DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and Gk2

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001004077.1	Gene:	Gk2 / 289481	RGDID:	1303263	Length:	554	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	153/550 - (27%)
Similarity:	255/550 - (46%)	Gaps:	53/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AEESGPPDSPAFILALDVGTTCVRSFVLD-EQCEVRGSAVDAVELLN--PQPGYFEIEPESLWRK 82
            |:....|:.| .:.|:..||...|..|.: :..|:.||  ..|||..  |:.|:.|.:|:.:.:.
  Rat     2 ADSKETPEEP-LVGAVVQGTNSTRFLVFNPKTAELVGS--HQVELTQEYPKEGWVEEDPKEILQS 63

  Fly    83 IVGVIT---QAVKNAQLTPPDITCLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQWNA 144
            :...|.   :.:..|.:....|..:.:|.||.|.:.||..:||..:|.:.|.|||....|:..|.
  Rat    64 VYECIAKTCEKLTEANIDTSKIKAIGVSNQRETTVVWDKFTGEPLYNAVVWLDLRTQSTVESLNK 128

  Fly   145 SWTKSSMNWFSYALFLLTRQSRFLAGSV-LQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVELL 208
            .               :...|.|:.... |.|.......:|.:.:.|.:.:::|:.:.:|....:
  Rat   129 K---------------IPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNLRPIQKAVEEDRALFGTI 178

  Fly   209 DSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYKG 273
            |||::..:..|.:..   .|.||||:::.|.|::..:|.|...:...|.|...|||.|..:. :.
  Rat   179 DSWLIWCMTGGVNGG---IHCTDVTNASRTMLFNIHSLEWDKELCKFFEIPMSILPNVRSSS-EI 239

  Fly   274 FGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRCQAVIS 338
            :|.:...|.      ..:||:..|.||:||:.|..|||:...|.|.|||.||...||.:|.....
  Rat   240 YGQMTSGAL------EGVPISGCLGDQSAALVGQMCFQEGQAKNTYGTGCFLLCNTGQKCVFSEH 298

  Fly   339 GMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWAQ-SCELFDSPANTSDIAQSVPDTNDVFF 402
            |:...||::..|   .:.|.|.:||:....|.|:.|.: :.||..|.....|:|:.|......:|
  Rat   299 GLLTTVAYKLGK---NKPAFYALEGSVAIAGAVIRWLRDNFELITSSGEVEDLAREVGTAYGCYF 360

  Fly   403 MPAFSGLGPPVNDYRSASGFI-GLTPSTTKAHMVRALLESIVFRLVQLIEAAEKETSQKLHMIRV 466
            :||||||..|..: .||.|.| |||..|.|.|:..|.||::.|:..::::|..::....|..:||
  Rat   361 VPAFSGLYAPYWE-PSARGIICGLTQFTNKCHIAFAALEAVCFQTREIVDAMNRDCGIPLSHLRV 424

  Fly   467 DGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGI--W----RDVNDLKRFRKVA 525
            ||.::.|..:.|..||:..:.|.::...|::.:||...||...||  |    .|::.:...|
  Rat   425 DGRMTNNKILMQLQADILHIPVVKSVMPETTALGAAMAAGAAEGIDVWSIEPEDLSSMLMER--- 486

  Fly   526 RVFEPRPKEYETIANRMDKWSRTIARFSDW 555
              :||:.:..|: ..|...|.|.:.:...|
  Rat   487 --YEPQIQATES-EIRFSTWKRAVMKSMGW 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	149/537 (28%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	149/534 (28%)
Gk2	NP_001004077.1	glycerol_kin	11..513	CDD:273549	150/539 (28%)
Gk2	NP_001004077.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	150/539 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820