..|:|
Mouse   739 VSPEFHTLRSQLWERNLRIRQMEMD-----YEKSRRRQEQEEK 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	39/141 (28%)
		SMC_prok_B	315..1110	CDD:274008	92/453 (20%)
Hook2	XP_036009672.1	HkD_SF	67..207	CDD:425405	39/149 (26%)
		HOOK	230..819	CDD:461694	119/585 (20%)