DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg2 and GYS1

DIOPT Version :9

Sequence 1:	NP_647772.1	Gene:	Alg2 / 38374	FlyBaseID:	FBgn0035401	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_002094.2	Gene:	GYS1 / 2997	HGNCID:	4706	Length:	737	Species:	Homo sapiens

Alignment Length:	196	Identity:	37/196 - (18%)
Similarity:	62/196 - (31%)	Gaps:	48/196 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 RYERKKNHALALHSLRLLGDMLPATDFKRCRLIIAG----GYDTRCMEN------------VEHF 278
            ::.||...:|.:.||..:..||...||...:..|..    .:...|..|            :...
Human   399 KFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRI 463

  Fly   279 AELEHLTEELKLQDHVVLLRS-----PTDEEKCRLLFAAHCLLYTPENEHFGIVPLEGMYCSKPV 338
            .......:.:|:..|...|.|     |.|.|:  .:...|..::....|.:|..|.|......|.
Human   464 GLFNSSADRVKVIFHPEFLSSTSPLLPVDYEE--FVRGCHLGVFPSYYEPWGYTPAECTVMGIPS 526

  Fly   339 VALNSGG-----------PT--------------ETVVSTSTGFLCEKTEKSFGGAMLQLFRDEQ 378
            ::.|..|           |:              :...|..|.||....::|....::|..|.|:
Human   527 ISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTER 591

  Fly   379 L 379
            |
Human   592 L 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg2	NP_647772.1	RfaB	1..412	CDD:223515	37/196 (19%)
Alg2	NP_647772.1	GT1_ALG2_like	2..404	CDD:99977	37/196 (19%)
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:283373	37/196 (19%)
GYS1	NP_002094.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..737
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900