DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BtbVII and CG12236

DIOPT Version :9

Sequence 1:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	155/534 - (29%)
Similarity:	231/534 - (43%)	Gaps:	110/534 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVQQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQ 66
            :.||:.|||||:..:......:...|...|||:|..:||:::|||:|||:|||||:.:|..||..
  Fly     3 TTQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHP 67

  Fly    67 HPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLA-------EMPTDPA-- 122
            ||::|.|.::::||.::::|||.|||||.||.|...|:|||:|.::||.       ::|..|.
  Fly    68 HPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEEKEKPQIPVAPLIS 132

  Fly   123 --NLTK---SDSKSSTDGTEMVGGAGVGTGAGN-----SAGSLGAGSGSSVGDSLWSSSEAQQFQ 177
              .|.|   |..::..:..:.|........|..     :|..|.|.:.|.|...:.:::.|....
  Fly   133 EHKLIKTIPSTIRAVNEQQQQVSNVAQAQTATQTIEIPAATLLQATNASQVPSQVVAAAAAAAAA 197

  Fly   178 QQQQQQAQQQAQQQHHHHQ---------------QQQQLQQQQQQAQQQQQQQQHHHHHHQQQQS 227
            ||.|.|.|   ||||||.|               ||||.||||||.||||||||      |||||
  Fly   198 QQLQVQHQ---QQQHHHVQTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQ------QQQQS 253

  Fly   228 GQAQA--AQTHHHQMRRTPSPLSAGTSPATRRKRLRKSSNNGSGDRNNAEEQHNSSLDAGSGAGN 290
            .|.|.  .||.|..:      .:|...||....:.||.:.:...|.....|..:.::....
  Fly   254 QQQQTTPVQTQHLTI------TNAVALPAASSVKKRKITFSDDDDNMYTTETVDYAVKDEQ---- 308

  Fly   291 AGLSLAQMNQMTF-----------------------GAGGGLAGHSLHAA-----------KLLK 321
               ::.:..:|||                       ||....:..:..||           ::|.
  Fly   309 ---TIVKTAEMTFLRGAVKMDIPDYIVGEVDDRLSDGATPQTSQDATTAAAQNVAQYSSEYEILT 370

  Fly   322 ESASAELEQQPQDSDLDDGHGHLHMQ--IKPEVDIGGVNQTMPLDISGG----TTPSEHDAPNSQ 380
            ||   |:|::.| :|.|:....:.|.  :.......|......::.|||    |.||...:....
  Fly   371 ES---EMEEKYQ-ADADNAEIAIEMTRLLGTASGTPGAGSGQVMEDSGGGSATTGPSTTVSVTQV 431

  Fly   381 SSHSEPSPAHAPHPPHPPLGAASSSSGG------SGSFERSFSIGGVGSVECDPDGTPSSPAVMG 439
            .|.|:.|..:|...|.....|.||.||.      :||.|.|....|:..:.|...|.|...  :.
  Fly   432 KSDSKASGTNAALKPGSVTVARSSKSGATASAPPAGSDEESVQYTGLAPLNCSFCGRPLKS--VN 494

  Fly   440 TKRNRVLTRQPRVK 453
            ..|..:.:|...::
  Fly   495 ALRRHIASRHSEIQ 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	45/99 (45%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	43/91 (47%)
CG12236	NP_727050.1	BTB	22..116	CDD:279045	44/93 (47%)
		BTB	33..116	CDD:197585	42/82 (51%)
		Herpes_capsid	<376..467	CDD:283714	21/91 (23%)
		C2H2 Zn finger	483..512	CDD:275371	5/28 (18%)
		C2H2 Zn finger	514..535	CDD:275371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020