Protein Alignment Girdin and hook2

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: XP_002938530.1
• Gene: hook2 / 100497596
• XenbaseID: XB-GENE-991660
• Length: 721
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 166/807 - (20%)
• Similarity: 314/807 - (38%)
• Gaps: 240/807 - (29%)

  Fly    19 SIISWLES------CLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLSIARA 77
            |:::|:::      |       :.|..|..|..|..|..:||      ||..|:.....:.....
 Frog    12 SLLTWMQTFQVSGPC-------SSYEDLTGGVAIAQVLNRID------PSWFNEAWLVRVKQDTT 63

  Fly    78 KNFECVVRNLK-------SFFEEELGQTIL--VLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
            :|:...|.|||       .::::.||..:.  .:||...:|   |..|..| ::.::.|:||.|:
 Frog    64 ENWRIKVSNLKRILQSILEYYQDVLGHPVSDDHIPDVALIG---EFSNAAE-LRKMVQLVLGCAI 124

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLERLTPQSMYTHILRLTKERDVM 198
            .|..||..|.:|..|....|.|::..|::       :|::|..:.:|.:|   :|...::.|...
 Frog   125 SCDKKEEHIQQIMTLGESVQQAVMESIQE-------LLSKDPTDAVTSES---YINYDSQSRKYY 179

  Fly   199 YLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADLR---- 259
            :|                                         |..|.|.|.:...|.||.
 Frog   180 FL-----------------------------------------SEDNDEKNEILQRCHDLEQQVS 203

  Fly   260 ----------SKNRKLRQELEEK--------SENLLELREEL--------------DDKKAR--- 289
                      .:||.||::.|:.        ::.||.|:.::              ||.:.|
 Frog   204 LLMEEKKNLVGENRNLREQQEQSGMGTPQLFNKKLLLLQSQIEQLQEENYRLESSRDDYRQRCQE 268

  Fly   290 ----FDKLRQESQEWFTEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEE 350
                ..:|:|.:|:....|..|.|.|||:|:||..::|..:||..|:.|::||.|....:.:|:.
 Frog   269 LDRDIQELQQRNQDLTGLAHEAQALRDEMDVLRHSSDRVGKLESLVESYKKKLEDLGDLRRQVKL 333

  Fly   351 LREDNRVLLESKEMLEEQLQR------------------YRKRSEHAISLES---EIIKYKQKIN 394
            |.|.|.|.::....|||:|.:                  ::|.|..::..|.   |....|:|..
 Frog   334 LEERNTVYMQRTCQLEEELHKANASRGQLENLSRQIQELHKKHSTESLRAEKWQFEFQTLKEKFE 398

  Fly   395 DMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENEDDCNSG-----DNSLSEQLTN 454
            .:..||:...::.:.|.|.|.:|:        ...|.::.....|...||     :|..:|.:..
 Frog   399 ALQKERERLITERDSLRETNDELR--------CSHLQQTCLGQADVLLSGSSPPLENLAAEIVPA 455

  Fly   455 NAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKKKLSLKIEQMQENINRLTQQNVE 519
            ..:...::|:.||:.|..     :|:|:.:....:..|.:|    |.:.:...|:.:||.||.:
 Frog   456 ELRETVMRLQQENKMLCT-----QEASYQDRLCDLQNLLEE----SNRSKNRMESESRLQQQQI- 510

  Fly   520 LEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDAEQHVETLN-------KEKQRIQ 577
                        |:|:..|:..||....|....|...|.....|:|:|.|:       |:::.|:
 Frog   511 ------------KELKAQVEELQKHLREQGNRAEDSSQLKRKLEEHLEMLHDAHSELQKKREYIE 563

  Fly   578 TLNE----SIQRRADDLERLAESKTKEL-------EQYLEKSR----------------QYELTK 615
            ||..    ::.|:.::|:::...|.:::       ::|::|:|                :.:..|
 Frog   564 TLEPKADLNMSRKVNELQQILRQKEEDMRAMEDRYKRYVDKARTVIKSLDPKQQNCIPPEIQALK 628

  Fly   616 QKLYEIEARVSTYERENASLLKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQV 680
            .:|.|.:.|:...|.:     .|.:|::...|:|.:            ......:|.||
 Frog   629 NQLQEKDTRIRHLETD-----YEKTKVQRDHEEKLI------------ISAWYNMGMAL------ 670

  Fly   681 HQKLVELEKQNQELASQRIIDQEMIST 707
            |||..: |:......:|..:.|:.::|
 Frog   671 HQKATD-ERSQPPNGAQSFLAQQRLAT 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	39/160 (24%)
		SMC_prok_B	315..1110	CDD:274008	93/453 (21%)
hook2	XP_002938530.1	HkD_SF	8..157	CDD:425405	40/168 (24%)
		HOOK	180..702	CDD:461694	121/612 (20%)