DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and Mybpc2

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_038960733.1	Gene:	Mybpc2 / 292879	RGDID:	1311596	Length:	1153	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	113/383 - (29%)
Similarity:	162/383 - (42%)	Gaps:	59/383 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 EPGWRYQF-----RCFAENIVGRSDASELSDPLTVTLQRNAITVPRFIDELVDTNAVEDERIEFR 158
            |.|.|||.     :|.||.||.......|.|...:|::.:        ::.|....|.||::..:
  Rat   426 EDGGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKAS--------EQAVFKCEVSDEKVTGK 482

  Fly   159 VRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLVIHQVALTDEGEIKCTATNRAGHVITKA 223
                        |:|:|.|:..|:|..|.:......|||..|...|||:........|..:..|.
  Rat   483 ------------WYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKL 535

  Fly   224 RLM--------VQAPPKIRLP---RTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPG 277
            ..:        .|.||||.|.   :|.::.::|.|...|||.|.:.|:|||..|||...||....
  Rat   536 NFLEIKVEYVPKQEPPKIHLDCSGKTSDNSIVVVAGNKLRLDVAITGEPPPTATWLKGDEVFTVS 600

  Fly   278 -GRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTARPNPPGTPKLNMSFGK 341
             ||..:......|...|::..|.|.|.|.:|..|..|||..|..:.|...|:||...::. |.|:
  Rat   601 EGRTRIEQRPDCSSFVIESAERSDEGRYTIKVTNPAGEDVASIFLRVVDVPDPPEAVRVT-SVGE 664

  Fly   342 S-ATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKAATTRALSTTLHD--LIEGSEYKFRVKAEN 403
            . |.|.|..|..|||..:..|::|..:.|.:.|:|........||...  :|||..|:.||.|.|
  Rat   665 DWAILVWEPPKYDGGQPVTGYLMERKKKGSHRWMKLNFEVFTDTTYESTKMIEGVLYEMRVFAVN 729

  Fly   404 PYGLSEPSGESELLFIPDPKRGITKPKSATR--IAGDEKDKPKT---------GAGGM 450
            ..|:|:||..:: .|:|      ..|.||.:  ...|..|...|         ||||:
  Rat   730 AIGVSQPSMNTK-PFMP------IAPTSAPQHLTVEDVTDTTTTLKWRPPDRIGAGGI 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	12/32 (38%)
		I-set	138..227	CDD:254352	20/96 (21%)
		Ig	155..224	CDD:143165	16/68 (24%)
		IG_like	243..323	CDD:214653	29/80 (36%)
		Ig	250..323	CDD:299845	27/73 (37%)
		FN3	327..411	CDD:238020	29/86 (34%)
Mybpc2	XP_038960733.1	Ig	66..166	CDD:416386
		Ig strand A	67..70	CDD:409353
		Ig strand A'	73..76	CDD:409353
		Ig strand B	81..88	CDD:409353
		Ig strand C	97..102	CDD:409353
		Ig strand C'	107..109	CDD:409353
		Ig strand D	117..125	CDD:409353
		Ig strand E	132..136	CDD:409353
		Ig strand F	146..153	CDD:409353
		Ig strand G	157..166	CDD:409353
		THB	225..258	CDD:408162
		Ig	272..353	CDD:416386
		Ig strand A	272..274	CDD:409353
		Ig strand A'	277..281	CDD:409353
		Ig strand B	285..291	CDD:409353
		Ig strand C	298..303	CDD:409353
		Ig strand C'	306..309	CDD:409353
		Ig strand D	314..319	CDD:409353
		Ig strand E	322..327	CDD:409353
		Ig strand F	336..342	CDD:409353
		Ig strand G	345..353	CDD:409353
		Ig	360..446	CDD:416386	8/19 (42%)
		Ig strand B	374..380	CDD:409353
		Ig strand C	387..392	CDD:409353
		Ig strand C'	395..402	CDD:409353
		Ig strand D	407..412	CDD:409353
		Ig strand E	415..420	CDD:409353
		Ig strand F	429..435	CDD:409353	3/5 (60%)
		Ig strand G	438..446	CDD:409353	3/7 (43%)
		IG_like	459..>521	CDD:214653	19/81 (23%)
		Ig strand B	468..472	CDD:409353	1/3 (33%)
		Ig strand C	480..484	CDD:409353	0/15 (0%)
		Ig strand E	505..509	CDD:409353	1/3 (33%)
		Ig_C5_MyBP-C	562..647	CDD:409475	29/84 (35%)
		Ig strand B	574..578	CDD:409475	3/3 (100%)
		Ig strand C	587..591	CDD:409475	1/3 (33%)
		Ig strand E	613..617	CDD:409475	1/3 (33%)
		Ig strand F	627..632	CDD:409475	1/4 (25%)
		Ig strand G	640..643	CDD:409475	0/2 (0%)
		FN3	651..737	CDD:238020	29/86 (34%)
		FN3	750..842	CDD:238020	9/31 (29%)
		Ig_Titin_like	861..941	CDD:409406
		Ig strand B	870..874	CDD:409406
		Ig strand C	883..887	CDD:409406
		Ig strand E	907..911	CDD:409406
		Ig strand F	921..926	CDD:409406
		Ig strand G	934..937	CDD:409406
		FN3	946..1028	CDD:238020
		I-set	1060..1149	CDD:400151
		Ig strand A'	1068..1071	CDD:409353
		Ig strand B	1075..1084	CDD:409353
		Ig strand C	1089..1095	CDD:409353
		Ig strand C'	1098..1100	CDD:409353
		Ig strand D	1106..1110	CDD:409353
		Ig strand E	1113..1121	CDD:409353
		Ig strand F	1129..1136	CDD:409353
		Ig strand G	1139..1149	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X825
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000